Tuesday, 15 Oct 2019

Gout/Crystal

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03 Oct 2019 Social Choi and colleagues have shown that allopurinol-associated severe cutaneous adverse reactions are higher with Heart (RR 1.44) and Renal (11 fold) disease. Initating low-dosage allopurinol may substantially mitigate this risk. https://t.co/gyj7Xn3uhx
01 Oct 2019 News Anakinra Use in Hospitalized Gout Patients
20 Sep 2019 News Higher Rates of Venous Thromboembolism in Gout
16 Sep 2019 Social Review of 24 guidance papers on gouts shows agreement over T2T fo ruric acid level and long-term controlindications for urate-lowering therapy 1st line drugs acute attack. Inconsistent were the initiation of ULT & Rx of asymptomatic hyperuricemia. https://t.co/j6v2Jp8L9t
11 Sep 2019 Social UK Clinical Practice Database compared 68,897 gout pts vs 554,964 without gout, showing gout doubles risk of (8.5/1000PY vs 4.1/1000PY w/o gout). Risk highest with ESRD. Gout did not increase CKD related deaths. https://t.co/oHpxa3ybVK
05 Sep 2019 News Modifiable Risk Factors for Hyperuricemia
20 Aug 2019 Social 87 #Gout patients treated with ULT and followed with serial Xrays and DECT scanning shows that lowering uric acid in a T2T strategy did not change xray over 2 years, but did show significantly less urate erosions by DECT. https://t.co/XRwkyyI4lr
14 Aug 2019 Social Cross sectional analysis of ~3000 and meta-analysis (14 studies) finds #gout has a higher risk of hypothyroidism, esp in female gout pts (OR=2.44;1.15-5.17); Metaanalysis ^risk hypothyroidism in gout (OR=1.51) and hyperuricemic pts (OR=1.34) https://t.co/1w3xfHqryJ
08 Aug 2019 Social Internet based study by Choi et al - looked at 517 gout patients and examined if gout flares were associated with vaccination. They found a twofold higher odds of gout flare (adjusted OR 1.99; 95% CI 1.01 to 3.89 in those who were vaccinated (any vaccine). https://t.co/8zLSt3YVZF
07 Aug 2019 Social Prospective study of 83 gout patients; 77 on urate lowering Rx, 6 discontinued Rx. The D/C group had no change in MSU deposits or SUA levels, In the ULT group MSU burden significantly decreased (MSU volume: p=0.007) and sUA dropped from 7.2 to 5,8 mg/dl. https://t.co/YfXjTKz1va
07 Aug 2019 Social PLoS reports that a study of 10,059 men from Israel were followed serially showing that higher variability in serum Uric Acid levels over 5 years was clearly predictive of 18-year Coronary heart disease and all-cause mortality. https://t.co/bDqI32aVXt
02 Aug 2019 Social 70 #gout pts studied & 44.3% developed post-surgical flares. Risk factors included Presurgical sUA ≥ 9 mg/dL (OR 3.77) & sUA changes before and after surgery (OR 1.62); but \allopurinol reduced risk (OR 0.15). Mean time to flare=3.7 days. Knee > MTP1 https://t.co/U6rl5c8Cf3
31 Jul 2019 Social Observational study of 124 gouty patients with high cholesterol & triglycerides treated with ULT (febuxostat, allopurinol, benzbromarone) showed that ULT significantly lowered SUA and lipid levels too. https://t.co/JSdh3TRTX3
31 Jul 2019 Social NHANES analysis shows that higher serum uric acid (SUA) levels had a greater risk of coronary heart disease and stroke mortality (mainly women >50 years); but there was no link between SUA and all-cause and cancer mortality. https://t.co/UGNSiKsjQl
26 Jul 2019 Social FDA has approved generic febuxostat 40 mg & 80 mg tabs, for gout - to be made by Read more at Business Medical Dialogues: Alembic Pharma gets USFDA nod for generic version of Uloric tablets https://t.co/QpnIoltFEP
21 Jul 2019 Social The RheumNow Podcast is up! Discussions on MDA-5 Abs & DM; gout & narcotics; IA capsaicin in OA; and ADA vs UPA. Watch here>> https://t.co/gZRJ2eHCqB or listen on iTunes or SoundCloud>> https://t.co/x6mCEqg6gU
19 Jul 2019 Social Mayo study comparing 429 Gout patients in 1990 and 2010 shows less 1st time Podagra 74% to 59% (p<0.001) and 24% higher flare rates in 2010. Predictors of future flares were hyperuricemia (HR 1.59) and CKD (HR 1.34) https://t.co/ZCgCzO7dUs
16 Jul 2019 Social ER study from 2015-17 shows that among 456 #gout patients, 28.3%) received opioid at discharge; 80% of these were new. Average dose was 38mg morphine equivalent for a median of 8 days - more likely w/ polyarticular gout, hx diabetes & hx prior opioids https://t.co/xf2jD1i4hg
08 Jul 2019 News Opioids Overused in Acute Gout
04 Jul 2019 Social RT @RheumNow: Comparison of high and low iris acid levels in a large cohort of gout patients shows high SUA associated with more comorbidit…