Tuesday, 17 Sep 2019

Gout/Crystal

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14 May 2018 Social UAB to lead the RECIPE trial in gout - a phase II trial to evaluate the utility of background mycophenolate (MMF) in patient receiving IV pegloticase injection for gout. Presumeably the MMF will block any interferring immunogenicity to PEG. https://t.co/ypBjwkeLpf
19 Jun 2018 Social Using medicare claims data, Singh & Cleveland show that elderly >65 yrs gout pts have a risk of MI = 4.1 per 1000 PYs and is 2 fold higher than those without gout. https://t.co/jozY7tc40r
07 Nov 2017 Social RT @philipcrobinson: Both generic and environmental factors influence the fractional excretion of uric acid #ACR17 @RheumNow #2061 https://…
16 Nov 2016 Social RT @rachelthuston: Mygoutcare - online educational resource for gout pts. #ACR16 @RheumNow https://t.co/OlxcEPQ2j4
16 Jun 2018 Social RT @DrPetryna: #eular18 @RheumNow ABST sat0357 only 51.7% of pts compliant with ULT ( allopurinol&uloric predominantly) after 1 year. The m…
20 Apr 2015 Social Allopurinol reviewed at RheumaKnowledgy http://buff.ly/1FZRNhc  via @Rheumnow
01 Dec 2016 Social @RonanTKavanagh @reinmd77 I start all new ULT (allopurinol, febuxostat) with either 5mg pred or NSAID (Never Colchicine). No flares IMHO
05 Mar 2019 Social An Internet survey of 320 physician-diagnosed #gout pts finds that 23% diagnosed as having a sleep disorder (sleep apnea, 17%). Their mean sleep time was 6.7 h per night; 86% reported snoring during sleep and 2/3 reported feeling sleepy during the day https://t.co/7DiuZOM1aw
08 Nov 2017 Social Pegloticase subanalyses show that IV Peg significantly lowers blood pressure, but only in the responders! (WATCH TH… https://t.co/dGBn6dNCcM
10 Oct 2018 Social CONTACT (Colchicine or Naproxen TX for Acute Gout) presented at the British Society of Rheum Mtg - 399 OL study finds equivalent responses betw Nap & Col, but trends favoring naproxen for lower early pain scores, side effects, less rescue pain meds https://t.co/MPgRNZo42b
23 Mar 2017 Social 3 US features of GOUT: double contour sign, tophus (hyperechoic aggregates), “snowstorm” of MSU aggregates https://t.co/ragnHxBTRW
27 Apr 2016 Social Erosive polyarthritis a RARE presentation of hydroxyapatite deposition Dz. More common is calcific periarthritis https://t.co/FosL2jRnN4
30 May 2017 Social British Soc.Rheumatology releases new guideline for Rx of gout; noting curative ULT must be offered to all pts early https://t.co/eda5E6V7Lp
17 May 2016 Social Gout prevalencein NIDDM is ~10%; Those w/ both likely to be elderly, men, obese, high lipids, neuropathy w/ Low GFR https://t.co/FWnneUXn11
13 Feb 2018 Social Systematic review of DECT Scanning in Gout included 32 articles & 1502 pts. DECT takes little time and has low radiation exposure but limited availability. It showed Sensitivity & Specificity > 80%. Dx performance was better than Xray, CT, equal to US https://t.co/GkbSKNP7D2
03 Jan 2019 Social Analysis of pegloticase clinical trial data shows that tophus resolution was achieved by 69.6% of 23 responders, 27.9% of 43 nonresponders, and 14.3% of 21 patients who received placebo. Resolution time = 9.9 mos. https://t.co/4Pu16t3BV8
02 Oct 2015 Social Cactus Registry of 3079 #Gout pts, more than 1/2 have obesity, HTN, Hi-Lipids. Mean entry urate = 8.7 mg/dl http://t.co/XVx11sqIG5
04 Nov 2017 Social RT @DrPetryna: FORTUNE1: stepwise ⬆️ of Uloric dose comparable to colchicine+Uloric in flare prevention during intro Rx https://t.co/MifSt…
16 Jul 2019 Social ER study from 2015-17 shows that among 456 #gout patients, 28.3%) received opioid at discharge; 80% of these were new. Average dose was 38mg morphine equivalent for a median of 8 days - more likely w/ polyarticular gout, hx diabetes & hx prior opioids https://t.co/xf2jD1i4hg
27 Jul 2016 Social Quercetin shown to signif. reduce Uric acid, it inhibits xanthine oxidoreductase in vitro. Not studied in gout. https://t.co/0Fq95UK3PS