Tuesday, 17 Sep 2019

Gout/Crystal

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13 Jun 2018 Social Dr Solomons plenary session on CANTOS substudy in @risk CVD pts shows Canakinumab lowered the risk of acute gout attacks by 50-60%, lowered hsCRP but not SUA levels. #EULAR2018 @RheumNow OP0014 https://t.co/7eWwHKDwrn
30 May 2017 Social British Soc.Rheumatology releases new guideline for Rx of gout; noting curative ULT must be offered to all pts early https://t.co/eda5E6V7Lp
17 May 2016 Social Gout prevalencein NIDDM is ~10%; Those w/ both likely to be elderly, men, obese, high lipids, neuropathy w/ Low GFR https://t.co/FWnneUXn11
13 Jul 2018 Social 5 year analysis of gout descriptors from 549 articles looked at 11 basic Dz elements & 343 unique labels, most being imprecise. An acute attack was represented by 162 unique labels w/ 1/3 articles referring to this element used at least four unique labels https://t.co/KrfhL1msu4
13 May 2015 Social NonAlcoholic fatty liver dz signif lower w/ regular low dose ASA; but higher w/ hyperuricemia http://t.co/8tS9dAkmuA http://t.co/Jod0578pcw
04 Nov 2017 Social RT @DrPetryna: FORTUNE1: stepwise ⬆️ of Uloric dose comparable to colchicine+Uloric in flare prevention during intro Rx https://t.co/MifSt…
16 Jul 2019 Social ER study from 2015-17 shows that among 456 #gout patients, 28.3%) received opioid at discharge; 80% of these were new. Average dose was 38mg morphine equivalent for a median of 8 days - more likely w/ polyarticular gout, hx diabetes & hx prior opioids https://t.co/xf2jD1i4hg
07 Dec 2017 Social Systematic review of ULT discontinuation - 5 studies shows that ULT D/C has good short term outcomes (esp if SUA is low) but delayed relapse rates occcuring 1-4.5 yrs later - more in gout (36-81%), less w/ urolithiasis (15%). https://t.co/RTIwuH154S
27 Jul 2016 Social Quercetin shown to signif. reduce Uric acid, it inhibits xanthine oxidoreductase in vitro. Not studied in gout. https://t.co/0Fq95UK3PS
06 Nov 2017 Social RT @KDAO2011: Gout pts more likely to achieve sUA goal< 6 mg/dL if managed by a rheumatologist. Go team Rheum! #ACR17 #166 @rheumnow https:…
07 Aug 2019 Social PLoS reports that a study of 10,059 men from Israel were followed serially showing that higher variability in serum Uric Acid levels over 5 years was clearly predictive of 18-year Coronary heart disease and all-cause mortality. https://t.co/bDqI32aVXt
28 Aug 2016 Social Gout patients have a 17% increased risk of fractures ( limbs & spine). Interestingly allopurinol use lowers risk https://t.co/aPKeAQTy0w
28 Sep 2018 Social Horizon announces a new trial to evaluate the efficacy of MTX in prolonging efficacy and preventing anti-PEG antibodies in refractory gout patients treated with Pegloticase IV https://t.co/x47QSzwdmO
12 Aug 2015 Social In CKD patients allopurinol adjustments may not be needed; but Colchicine must be adjusted w/ CKD- high toxicity risk http://t.co/ZsfwuCXxwv
07 Nov 2017 Social RT @psufka: Drink ☕️!!! Lower coffee consumption is associated with gout! #ACR17 @RheumNow #2066 https://t.co/oNCSZNbNlw
26 Apr 2018 Social A large CV prevention trial found 722 new gout cases among 12,866 men (age 35–57). Chronic kidney dz assoc w/ a 61% incr risk of gout (HR 1.61), increased w/ proteinuria & hematuria, but not by serum urate https://t.co/DOUBaACaM6
14 Mar 2017 Social Great review of Gout 2017 by Dr. Keenan. Gout care cost $31.8 billion from 2005-11 https://t.co/hq8zGLNzUw
21 Apr 2016 Social Gout on urate lowering Rx who get attacks are: 1) noncompliant; 2) not on right dose; 3) havent reached target <6; 4) new renal dysfunction
29 Jan 2019 Social QD Clinic - The Tophi Guy | Gout case management from https://t.co/2dcFVgu8z6 https://t.co/Nj3PbgVuFK
16 Jun 2018 Social RT @RonanTKavanagh: Vazquez-Mellado. Mexican patients with severe gout tend to be younger age at onset, lower educational level and socioec…