Monday, 26 Jun 2017

Gout/Crystal

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04 Feb 2016 Social Uricosuric effects are seen with Losartan, Irbesartan, CCB (amlodipine), fenofibrate, vitamin C, coffee, skim milk, yogurt and leflunomide
10 Jun 2015 Social Efficacy of Anakinra in Crystal synovitis. Complete improvement is seen in 3-5 days http://t.co/oTmnycx9m1
26 Apr 2016 Social Astra-Zeneca sells the rights to sell gout drug Zurampic (lesinurad) to Ironwood pharmaceutical for $265 million. https://t.co/GXht3lje3s
17 Aug 2015 Social Salivery uric acid levels measureable in gout - more proof that gout is a systemic uric acid deposition disease http://t.co/cA03VMuG39
01 Dec 2016 Social Takeda 2 yr study of 314 early #gout pts showed less acute flares w/ Uloric vs PBO (29% v 41%), but not in 1st 6mos. https://t.co/oTCYXyEX6o
11 Jun 2016 Social 1,280 gout compared to 1,231 OA pts; gout had more CVD risk factors, hypertension, ^lipids, CKD but not more MI. https://t.co/zP2SK3tfeM
15 Mar 2017 Social Xrays & DECT in 92 gout pts, tophi and urate assoc w/ 80% of all erosions. Urate, tophus volume predict erosions https://t.co/JlDle82bUx
04 Dec 2015 Social Prudent diet lowers risk of RA & gout, but a big Mac Western diet increases risk of RA & gout. Data from #ACR15 https://t.co/7fEFv9kyKE
09 May 2015 Social Review of Losartan shows its uricosuric, can lower Uric acid ~1.6 mg/dl & may be useful in HTN w/ hyperuricemia http://t.co/0zVqsvQIcO
16 Mar 2016 Social In a 6 mos RCT, Febuxostat slows the decline in GFR in CKD stages 3/4 compared to placebo. https://t.co/Au1mli9jAG
10 May 2016 Social Population (34K) based Taiwan study shows gout assoc w/ higher risk of depression; that is normalized w/ pred or ULT https://t.co/eRUJa4cLIr
02 Feb 2017 Social Risk of incident gout 70 fold higher w/ SUA >10; Risk of recurrent gout is 5 fold higher if SUA >9; https://t.co/GznuJ8tq1l
15 Jul 2016 Social Comic strips? Annals IM has one, Price of Progress", cost of colchicine , falls, CNS bleeds, hospitals. So pathetic https://t.co/HlEPDYYrkj
26 Oct 2015 Social 75 pts >50 yrs w knee effusions were studied:Ultrasound was more sensitive(60 v 40%) & specific (97 v 83%) than Xray https://t.co/dKr2BbZphN
16 May 2017 Social Drug induced hyperuricemia: Diuretics, EMB, PZA, ASA, CyA, fructose, nicotinic acid, Xylitol, lactate, cytotoxics https://t.co/CXdGxBJaMP
22 Sep 2016 Social #Gout & anti-HTN meds: diuretics, ꞵ-blockers, α-1 blockers signif increase uric acid levels. No effect w/ CCB, ACEI https://t.co/LnUTfz3zab
05 Jun 2015 Social Is Ultrasound changing Rheumatology practice? PMR & gout are examples of US changing the Dx & approach.http://t.co/JgTtQFuAOK
20 Apr 2016 Social NU-FLASH RCT 141 cardiac surgery pts w/ CKD+hyperuricemia Rx w/ Uloric vs Allopurinol. Uloric had lower SUA, CRP https://t.co/1Jt6u85tCv
03 Aug 2015 Social 81 arthritis pts (1/2 w/ gout) were studied w/ DECT scans. DECT had sensitivity of 90% and specificity of 83%. http://t.co/T3Izfk0WjU
03 Jun 2016 Social Astra-Zeneca has sold EU, L American marketing rights for Zurampic to Gruenenthal. In US sold to Ironwood. https://t.co/gKGEFXuwBq