Thursday, 20 Feb 2020

Gout/Crystal

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07 Aug 2019 Social Prospective study of 83 gout patients; 77 on urate lowering Rx, 6 discontinued Rx. The D/C group had no change in MSU deposits or SUA levels, In the ULT group MSU burden significantly decreased (MSU volume: p=0.007) and sUA dropped from 7.2 to 5,8 mg/dl. https://t.co/YfXjTKz1va
04 Mar 2018 Social RheumNow Wk in Review is up. Cool stuff on FDG PET in Lg Vessel vasculitis, gout Rx, nutraceuticals in OA. Listen here ht tps://buff.ly/2FhsZZH or watch it on website https://t.co/OZ1nGhCrSP
29 Nov 2019 Social New package labeling says febuxostat should only be considered after allopurinol has been tried or is contraindicated. https://t.co/Sk2MhEiOhv
06 Nov 2017 Social RT @KDAO2011: Risk for CV events lower in new start probenecid (rather than allopurinol) for older >65 yo pts #ACR17 @rheumnow #159 https:/…
13 May 2018 Social RT @GoutSolution: Immunosuppressive drugs ciclosporin and tacrolimus are also associated with #gout, especially the former combined with hy…
04 Feb 2016 Social Uricosuric effects are seen with Losartan, Irbesartan, CCB (amlodipine), fenofibrate, vitamin C, coffee, skim milk, yogurt and leflunomide
06 Feb 2020 Social Analysis of 30 synovial fluid samples (12 MSU, 18 CPPD); Gout crystals were ID at room temp (92%) & refrigerated (100%) for 7 days; CPPD crystals were less durable at room temperature (67%) after 7d; w/ less reduction when refrigerated in heparin tubes. https://t.co/H2zbjp1ONg
04 Dec 2015 Social Prudent diet lowers risk of RA & gout, but a big Mac Western diet increases risk of RA & gout. Data from #ACR15 https://t.co/7fEFv9kyKE
07 Nov 2017 Social RT @KDAO2011: Prior allopurinol use may reduce risk for NSAID induce acute kidney injury in gout pts #141 #ACR17 @rheumnow https://t.co/HTA…
16 Jun 2018 Social Abstract Sat 0356 showed pegloticase results in rapid resolution of tophus in bio chemical responders but is not influenced by age gender, race, BMI, tophus location. #EULAR https://t.co/rUWEHEA2fZ
13 Feb 2019 Social Genetic study using Mendelian randomization methods in a large UK biobank shows that whereas serum Uric acid has no association with eGFR level nor CKD risk, sUA does show a significant risk of #Gout. https://t.co/YRiVuOKof4
26 Apr 2016 Social Astra-Zeneca sells the rights to sell gout drug Zurampic (lesinurad) to Ironwood pharmaceutical for $265 million. https://t.co/GXht3lje3s
16 May 2019 Social Medicare analysis shows Gout patients are twice as likely to have chronic pain (HR 2.02; 95% CI 1.98-2.05) and use of allopurinol or febuxostat was associated with a lower risk of chronic pain (HR 0.72-0.79) https://t.co/xW5rVPyC69
01 Dec 2016 Social Takeda 2 yr study of 314 early #gout pts showed less acute flares w/ Uloric vs PBO (29% v 41%), but not in 1st 6mos. https://t.co/oTCYXyEX6o
08 Nov 2017 Social RT @WShergy: Low Uric acid may raise the risk of dementia. acr2017 @rheumnow#2080 https://t.co/bBL1mG0Ga7
11 Jun 2016 Social 1,280 gout compared to 1,231 OA pts; gout had more CVD risk factors, hypertension, ^lipids, CKD but not more MI. https://t.co/zP2SK3tfeM
10 Jun 2015 Social Efficacy of Anakinra in Crystal synovitis. Complete improvement is seen in 3-5 days http://t.co/oTmnycx9m1
15 Mar 2017 Social Xrays & DECT in 92 gout pts, tophi and urate assoc w/ 80% of all erosions. Urate, tophus volume predict erosions https://t.co/JlDle82bUx
07 Aug 2018 Social 10 yr study of ~13k US VA gout pts who did/didnt increase allopurinol shows dose escalation seldom achieved target SUA <6.0, but was associated with increased mortality (HR 1.08; 95%CI 1.01–1.17). Escalation more a marker of severity, not T2T https://t.co/NxzhnUfU2M
13 Nov 2019 Social RT @DrKanikaMonga: 2020 Gout Clinical Practice Guideline 42 recommendations (16 strong) - 27 ULT management (13 strong) - 5 Gout Flares (3…