Monday, 26 Aug 2019

RA/Inflammatory arthritis

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06 Aug 2019 News War on RA - Part 3: Useless Drugs
06 Aug 2019 Social Metanalysis of 9 studies shows that use of IVIG in ANCA-Associated vasculitis is assoc. w/ significant and rapid improvement in BVAS (SMD –1.7), ANCA (SMD –0.72) and CRP (SMD –0.92) within 2-24 weeks.
05 Aug 2019 Social War on RA - Parts 1 & 2 - Listen to the podcasts on iTunes or SoundCloud here: Part 1 - Walk on the Moon and Part 2 - All about You
05 Aug 2019 Social Claims analysis of 88,463 #RA pts (2006-2015) finds no greater risk of cardiovascular events w/ Tocilizumab (11.8/1000 PY) compared to TNF inhibitors (15/1000PY) or abatacept; suggesting no net increase in CVD w/ occ hyperlipidemia seen w/ TCZ
05 Aug 2019 Social Oral candidiasis (OC) is a significant predictor of severe infections during immunosuppressive Rx in ANCA-associated vasculitis. 71 pt cohort study; Predictors of severe infx: low albumin, pulse methylprednisolone (adj HR = 5.44), & OC (adjHR  5.31)
04 Aug 2019 Social 2nd Edition of my "The War on RA" - being fought daily by rheumatologists - Change, Innovation and Discovery will be driven by Rheumatologists. Rheums must lead the fight to win the immense challenge of #RA today. We need you!
02 Aug 2019 Social MMP-7 levels studied in myositis pts w/ anti-synthetase syndr (ARS) and fourd to be higher in ARS Ab+ & MDA5 Ab+ PM/DM-ILD patients, and were associated with a worse prognosis. MMP-7 levels associated w/ worse survival (OR 18.0).
02 Aug 2019 Social IL-18 may be a biomarker for Systemic JIA (Stills), higher w/ active dz and hx of MAS. Study of 40 sJIA pts finds elevated IL-18 levels inactive and active dz & with history of MAS. IL-18 was correlated w/ ferritin (R=0.74), CXCL9 (R=0.56), S100 (R=0.47)
01 Aug 2019 Social RA patients with an inadequate response to adalimumab, in the presence of sufficient/high ADA drug levels, benefit 33% less from switching to another TNF inhibitor, etanercept. Data 449 RA patients in the Reade Rheumatology Registry
31 Jul 2019 News Top Rheumatology Centers Led by Johns Hopkins
30 Jul 2019 Social The War on RA - is being fought daily by rheumatologists - Change, Innovation and Discovery will be driven by Rheumatologists if we are to win this war. This is the 2nd of a series on the immense challenge of #RA today. We need you!
30 Jul 2019 News War on RA - Part 2: It's All About You
29 Jul 2019 Social FDA will review to Genentechs application for Rituxan use in pediatric (age >2yrs) granulomatosis with polyangiitis & microscopic polyangiitis. If approved, this would be the 1st pediatric indication for RTX; data based on ths phase IIa PePRS study
28 Jul 2019 Social Im starting a War on RA. I need you go get mad and do your part. Read 1st of 4 part series or watch it here
26 Jul 2019 Social RT @drpnash: Effect of Filgotinib in Rheumatoid Arthritis Refractory to Disease-Modifying Antirheumatic Drugs - JAMA July 23/30 - Filgo (Ja…
25 Jul 2019 News Efficacy of Maintaining or Switching to Baricitinib Monotherapy
24 Jul 2019 Social Im starting a War on RA. I need you go get mad. Read it here or watch it here
23 Jul 2019 Social EUSTAR Study had 1451 systemic sclerosis (SSc) pts enrolled & 706 had complete data. Predictors of #SSc worsening included age, active digital ulcers, lung fibrosis, muscle weakness and elevated C-reactive protein level.
23 Jul 2019 News War on RA - Part 1: Walk on the Moon
22 Jul 2019 Social Weight loss does not reduce #RA risk. Swedish Obese (SOS) study followed 2002 bariatric surgery pts & 2034 controls. Overall 92 developed RA; RA risk now lower w/ bariatric surgery (HR 0.92; CI 0.59, 1.46) nor did wt loss; but CRP & smoking were