Friday, 15 Nov 2019

RA/Inflammatory arthritis

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21 Oct 2019 Social Retrospective study of 102 RA patients interstitial lung dz, and 52% had progressive fibrosing-ILD; these were associated with increased mortality. Predictors of mortality were DLco and high titres https://t.co/Ydd9xAhsag IgM rheumatoid factor
18 Oct 2019 Social Risk of uveitis in JIA - study 2294 JIA pts in the UK JIA registries finds that uveitis occured in 27/943 MTX, 16/1047, and only 1 of 304 adalimumab/infliximab Rx pts. No difference w/ MTX & etanercept, but much less with adalimumab https://t.co/rO13LznMmm
18 Oct 2019 Social RheumNow survey for Rheumatologists – When treating GCA, when do you add a steroid sparing agent? https://t.co/qhpOxYhsYV
18 Oct 2019 Social Study of RA complications from National Inpatient Sample data (2005-14) show #RA higher risk for MI (OR 1.03), COPD (1.67), CVA ( 2.2), renal Dz (1.42), EtOH abuse (2.73). Mortality trend increased significantly for CHF (P = 0.025) & AFib (P = 0.042) https://t.co/NzKPWsyKgA
17 Oct 2019 Social NEJM Case: 4-year-old girl with juvenile dermatomyositis refractory to multiple therapies has active rash, weakness & extensive calcification and strongly positive for anti–NXP-2 . Improved w/ infliximab, thalidomide, aluminum hydroxide. https://t.co/Wbb6JEMtrh
17 Oct 2019 Social UK population study of 6591incident RA patients shows comorbidity increased all-cause mortality (aHR 1.26; 1-1.6). Joint destruction had no effect, but COPD was associated with significantly more mortality (COPD HR 2.84; 1.13-7.12). https://t.co/6ULPvq34qh
16 Oct 2019 Social Evaluation of ANA testing in sytemic autoimmune dz (AID) finds low titers have low PPV. Highest PPV was for centromere pattern in PSS, w/ a PPV of 29% (1:160), 42% (1:32), 77% (1:640) & 82% (1:1280). Speckled PPV was low unti 1:1280 (PPV 71% for AID) https://t.co/JbDDXAOxOu
15 Oct 2019 Social RISE registry: among 7,274 RA pts w/ serial data [RAPID3 (78.9%) & CDAI (34.2%)]. Amongst those w/ moderate/high disease activity, frequency of DMARD change was low (36%-55%). Less likely to change was elderly, Combo DMARDs or biologics. https://t.co/IppHCxJWk1
14 Oct 2019 News Stress and the Risk of Incident Inflammatory Arthritis
13 Oct 2019 Social Study of 179 RA pts achieving remission on TCZ- SC 162 mg qwk randomized to continue qWk or space out to q2Wk -- Weekly Actemra better maintained remission (90% versus 73%; P = 0.004), but then again 73% did well w/ spacing to every other week. https://t.co/ywvsDMxS6M
12 Oct 2019 Social China retrospective study of 727 SoA abd 857 RA pts shows risk of H. Zoster same between SpA & RA (aHZ=0.97), but was significantly higher with MTX (adj HR 3.47) and infliximab (adj HR 10.67) https://t.co/gpictKPpIT
11 Oct 2019 News Juvenile Arthritis at Risk for Coronary Artery Disease
11 Oct 2019 Social FDA grants breakthrough status to OFEV (nintedanib) forthe treatment of chronic fibrosing interstitial lung diseases (ILDs), other than idiopathic pulmonary fibrosis (which it is currently approved for). Nintedanib has been studied in PSS ILD. https://t.co/K0ZTyqrfh6
10 Oct 2019 News Long Delays for Inflammatory Arthritis Patients
09 Oct 2019 Social What do you advise when RA pt complains of growing multiple RA nodules?
08 Oct 2019 Social 225 very early RA in abatacept AVERT study - 44% had high baseline MRI inflammation. With High MRI inflammation, combo ABA+MTX was better than MTX at 12 mos remission by SDAI (45% vs 16%). Pts w/ low baseline MRI inflammation, remission rates did the same https://t.co/A9MRSWaKGB
07 Oct 2019 Social Take the Good with the Bad? Study of 179 RA pts achieving remission on TCZ- SC 162 mg qwk randomized to continue qWk or space out to q2Wk -- Weekly Actemra better maintained remission (90% versus 73%; P = 0.004), but then again 73% did well w/ spacing EOW. https://t.co/Tcb2WwCbc2
07 Oct 2019 Social RT @ACRheum: Arthritis Care & Research Editors Pick: Impact of Patient's Global Assessment on Achieving Remission in Patients With Rheumato…
07 Oct 2019 News Antibiotics Increase Rheumatoid Risk - Again
04 Oct 2019 Social Get the FREE RheumaKnowledgy Card - a pocket guide/aid to the diagnosis, testing and Rx of Rheumatologic, autoimmune and other MSK complaints. https://t.co/oMa3qzh7xt