Friday, 18 Oct 2019

RA/Inflammatory arthritis

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27 Sep 2019 Social TIF1-γ antibodies may be associated with dermatomyositis and are found in between 13 – 31% of adults and 22 – 29% of children. TIF1-γ antibodies have a strong association with malignancy, esp in patients over the age of 39.
25 Sep 2019 Social 142 pts with ANCA-Associated Vasculitis were studied for lipid levels - Lipid levels increased during remission in newly diagnosed AAV and PR3+ AAV (not MPO or relapsing pts). Lipid levels correlated w/ ESR but not other inammatory markers.
25 Sep 2019 Social RT @RheumNow: Question for Rheumatologists - How do you scoreboard your performance as a Rheumatologist?
25 Sep 2019 Social 41 participants with RA and T2D were randomised to recv anakinra or a TNFi; RA dz activity decreased in both groups over 6 mos. Anakinra significantly improved A1C at 3 and 6 mos, but TNFi did not.
23 Sep 2019 Social Systemic sclerosis is associated with an increased cancer risk. A cohort of 1727 SSc pts showed an increased cancer SIR of 2.15 (CI 1.84‐2.49). Most common cancers were breast, melanoma, hematological & lung. CA risk higher w/ RNAP III Ab, CCB Rx & ILD
21 Sep 2019 Social The RheumNow Podcast is up – Should you Believe in Vitamin D or Rituximab? Watch it on RheumNow>> or listen to the podcast on iTunes or SoundCloud>>
20 Sep 2019 Social 29 Patients with MDA-5+ Dermatomyositis compliated by ILD were treated with high‐dose steroids, tacrolimus, and IV cyclophosphamide +/- Plasmapheres. 6 mos survival was better (89% and 33%, respectively, P < 0.0001) compared to 15 pts not treated
19 Sep 2019 Social S.Sweden study of ANCA Assoc Vasculitis (GPA, MPA, EGPA) 195 pts followed x8 yrs: found all cancers increased (SIR=2.8). SIR for squamous cell CA=12.9; 4.3 bladder cancer, & 7.0 for pancreatic CA. CYC total <10g were not associated w/ higher CA
18 Sep 2019 Social Rates of "indeterminate" results on quantiferon-IT assays were found to be significantly higher in systemic vasculitis (21%) than nonvasculitis pts and controls (7-7.5%). Indeterminate predictors were Syst vasculitis (OR 9.64), high NLR (OR 1.70).
18 Sep 2019 Social RT @HowardYangMD: Do your state have a pediatric rheumatologist? @ACRheum @ACRSimpleTasks #Act4Arthritis #rdam
12 Sep 2019 News Two vs. Four Weeks of Antibiotic Therapy in Septic Arthritis
12 Sep 2019 News Bimekizumab Add-on Therapy in Rheumatoid Arthritis
11 Sep 2019 News 74 Percent of Rheumatoid Arthritis Patients Dissatisfied with Treatment
11 Sep 2019 Social Based on a literature review, the prevalence of AA Amyloidosis in Adult onset Still's dz was 0.88%. 16 pt review showed mean age at AOSD onset was 30 yrs & a mean delay before AAA diagnosis of 16.75 yrs. Renal involvement was most common AAA feature.
09 Sep 2019 Social VA study of RA pts (2002-12) shows persistence on Rx at 1 year was 45% in for MTX- TNFi (n = 2,125) and 18% for triple therapy (MSH) (n = 171) (P < 0.001). Triple therapy group was associated with signicantly more treatment discontinuation (from SSZ)
06 Sep 2019 News RA Women are Less Likely to Breastfeed
06 Sep 2019 Slide of the day Carbamylated Abs and Risk of RA
05 Sep 2019 News Respiratory Risks Not Increased in RA Patients with COPD
05 Sep 2019 Social Cochrane review shows there are very few studies addressing whether smoking cessation leads to improvement in RA or inflammatory arthritis. 2 identified studies (57 pts only) failed to examine if smoking cessation intervention reduced disease activity
04 Sep 2019 Social A prospecitve cohort study of 278 axSpA pts, grouped them into alcohol drinkers and non-drinkers. Alcohol was associated w/ spinal progression (mSASSS changes ≥ 2 units overr 2 yrs) (60.7% vs 29.2%, P < 0.001, compared w/ nondrinkers). 1st time finding.