Friday, 15 Nov 2019

RA/Inflammatory arthritis

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04 Oct 2019 Social NEJM: Synovial Chondromatosis. A 46-year-old woman with rheumatoid arthritis presented with pain and swelling in both knees. Radiographic findings were consistent with synovial chondromatosis.
02 Oct 2019 Social MotherToBaby Pregnancy Study in 528 RA pts has shown oral steroid use yields a dose dependent risk of pre-term birth. PTB was increased high dose (RR: 4.77) and medium dose (aRR: 1.81) OCS in the 1st 139 gestational days; DMARDs/biologics were not
02 Oct 2019 Social Approximately 20–30% of IBD patients will develop spondyloarthritis. Using a survey tool on 244 IBD pts they found 21% with sufficient criteria to suspect SpA - Other risk factors included being female, Crohn's, prior DMARD or biologic drug use.
01 Oct 2019 Social RT @RheumNow: Survey for Rheumatologists - You would use an MRI in an RA to assess what?
01 Oct 2019 Social Retrospective claims study shows that higher ACPA and RF titers were independently associated with 60-78% increased mortality in established RA; the association persisted in when Rx with DMARDs, but not with biologics.
01 Oct 2019 Social Study of 101 RA pts w/ baseline Cardiac CT; after median of 83 mos, 48% had progression of plaque; predicted by older age, inflammation & prednisone (p<0.05). Coronary Art. Calcium progressors were older, obese, HTN w/ more inflammation
29 Sep 2019 Social Survey for Rheumatologists - You would use an MRI in an RA to assess what?
29 Sep 2019 Social RT @jeffsparks: 5-factor score for mortality in ANCA-associated vasculitis. I’ve never seen a worse Kaplan-Meier survival curve for those w…
27 Sep 2019 Social TIF1-γ antibodies may be associated with dermatomyositis and are found in between 13 – 31% of adults and 22 – 29% of children. TIF1-γ antibodies have a strong association with malignancy, esp in patients over the age of 39.
25 Sep 2019 Social 142 pts with ANCA-Associated Vasculitis were studied for lipid levels - Lipid levels increased during remission in newly diagnosed AAV and PR3+ AAV (not MPO or relapsing pts). Lipid levels correlated w/ ESR but not other inammatory markers.
25 Sep 2019 Social RT @RheumNow: Question for Rheumatologists - How do you scoreboard your performance as a Rheumatologist?
25 Sep 2019 Social 41 participants with RA and T2D were randomised to recv anakinra or a TNFi; RA dz activity decreased in both groups over 6 mos. Anakinra significantly improved A1C at 3 and 6 mos, but TNFi did not.
23 Sep 2019 Social Systemic sclerosis is associated with an increased cancer risk. A cohort of 1727 SSc pts showed an increased cancer SIR of 2.15 (CI 1.84‐2.49). Most common cancers were breast, melanoma, hematological & lung. CA risk higher w/ RNAP III Ab, CCB Rx & ILD
21 Sep 2019 Social The RheumNow Podcast is up – Should you Believe in Vitamin D or Rituximab? Watch it on RheumNow>> or listen to the podcast on iTunes or SoundCloud>>
20 Sep 2019 Social 29 Patients with MDA-5+ Dermatomyositis compliated by ILD were treated with high‐dose steroids, tacrolimus, and IV cyclophosphamide +/- Plasmapheres. 6 mos survival was better (89% and 33%, respectively, P < 0.0001) compared to 15 pts not treated
19 Sep 2019 Social S.Sweden study of ANCA Assoc Vasculitis (GPA, MPA, EGPA) 195 pts followed x8 yrs: found all cancers increased (SIR=2.8). SIR for squamous cell CA=12.9; 4.3 bladder cancer, & 7.0 for pancreatic CA. CYC total <10g were not associated w/ higher CA
18 Sep 2019 Social Rates of "indeterminate" results on quantiferon-IT assays were found to be significantly higher in systemic vasculitis (21%) than nonvasculitis pts and controls (7-7.5%). Indeterminate predictors were Syst vasculitis (OR 9.64), high NLR (OR 1.70).
18 Sep 2019 Social RT @HowardYangMD: Do your state have a pediatric rheumatologist? @ACRheum @ACRSimpleTasks #Act4Arthritis #rdam
12 Sep 2019 News Two vs. Four Weeks of Antibiotic Therapy in Septic Arthritis
12 Sep 2019 News Bimekizumab Add-on Therapy in Rheumatoid Arthritis