Tuesday, 20 Aug 2019

RA/Inflammatory arthritis

Datesort ascending Type Title Save
04 Jun 2019 News Might IL-17 Inhibition Be Effective in RA?
02 Jun 2019 Social Japanese study 198 systemic sclerosis pts finds higher skin thickness scores (modified Rodnan Skin Scores; mRSS) associated with higher risk of interstitial lung disease (P < 0.05), restrictive LDz(P < 0.01), and diffusion impairment (P < 0.05) https://t.co/PY4n6N5Ub9
30 May 2019 Social Japanese study 198 systemic sclerosis pts finds that higher skin thickness scores (modified Rodnan Skin Scores; mRSS) associated with higher risk of interstitial lung disease (P < 0.05), restrictive LDz(P < 0.01), and diffusion impairment (P < 0.05) https://t.co/PY4n6N5Ub9
24 May 2019 Social Study of hematuria in 86 ANCA Associated Vasculitis pts, compared half with & without hematuria after achieving remission from their glomerulonephritis. Hematuria at remission was not assoc w/ ESRD, but with relapse within 44 mos https://t.co/1ld4lOX1ih
22 May 2019 News Lung Disease in RA: Which Factors are Linked With Mortality?
20 May 2019 ACR Video RheumNow Live Preview with Dr. Michael Weinblatt (MTX: Who Would've Predicted Its Impact in RA?)
18 May 2019 Social 100 pts with oligoarticular inflam arthritis in India: Causes= periph SpA(n 37), axial SpA(11),TB (19), brucella (6), septic arthritis (6), gout (5), RA(5), NTMycobacteria (2), SLE (2), chikungunya (2), 1 Ea. w/ ALL, sarcoid, pachydermoperiostosis https://t.co/6fdxWnWENl
17 May 2019 News Opioids, SSRIs and Steroids Increase Fracture Risk in RA
16 May 2019 Social Discontinuing TNFi before wk 20 is feasible in RA and JIA pregnancy with well- controlled Dz. OTIS study of 490 women compared 25% who D/C TNFi before wk 20 vs 41% taking TNFi after wk 20. D/C TNF not assoc w/ clinical worsening in the 3rd trimester. https://t.co/J1qE3YZnHi
16 May 2019 Social Literature review - 23 studies on Natural dietary supplement (NDS) use finds that worldwide 47% of RA pts use NDS, did not differ by geographic region, 47% found NDS to be effective, 13% had adverse side effects, & 30% informed their physicians. https://t.co/N2O16NxuxU
15 May 2019 Social Reactivation of latent CMV infection is rare in Rheum Pts. 14 pts described w/ febrile illness, on steroids (13), with coinfections (8), 4 died during hospitalization, tend to have longer hospitalizations (47 vs. 7 days), more coinfections (67% vs. 17%) https://t.co/pijtFv55Uq
13 May 2019 Social Studies argue about MTX efficacy in GCA; many calling for new RCTs at higher doses. A new real world study compared 83 GCA pts on MTX (13.5mg/wk) vs 83 controls showing signif. lower relapse rates with MTX (0.32; 0.24–0.41), but no change in steroid use https://t.co/aCrL4PILUM
10 May 2019 Social The RheumNow Podcast is up! Watch it here https://t.co/fKvdmcuBtE or listen to the podcast on iTunes or SoundCloud https://t.co/IBOgZQvIiC
07 May 2019 Social Danish population study of 55,037 found 210 men (37.6% RF+) & 456 women (41% RF+) RA pts; In women, body fat%, waist size, & obesity was assoc. w/ higher risk of RA. (10% higher for each 5% body fat, 5% for each 5- cm in waist, & 50% higher for obese) https://t.co/PRUBWcWXjC
07 May 2019 Social Claims comparison of venous thromboembolic events (VTE) in treated RA pts finds a nonsignificant, but numerically higher rate of VTE in TOFA vs TNFi pts (0.60/100PY vs 0.34/100PY) (1.12/100PY vs 0.92/100PY), respectively. HR 1.33 (95% CI 0.78–2.24). https://t.co/JygSou07B1
07 May 2019 Social In first-degree relatives of RA patients, comparing ACPA pos and neg FDR finds all moderate to severe periodontitis was significantly more prevalent in ACPA+ FDR (91%) compared to ACPA neg FDR (40%). From the Journal of Clinical Periodontology https://t.co/5d4YKGszZO
06 May 2019 ACR Video RheumNow Live Preview with Dr. Philip Seo (Mimics of Vasculitis)
06 May 2019 Social Study of 281 Italian pts with temporal artery Bx-proven Giant cell arteritis shows increased mortality w/ large vessel involvement (HR 5.14) at diagnosis, and reduced mortality with PMR onset (HR 0.57) & adventitial inflammation (HR 0.31) on TABx. https://t.co/iF90cqYtqn
06 May 2019 News Denosumab Protects Against RA Erosions
03 May 2019 Social Analysis of new drug registration trials in RA (1998-2018) shows an increase in placebo responses (significant for ACR50 & ACR70); yet with significant reductions in Disease duration, SJCand DAS28-ESR. Changes in RA? RCTs? expectation bias? https://t.co/at6uesuNvL