Wednesday, 01 Apr 2020

RA/Inflammatory arthritis

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17 Jan 2020 Social 23% of RA patients have moderate-to-severe Obstructive Sleep Apnea (AHI ≥ 15) - study of RA patients 199 patients underwent PSG, OSA is more common in RA than in the general population, but there is no relationship with disease activity.
17 Jan 2020 Social Actress Tatum O'Neal, 56, was diagnosed with rheumatoid arthritis at age 50, but had symptoms for almost 10 years.
13 Jan 2020 Social 128 pts w/ Breast Cancer were evaluated for rheumatic complaints. Ultimately 1/3 developed an inflammatory rheumatic disease; most common being RA (8%), Sjogrens (6%) & PsA (5%). Arthralgias were more common with aromatase inhibitor use.
10 Jan 2020 Social UK study of 2701 Early arthritis pts Dx in 3 different eras finds that from those dx in 2010, 59% were estimated to reach low disease activity compared with 48% with diagnosis in 2002 and 32% with diagnosis in 1990.
09 Jan 2020 Social JAMA Case challenge: 61yoM with seronegative RA x yrs (rx w/ MTX and biologics) develops intermittent fever (38C), asymmetric polyarthralgias, & 50 lb Weight Loss, CRP 7.7mg/L. No response to TCZ and developed diarrhea. What do you do next?
09 Jan 2020 Social Dr. Heidi Jacobi #UTSW says limited SSc has slowly progressive skin thickening of the distal extremities but also the face and neck.
09 Jan 2020 Social Dr. Heidi Jacobi #UTSW says Raynauds, puffy digits and a +ANA should raise suspicion of systemic sclerosis. Also Carol tunnel syndrome may be a presenting feature
07 Jan 2020 Social CORRONA registry 880 RA pts developed a solid cancer. 42% taking bDMARD/tsDMARD; 5% switched biologics w/in 36 mos & 10% started a new biologic- w/ most changing to a TNFi (53%). ACR guidelines say to Rx regardless of solid tumor
07 Jan 2020 Social high-dose trivalent inactivated influenza vaccine (HD-TIV) was studied in 696 RA patients compared to standard-dose quadrivalent flu vaccine - Seroconversion was 3 fold higher w/ HD-TIV, no differences in side effects and no increase in RA flares
06 Jan 2020 Social Claims data from RA patients (n = 12,182), shows that screening for hyperlipidemia was suboptimal (compared to Diabetes pts), Those seeing a PCP and Rheum were 36% more likely to be screened.
06 Jan 2020 Social From the 9/11 World Trade Center registry, 118 persons found w/ a CTD (RA=71, Sjӧgrens 22, SLE 20, myositis 9,MCTD 7, PSS 4. Responders w/ intense dust cloud exposure had 2 fold CTD risk & Community members w/ PTSD had 3‐fold risk.
04 Jan 2020 Social 2019 YEAR IN REVIEW Podcast is up! Superheros, women, New Drugs, Novel Approaches, Failed drugs, MTX, Who's killing medicine & low dose pred Watch here>> or Podcast Listen on iTunes or Soundcloud >>
02 Jan 2020 Social Rates of "indeterminate" results on quantiferon-IT assays were found to be significantly higher in systemic vasculitis (21%) than nonvasculitis pts and controls (7-7.5%). Indeterminate predictors were Syst vasculitis (OR 9.64), high NLR (OR 1.70).
02 Jan 2020 Social anti-MDA5+ amyopathic dermatomyositis (ADM) with ILD is severe and refractory. NEJM letter reports on 18 ADM Rx w/ tofacitinibs who showed better 6 mo survival (100% vs 78%) (P=0.04) and improved ferritin, FVC, DLCO, & CT Chest over time.
02 Jan 2020 News Best of 2019 - War on RA - Part 1: Walk on the Moon
31 Dec 2019 Social Study of 182 hospitalized adult-onset Still's disease patients shows predictive factors for developing macrophage activation syndrome to include: 1. Splenomegaly (OR 5.7), 2. pericarditis (OR 6.5), and 3. ferritin >2000 (OR 4.7).
31 Dec 2019 News Best of 2019 - War on RA - Part 3: Useless Drugs
30 Dec 2019 Social Im starting a War on RA. I need you go get mad. Read it here or watch it here
27 Dec 2019 Social The Best Rheums go to the Best Meetings - RHEUMNOW LIVE - March 13-14-15 2020 Great Venue =Fort Worth. Short Lectures, interactive sessions, Q&A panels, TED (like) Talks, digital, streaming and much more. You dont want to miss this meeting!
27 Dec 2019 Social Study of 690 ambulatory patients examined RDW, ESR, CRP and showed RDW is increased in inflammatory disorders (RA, SpA) and elevated RDW has a 48–95% sensitivity and 66–95% specificity for inflammatory disease.