Monday, 26 Aug 2019

RA/Inflammatory arthritis

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10 Apr 2019 Social Long term tofacitinib in RA shows lymphocyte #s dropped ~24% by 48 mos. Monitor ALC at baseline & q3 mos; ALC <500 seen in 1.2% of 2983 pts and was assoc w/ higher risk of SIE & Zoster. ALC <500 more likely with low ALC, age, higher dose Tofa & MTX
09 Apr 2019 Social US Veterans Study examined 17,415 patients starting MTX - only 20.6% started a biologic w/in 2-yrs. Biologic use was significantly lower in elderly [aHR 0.20 ≥ 80 vs < 50], pts w/ comorbidities [aHR 0.79], CHF [0.68], cancer [0.78] & nonwhites [0.79]
08 Apr 2019 News Increasing Prevalence and Consequences of Interstitial Lung Disease in RA
08 Apr 2019 Social Analysis of CareRA, early RA 330 pt trial shows long term outcomes linked to initial response type rather than regimen. Best PROMs in the 42% with early persistent response. 9% were primary NR, 28% secondary NR, 21% delayed responders.
04 Apr 2019 Social RT @rheumarhyme: #RNL2019 But ANCA wont completely replace it. (depends on scenario) --Dr Langford
01 Apr 2019 News RheumNowLive On Demand: MTX Impact in RA - Dr. Michael Weinblatt
01 Apr 2019 News RheumNowLive On Demand: Pre-Clinical RA - Dr. Michael Holers
29 Mar 2019 Social 340 CCP+ persons without followed for 1047 PYrs = 21.5% developed RA. Risk of RA progression increased w/ CCP level. 46.0% of high level CCP patients progressedto RA by 5 years. High vs low CCP were 5 times more likely to get RA (HR 4.83, 95%CI 2.51-9.31).
28 Mar 2019 Social A cross-sectional study included 1276 RA outpatients showed the prevalence of dysfunctional LBP was 32.8%. Risk factors include BMI (OR 1.116; P < 0.001), onset age, disease duration of RA, MTX use, vertebral Fx, facet erosion, DAS-28CRP, pelvic tilt
28 Mar 2019 Social QD Clinic - Smoking & RA | RheumNow - Smoking ignites, worsens RA. How to stop smoking.
27 Mar 2019 ACR Video QD Clinic - Smoking & RA
25 Mar 2019 News Artificial Intelligence to Predict Rheumatoid Disease Activity
22 Mar 2019 Social Coal miners at higher risk for any arthritis (HR 2.3) and rheumatoid arthritis (HR 3.6)
21 Mar 2019 Social The risk of acute coronary syndromes in inflammatory myositis patients is doubled, especially in the first year (vs general population) and in older individuals. (HR 2.4; 1.8-3.2) - 7% IIM vs 3.3% in controls at 5 yrs.
20 Mar 2019 Social FREE Online viewing of RheumNow Live - Friday 3/22 at 1pm EST. 2 hr discussion blocks on RA, PsA, AS, SLE, Vasculitis. 10 "TED" talks interspersed from Cush, Calabrese, Van Vollenhoven, Schett, Matteson, Wolfe, Oransky,etc. SEE YOU THERE OR REGISTER HERE
16 Mar 2019 Social Daily noninvasive ultrasound (US) stimulation of the spleen significantly reduces disease severity in a murine model of inflammatory arthritis. Results mediated via T & B cell effects as T/B deficient mice did not improve with splenic US.
15 Mar 2019 ACR Video QD Clinic - The Power of Patient Choice
07 Mar 2019 News Multiple Delays in Referral of New RA Patients
07 Mar 2019 Social Claims analysis from Natl Taiwan Health Database, compared 262 JIA pts w/ controls & showed JIA pts have 30 fold higher risk of an adult autoimmune dz- Hazard Ratio=129.5 for RA; aHR-10.1 SLE, 49.62 AS & 8.2 PsA. Highest risk (46x) for JIA onset 11-15 yrs
07 Mar 2019 Social Rule of thumb on VTE risks: Normal population 0-.4/100PYs; RA patients are increased at 0.3-0.7/100 PY. If a new RA drug were to cause VTE (venous thromboembolic events; DVT/PE) it would have to have a rate consistently higher than 0.5 and probably higher than 0.7/100PY