Wednesday, 01 Apr 2020

RA/Inflammatory arthritis

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18 Dec 2019 Social Why are we guessing? A 20 yr #RA pt, Severe, erosive, polyarticular CCP+ RA, failed MTX, SSZ, Enbrel, Humira, Cimzia, Xeljanz, Orencia; had TJC 22, SJC 18, CDAI 37; put on LEF & IL-6 inhib & 2 mos later SJC 2, CDAI 3! HELP! We need a better way! AI #bigdata, #realbiomarkers
17 Dec 2019 Social retrospective cohort study of CCP+ individuals without RA, were followed, showing that they were more likely to progress to RA in 5 yrs if they had high CCP antibody levels (46%). (HR 4.83 [95% CI 2.51–9.31])
16 Dec 2019 Social Retrospective cohort study of 154 RA patients undergoing 244 major surgeries in shows that perioperative use of DMARDs (39%) or biologics (13%) was not associated with 30-day odds of post-operative infection #ACR19 Abst #1805
13 Dec 2019 Social Nurses Health Study - 284 incident #RA cases compared to 849 controls showing Asthma (not assoc w/ RA) but was strongly assoc w/ ACPA in blood prior to RA Dx (OR 3.6), independent of smoking. Chronic mucosal inflammation may lead to ACPA & RA
10 Dec 2019 Social 46 #RA pts on DMARDs +/- biologics received 3 part Hepatitis B Vaccination - those on biologics and DMARDs had less seroprotection vs controls (50% vs. 100% [p = 0.02] and 69.7% vs. 100% [p = 0.09], respectively). HBV vaccine well tolerated & without flare
09 Dec 2019 Social Serum Calprotectin levels were higher in the 157 RA pts who relapsed with DMARD withdrawal in the IMPROVED and RETRO Studies
09 Dec 2019 Social Achilles tendinitis Risk factors: 1) prior lower limb tendinopathy or Fx, 2) quinolones, 3) moderate alcohol, 4) cold weather training, 5) decr plantar flexor strength, 6) abnormal gait, 7) lateral foot roll-over 8) CrCl <60 in heart transplant pts.
09 Dec 2019 News Link Between Obstructive Lung Disease and Developing RA?
05 Dec 2019 Social Propensity Score–Matched Cohort claims study compared 11,248 matched pairs RA pts starting either abatacept or TNF inhibitor. ABA had a signficiantly lower risk of hospitalized infx compared to infliximab (HR 0.63), but equal SIE risk vs ETN or ADA.
04 Dec 2019 News Smoking Cessation Lowers RA Disease Activity and CV Risks
04 Dec 2019 Social Of 1757 systemic sclerosis patients in the EUSTAR study, 25% had diffuse SSc and 9% had current or previous digital gangrene, 16% had digital ulcers (DUs), not CV risk factors.
04 Dec 2019 Social Meta-analysis of 30 studies shows that ACPA-positive RA patients are marginally more likely to achieve EULAR and ACR20 responses with abatacept (RR 1.18; 95% CI 1.03, 1.35), but not with TNFα-i (RR 0.97; 0.86, 1.10) (compared to ACPA-negative)
02 Dec 2019 Social RT @philipcrobinson: If you needed more info that smoking isn’t great for #rheumatoid => Smoking cessation is associated with lower disease…
02 Dec 2019 Social ESPOIR cohort with 172 early seronegative #RA patients finds that early csDMARD use (within 3 mos of Sx) was more likely to predict better outcomes that other prognostic risk (clinical lab or imaging) factors
02 Dec 2019 Social Case-control study of 821 #RA cases & comorbidities between 2009 - 2018 shows some occur after RA- epilepsy (OR 2.13), sleep apnea (1.49), pulm fibrosis (4.63); others predispose to RA, IBD (3.82), T1DM (3.07), VTE (1.80)
02 Dec 2019 News Apremilast Reduces Oral Ulcers in Behcet's Syndrome
30 Nov 2019 Social RT @jeffsparks: Our new review article is online detailing airway inflammation and RA pathogens is - Obstructive lung diseases and risk of…
28 Nov 2019 Social RT @JohnDavisIII: Great piece by @jeffsparks and team on the role of airway inflammation and the pathogenesis of RA. #rheumatoidarthritis #…
28 Nov 2019 Social RT @psufka: Abstr# 1161: Gadolinium-enhanced MRI of the shoulders showing inflammatory changes in pts with PMR. Helpful to diagnose and det…
28 Nov 2019 Slide of the day Osteoarthritis vs. Rheumatoid Arthritis