Friday, 21 Sep 2018

RA/Inflammatory arthritis

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29 Apr 2018 Social RheumNow week in Review is up - FDA Showdown! Listen to the podcast on iTunes or here or watch the video
24 Apr 2018 News FDA Review: Take Two for Baricitinib
23 Apr 2018 Social FDA Arthritis advisory panel voting on baricitinib safety was 9-6 in favor of 2mg and was 11-4 against the safety of 4 mg
23 Apr 2018 Social FDA Arthritis panel on Baricitinib approval in RA votes 10-5 in favor of 2 mg dose but voted 10-5 Against baricitinib 4 mg dose. Concerns about safety of 4 mg dose, esp VTE, thrombophilia
23 Apr 2018 Social FDA Arthritis advisory panel voting in progress. Early votes unanimously in favor of baricitinib efficacy at 4 mg (15-0) or 2mg(14-1 unfavorably)
22 Apr 2018 Social RT @NatRevRheumatol: #TrendingNow Chester Oddis & Rohit Aggarwal discuss the treatment of myositis #myositis #treat…
20 Apr 2018 Social RT @RheumNow: RHEUMATOLOGIST VOTE: Active RA, SJC=5, fails 1st TNF inhibitor, which is your next choice:
20 Apr 2018 Social Fostamatinib, a spleen tyrosine kinase (Syk)inhibitor, that failed in #RA, has been FDA approved for use in adult with chronic immune thrombocytopenia (ITP) who have had an insufficient response to a previous treatment. The drug will be called Tavalisse.
19 Apr 2018 Social Study of 1181 Systemic Sclerosis pts finds 3.4% w/ hx of VTE events= VTE incidence of 2.7 per 1000 pt-yrs (equal to general population). Risk factors for VTE were PAH, peripheral arterial disease, Scl-70+, anticardiolipin Abs (OR 2.45-5.7)
19 Apr 2018 Social RHEUMATOLOGIST VOTE: Active RA, SJC=5, fails 1st TNF inhibitor, which is your next choice:
19 Apr 2018 News Shared Epitope - Smoking Pathogenic Link Clarified
17 Apr 2018 News Kineret Approved for Still's Disease in EU
16 Apr 2018 Social 2996 HIV+ patients on HRT finds 113 w/ Rheumatic disease, lead by AVN 39 (1.3%), psoriasis 28 (1%), RA 7, PsA 6, & SLE 6pts. HIV Males 1.7 times more likely to have a rheum Dz. Hep C incr the risk of RD. RD Risk in HIV+ appears same as gen population.
13 Apr 2018 News Mayo and UAB Awarded $1 million Grant for Patient Research
12 Apr 2018 Social In a historical prospective cohort study, PPI use in RA (1:4) was associated with a doubling of risk for acute kidney injury (HZ 2.30: 1.26-4.20) but was only 2.2 AKI per 1000PY in RA/PPI+ vs 0.9/1000PY in RA without PPI. Thus depends on need for PPI
09 Apr 2018 News Defining Refractory Rheumatoid Arthritis
09 Apr 2018 Social New RheumNow Survey on the risk of Venous-Thromboembolic Events in RA - Rheums vote here: (VTE is usually due to?)
09 Apr 2018 Social Abbvie announces results of its JAK inhibitor upadacitinib ouperforming adalimumab with ACR20 71%, ACR50 of 45%, 29 DAS remission, LDAS 45% at week 12
08 Apr 2018 Social 56 myositis patients with anti‐NXP‐2 autoantibodies (18 with and 38 without calcinosis) showed that NXP‐2 Ab levels correlate w/ disease activity, espcially in those without calcinosis; suggesting calcinosis defines 2 phenotypes.
06 Apr 2018 Social RheumNow Wk in Review is up! The Temporal Artery Biopsy Letdown! Listen or watch on the website