Wednesday, 20 Mar 2019

RA/Inflammatory arthritis

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24 Aug 2018 Social Study of 21 pts w/ cutaneous polyarteritis nodosa (PAN), 40% relapsed; Predictors of relapse included elevated CRP, ANC, neutrophil-to-lymphocyte ratios, and elevated systemic immune-inflammation indices.
23 Aug 2018 Social Comparative study of pregnant women with RA (n=657), JIA (170) vs 564 controls shows RA and JIA have 2 fold higher rates of pre-term delivery and risk of PTD was highest w/ RA activity and corticosteroid use.
23 Aug 2018 Social 1st Ceremonial Burial of Dead Words in Rheumatology - The Rheumatology Dead Word Cemetary (CTD, Rheumatism, CREST, MCTD, and more)
22 Aug 2018 Social Adult, Acute, Asymmetric Oligoarticular inflammatory arthritis - Whats your differential Dx? PsA, Spa, Reactive, IBD, Sarcoid, undifferentiated arthritis, CPPD, RA, chlamydia, Lyme ?
19 Aug 2018 Social Swedish Registry study of 2631 RA pts with Cancer - 20% received TNFi , rest did not. There was no increase in cancer recurrence on TNFi (HR 1.06; 95% CI, 0.73 to 1.54). Rheums should treat aggressively the arthritis and leave cancer to the oncologist
16 Aug 2018 News Early Exposure to Passive Smoke May Up Risk for RA Later in Life
15 Aug 2018 News Tumor Necrosis Factor Inhibitors Do Not Increase the Risk of Cancer Recurrence
13 Aug 2018 News Cardiovascular Benefits of Maintaining Biologic Therapy
12 Aug 2018 Social Dr. Gregg Silverman's monograph on RheumNow - have you read it? Do Autoantibodies Drive Disease in Seropositive RA? #sponsoredcontent
10 Aug 2018 Social DINORA study 90 Early RA pts Rx w/ PBO, MTX or MTX+infliximab, @1 yr Remission seen in 0, 14% & 32% respectively and in 2nd yr was maintained in 75% of the IFX + MTX compared to 20% of the MTX-only pts.
10 Aug 2018 Social RT @ARD_BMJ: Predictors of disease activity and structural progression after treatment with adalimumab plus methotrexate or continued metho…
08 Aug 2018 Social 204 Swedish Ank Spondylitis Men and women studied over 5 yrs. Men had more disease (mSASSS) and progression then women. Progression predicted by AS Xray findings and obesity; CRP was a risk factor for men; BASMI & bisphosphonates in women
08 Aug 2018 Social Microbiome study of 32 Behcet's vs 74 controls shows considerable gut microbiome changes, which is corroborated by a mouse study of fecal microbiota transplants.
07 Aug 2018 Social Neutrophil to lymphocyte ratio (NLR) ( in 160 pts w/ ANCA-associated vasculitis (AAV) was shown to correlate with BVAS activity. NLR ≥ 5.9 associated w/ severe disease, more relapses, but not death.
05 Aug 2018 Social RT @NatRevRheumatol: Bruce Cronstein discusses the interaction of Methotrexate and BAFF in the suppression of anti-drug antibody production…
05 Aug 2018 Social In Slovenia the #RA annual incidence 16.1/100,000 adults & the time from Sx onset to Rheumatology referral is 12.9 (4.4–26) wks; 36% were started on DMARD Tx within 12 wks of Sxs! I WISH THESE STATS WERE ACHIEVABLE IN USA !
04 Aug 2018 Social Population study from Slovenia and 704,342 adults shows the annual incidence rare of idiopathic inflammatory myopathies to be 11.5 per million females and 6.6 per million male adults
02 Aug 2018 News Maternal RA Increases Offspring Risk of Autoimmune Disorders
01 Aug 2018 Social ARTIC Study 222 early, DMARD naive RA patients, 53% achieved sustained DAS remission, 24% ACR/EULAR Boolean remission and 33% had sustained SDAI remission. Remission predicted by lower tender joint counts and short Dz duration.
30 Jul 2018 Social The latest issue of The Medical Letter is on "Drugs for Rheumatoid Arthritis" - detail/tables on DMARD and biologic use.