Wednesday, 21 Nov 2018

RA/Inflammatory arthritis

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08 Jun 2018 Social Olumiant will be 60% less than TNF inhibitors, and will carry a list price of around $25,000 a year.
07 Jun 2018 Social Although the mean age at death was higher in GCA than nl population, death in GCA is associated with aortic aneurysm/dissection (SMOR: 3.1), HTN (SMOR: 2.2), DM (1.96), Infection (1.76) & ischemic heart dz (1.45).
06 Jun 2018 Social RT @MattieRheumMD: Interesting to see how PBMs handle Lilly’s new Jak inhibitor,Olumiant priced @ 60% less than the top anti-Tnf. It is als…
06 Jun 2018 Social Metanalysis of 71 RCTs of biologics vs DMARDs in 23,535 RA patients failed to show a significant or meaninful effect of biologics (vs DMARDs) on mental health outcomes and that integrated mental health care may be necessary.
06 Jun 2018 Social Abbvie announced resultes of its SELECT EARLY study of MTX vs upadacitinib monotherapy in MTX-naïve RA pts. Wk 24 ACR 20 was MTX=59% and UPA 78-79%; ACR70 MTX=16% vs UPA=44-50%. UPA had less VTE than MTX.
05 Jun 2018 Social Quick review of the package insert details with the new RA drug baricitinib (Olumiant)
04 Jun 2018 Social Study of preclinical samples from 83 subsequent RA pts shows that double positivity (RF+ ACPA+) is associated with higher levels of proinflammatory cytokines and more rapid progression to develop #RA.
04 Jun 2018 News FDA Approves Low Dose Baricitinib for Rheumatoid Arthritis
03 Jun 2018 Social ⋆ TOP TWEET FDA approves Lilly's baricitinib (Olumiant) at the lower dose of 2 mg qd for adults with moderate-to-severe active rheumatoid arthritis who are refractory to TNF inhib. Mono or comb w/ DMARD. Boxed warnings for serious infections, Cancer, VTE
02 Jun 2018 Social RheumNow Wk in Review is up. Good news for GPA w/ Renal transplant, Early RA challenges, Vaccinots and HPV and the risk of cancer in PsA. Check out the podcast or the website video
01 Jun 2018 News FDA Approves Baricitinib 2 mg for Rheumatoid Arthritis
01 Jun 2018 Social German longitudinal study of 953 JIA pts shows that 3 years after Dx 75% achieve improvement and quality of life equal to their non-arthritic normal controls
31 May 2018 Slide of the day Swollen Hands In Rheumatoid Arthritis
31 May 2018 Social 43 yoM case of dermatomyositis-prox weakness, arthralgia, classic DM rashes. High CK, abnl EMG. Dx confirmed by skin & muscle Bx & +PM-Scl(75), MDA5 & SRP Abs; Despite mild weakness he died w/ progressive ILD, typical of MDA5.
30 May 2018 Social Retrospective study shows exposure to vapour, gas, dust and fumes (VGDF) increases risk of RF (not ACPA) positivity. Combined smoking and and VDGF exposure increases risk of RF and lower age of RA diagnosis than smokers with no VGDF exposure
30 May 2018 News Increased Risk of Depression and Anxiety in Rheumatoid Arthritis
30 May 2018 Social 5 Yr study of 403 early RA patients shows radiographic progression occurred in 143 (35.5%), more likely with high dose steroids and less likely with >36 mos of biologic therapy.
29 May 2018 Social In a DMARD naive, early RA cohort (U-Act) study, predictors of inadequate response to MTX included higher DAS28 (OR=2), current smoking (OR=3) and no alcohol consumption.
29 May 2018 Social British Biologics Registry of 19282 RA patients -the biologic SIE rate was 5.51 per 100 patient-yrs. The risk of death in the first 30days following a serious infection was 10%
26 May 2018 Social RT @ACRSimpleTasks: Beauty blogger Monica Sengupta is redefining fine art and beauty blogging. Steal her RA-friendly makeup secrets. Read m…