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12 Mar 2020 |
Social |
TNF inhibitors may slow, but do not stop, Xray progression in AS, Anti–IL-17A agents may maybe the same. Study by Inman et al shows that Tyk2 inhibition may prevent xray damage (animal model) by blocking IL-23 signaling and IL-22 production. https://t.co/OyyKoqdCl9 |
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11 Mar 2020 |
Social |
193 #RA pts starting a TNFi followed for 12ms; 21.7% were non‐adherent to TNFi - No difference between different TNFi's. Predictors of nonadherence included High age, low DZ activity, ^^comorbidities, more injection site pain & Rxns https://t.co/qclzJiglMj |
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25 Feb 2020 |
ACR Video |
QD Clinic - Latent Tuberculosis |
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17 Feb 2020 |
Social |
Slovenian National TB Registry (a non-endemic area w/ TB rate 6/100k similar to US). 2429 TNFi exposed (RA, AS, PsA)-6% required TB chemoprophylaxis; 6 RA and 2 PsA developed TB; 2 pts died. The TB incidence rate for TNF Rx pop was 45-51/100kPYs https://t.co/tam5I17QO1 |
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13 Feb 2020 |
Social |
RT @Janetbirdope: Do you prescribe TNFi for chronic idiopathic uveitis #RWCS2020 @RheumNow |
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04 Feb 2020 |
News |
Start with Anti-TNF in RA? Not So Fast |
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21 Jan 2020 |
Social |
A of TB risk with TNF inhib - Risks by country:
- Worldwide - 9.62 cases/1000 pts exposed
- Asia, 13.47 /1000
- S America 11.75 /1000
- Europe, 6.28 /1000 patients
- North America 4.34 /1000
(low risk (USA, EU) and high risk countries (Asia, S.Amer).
https://t.co/MNtnjbEuMS |
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21 Jan 2020 |
Social |
Anti-transcription intermediary factor 1 (TIF1)-γ autoantibodies are linked with cancer-associated Dermatomyositis in adults https://t.co/DeBoDdEbV1 |
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28 Dec 2019 |
Social |
Is the Serious infection (SIE) risk different between TCZ and TNFi? Not when used after failing 1 TNFi; But for biologic initiators, SIE risk was higher in TCZ compared to TNFi or ABA (based on claims data from 16074 TCZ matched to 33109 TNFi initiators https://t.co/ZHVWF9fIHF |
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27 Dec 2019 |
News |
Best of 2019 - The Shame Behind Adalimumab Biosimilars |
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09 Dec 2019 |
Slide of the day |
Even More Biosimilars |
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02 Dec 2019 |
Social |
Metanalysis shows that although MTX may blunt some vaccine responses (eg Pneumococcal), the use of MTX, TNF inhibitors and other biologics should not deter vaccination as most vaccine responses are preserved despite therapy. https://t.co/KINrQMIQkt |
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25 Nov 2019 |
Social |
VERVE results - Live zoster vaccine safe and effective in >600 patients with autoimmune diseases treated wth TNFi abstr#0824 #ACR19 @CCalabreseDO https://t.co/F8ipuG08O3 |
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13 Nov 2019 |
Social |
RT @hausmannMD: Holy Molly! TNFi (etanercept, adalimumab, infliximab, or golimumab) completely prevented stokes in patients with DADA2. #AC… |
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13 Nov 2019 |
Social |
RT @Janetbirdope: Infections In out patients are increased as measured by antimicromial scripts with RA and TNFi use comparing popn control… |
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13 Nov 2019 |
Social |
RT @DrKanikaMonga: - Risk of bDMARD withdrawal higher for TNFi monotherapy
compared w/ cs/bDMARD combination
- If monotherapy necessary, et… |
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10 Nov 2019 |
ACR Video |
Use of TNF Inhibitors: Dr. Olga Petryna |
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30 Oct 2019 |
News |
Psoriasis Risk Increased with TNF Inhibitors in Juveniles |
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28 Oct 2019 |
News |
The Shame Behind Adalimumab Biosimilars |
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28 Oct 2019 |
Slide of the day |
New Biosimilars for Rheumatology - 2019 |
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