Friday, 23 Mar 2018

TNF inhibitor

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18 Apr 2015 Social Listeria outbreaks recently. @risk Pts include infliximab, otherTNFi, MTX & Pred; rarely RTX or ABA, Mortality 11-27% 
04 May 2015 News DRESS Trial Shows TNFi Dose Reduction is Possible - Without Major Flares
14 May 2015 News Hepatotoxicity and TNF Inhibitors
14 May 2015 Social RheumNow: Major liver toxicity is rare with TNF inhibitors, minor LFTs are common.
17 May 2015 News Adalimumab Gets FDA Orphan Drug Status for Use in Hidradenitis Suppurativa
20 May 2015 Social TNFi Rx RA patients who also took MTX, had a significantly lower risk (64% less) for future large joint replacement.
22 May 2015 News Amgen & Abbvie Increase the Price of TNF Inhibitors
27 May 2015 News Nonadherence to Self-Injected Biologics is High
28 May 2015 Social Pt directed TNFi dose reduction in 58 Ank Spondylitis pts 94% effective @6 mos but only maintained in 54% over 2 yrs
05 Jun 2015 News Conventional DMARDs extend TNF inhibitor drug survival in patients with spondyloarthropathies
15 Jun 2015 Social #EULAR2015 OPTTIRA study: 97 LDAS RA pts (#SAT0150) tapered TNFi by 1/3 ->14% flares, 2/3-> 34% flares. 45% D/C TNFi
18 Jun 2015 News Frequency of Infliximab Infusion Reactions
23 Jun 2015 News Adherence to ETN/MTX is Greater Than Triple DMARD Therapy
29 Jun 2015 Social EU approves Simponi for Rx of adults with severe, non-radiographic axial spondyloarthritis, based on GO-AHEAD study.
30 Jun 2015 News Utility of Drug Levels and Anti-Drug Antibodies When Starting TNF inhibitors
01 Jul 2015 Social EMA recommends Humira for Rx of hydradenitis suppurativa based on >6000 pts. FDA granted orphan status in May 2015
05 Jul 2015 Social Hospira's Infectra biosimilar sold at 45% discount by a major French hospital group covering 1/4 of French population
05 Jul 2015 News Adalimumab Drug Levels Predict Efficacy
08 Jul 2015 Social TNF inhib use causes steatohepatitis? VA report 8 pts shows TNFi, MTX & PNPLA3 gene mutations may be risks for NAFLD
08 Jul 2015 News Neurologic Events with TNF Inhibitor Therapy