Thursday, 23 Jan 2020

TNF inhibitor

Date Typesort descending Title Save
03 Mar 2016 Social History of breast cancer pts can safely get TNF inhibitors without added risk of recurrence (from the TNFi) - data, guidelines support this
04 Nov 2017 Social RT @_connectedcare: I typically use this 2nd line for those not responding to TNFi in AS. What about you? #ACR17
10 May 2016 Social Cimzia successfully given to RA & SpA thru pregnancy w/ undetectable CMZ in cord blood;but 3/13 3rd trimester infxns
12 Feb 2018 Social RT @uptoTate: Obesity as a predictor for poor TNFi response in IBD. Dr. U. Mahadevan #RWCS @RheumNow
28 May 2015 Social Pt directed TNFi dose reduction in 58 Ank Spondylitis pts 94% effective @6 mos but only maintained in 54% over 2 yrs
15 Feb 2017 Social RT @DrRachelTate: Biosimilars - noninferior in switch trial from IFX and CT-P13 @RheumNow @RWCSmtg
04 Aug 2015 Social Animal model chronic inflammation: probiotics decrease TNF, improve socialization, but no effx on liver inflammation
09 May 2017 Social HUMOR Study - Humira shown to have no effect in hand OA. 43pt crossover RCT #OARSI mtg.
31 Mar 2016 Social Retrospective, comparative efficacy ADA,ETN,INF in 307 RA shows equal safety & efficacy; remissions 7.4/100PY/month
26 Oct 2016 Social Panel of neutrophil genes may be highly predictive of TNFi response in RA pts; CMPK2, IFIT1B, and RNASE3
24 Jan 2019 Social Using FMF-KI knockout mice (high TNF levels) researchers find TNF signaling drives pyrin & inflammasome activation; TNF is a critical modulator of pyrin of pyrin-inflammasomopathies like FMF. This is why TNF inhib sometimes work in inflammasomopathies.
01 Jul 2015 Social EMA recommends Humira for Rx of hydradenitis suppurativa based on >6000 pts. FDA granted orphan status in May 2015
10 Mar 2017 Social 2015 study of 4504 IBD pts shows TNFi use has 2 fold risk of central demyelinating Dz, w/ absolute risk 3.9/10000 PY
13 Nov 2019 Social RT @DrKanikaMonga: - Risk of bDMARD withdrawal higher for TNFi monotherapy compared w/ cs/bDMARD combination - If monotherapy necessary, et…
08 Nov 2015 Social RT @DrPetryna: #ACR15 #yearinreview TNFi tapering is more successful than complete TNFi withdrawal in established RA pts @RheumNow
01 Mar 2016 Social Prior hx of Cancer in IBD patients does not preclude the use of TNF inhibitors.
30 Apr 2016 Social Metanalysis: TNFi assoc w/ increase risk of perioperative infx (SSI): BUT risk decreases >38% w/ temporary cessation
26 Jan 2018 Social RheumNow Wk in Review is up. Discussing MPO bronchiectasis, $$ biologics, comorbidity in myositis, secondary TNF failure & ADAbs. Listen here Watch there
22 Jul 2015 Social Comparative biologic risk of TB Among 75000 pts: 31 TB due to TNFi, 1 w/ ABA; none w/ RTX, TCZ, Tofa, ustekinumab
28 Dec 2019 Social Is the Serious infection (SIE) risk different between TCZ and TNFi? Not when used after failing 1 TNFi; But for biologic initiators, SIE risk was higher in TCZ compared to TNFi or ABA (based on claims data from 16074 TCZ matched to 33109 TNFi initiators