Friday, 20 Oct 2017

TNF inhibitor

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21 Dec 2016 Social Janssen has filed for Simponi (golimumab) approvals for psoriatic athritis and anklylosing spondylitis https://t.co/dBv1o5WupX
05 Jul 2015 Social Hospira's Infectra biosimilar sold at 45% discount by a major French hospital group covering 1/4 of French population http://t.co/KSQoi6hG29
15 Mar 2017 Social 1241 PsA TNFi initiations - Persistence predictors include TNFi naive, more skin, prior DMARDs, Mod/High Dz activity https://t.co/WnFj6WtS33
09 Nov 2015 Social #ACR15 Abstract 550 (Buch etal) shows that TNFi related ANA positivity resolves w/ start of abatacept. (?due to d/c TNF or ?T cell affects)
15 Jun 2016 Social FDA Arthritis Advisory to review Amgens ABP501 (ADA biosimilar) on 7/12 & 7/13 review Sandoz GP2015 (biosimilar ETN) https://t.co/f9Bou7rsTH
03 Oct 2016 Social Mayo study of incident Sarcoidosis shows 3 fold higher risk of Venous thrombosis & 4 fold risk of pulm embolism. https://t.co/3Gv1bAumBf
18 Apr 2015 Social Listeria outbreaks recently. @risk Pts include infliximab, otherTNFi, MTX & Pred; rarely RTX or ABA, Mortality 11-27% http://buff.ly/1DVjSsR 
03 Feb 2017 Social infliximab 4 wks before TKA or THA did not increase risk of infection https://t.co/0PPLyNnNP5 @CCalabreseDO @HealioRheum @medpagetoday
25 Jul 2015 Social Metanalysis 40 RCTs & >10K TNF its show TB risk 0.26% (OR=25), higher in TNF+MTX (OR = 58) vs TNF mono therapy (OR=4) http://t.co/tqk1ArA7uc
09 May 2017 Social US Justice Dept is investigating J&J over management & advisory services to Rheum/GI regarding Simponi and Stelara. https://t.co/hKYacVYQaG
07 Dec 2015 Social RA on TNFi: 53% nonadherent, 20% markedly so. Nonadherence assoc w/ Low dz activity, comorbidity, age, MD-Pt discord https://t.co/ixsMCYad8R
30 Mar 2016 Social @RonanTKavanagh Fear of unknown is reason to ask for help (didnt happen). Stopping biologics will results in flare. Inflamm +XRT = bad news
26 Oct 2016 Social In Ireland, Pfizer has cut the price of Enbrel to match the price of Benepali - an ETN biosimilar. https://t.co/AKdp5bhHoc
09 Mar 2017 Social Analysis of FDA FAERS database shows TNF inhibitor ISRs are lower in pts >70yrs & lower when TNFi combined w/ MTX https://t.co/B4t6ivsQDG
22 Oct 2015 Social Goofiest report of the week: Blueberries augment etanercept effects in JIA - plausible but still goofy. https://t.co/OjsAsXpDWQ
18 Sep 2016 Social TNFi induced Psoriasis can be treated w/ TNFi D/C, another TNFi (48-85% recurrence) or Stelara. Good short review https://t.co/t2Hb7kA4ru
24 Jan 2017 Social Janssen has applied to FDA for new indications (AS, PsA) for golimumab based on GO-ALIVE, GO-VIBRANT trials https://t.co/qTZMJtWmya
14 Jul 2015 Social ESPGHAN cautions on biosimilar use; studies on safety & immunogenicity should be mandatory in children w/ IBD http://t.co/Gpa6HmP2U5
22 Apr 2017 Social FDA approves another infliximab biosimilar - Renflexis (Infliximab-abda) from Bioepis, distributed in US by Merck. https://t.co/r74qr73XaI
24 Mar 2016 Social 1st TNFi H2H results are in: EXXELERATE study Cimzia vs Humira shows equal ACR20 @3mo (69 v 71%) & LDAS @2y(35 v 33) https://t.co/qvcQdnAlxy