Tuesday, 07 Apr 2020

TNF inhibitor

Date Typesort ascending Title Save
31 Mar 2016 Social Retrospective, comparative efficacy ADA,ETN,INF in 307 RA shows equal safety & efficacy; remissions 7.4/100PY/month https://t.co/FgrQqQsB49
09 May 2017 Social HUMOR Study - Humira shown to have no effect in hand OA. 43pt crossover RCT #OARSI mtg. https://t.co/ZqBI1mGUN9
28 May 2015 Social Pt directed TNFi dose reduction in 58 Ank Spondylitis pts 94% effective @6 mos but only maintained in 54% over 2 yrs http://t.co/ALU5YezW6t
04 Aug 2015 Social Animal model chronic inflammation: probiotics decrease TNF, improve socialization, but no effx on liver inflammation http://t.co/gapL5A5TTM
26 Oct 2016 Social Panel of neutrophil genes may be highly predictive of TNFi response in RA pts; CMPK2, IFIT1B, and RNASE3 https://t.co/4jjaHdgGgQ
21 Jan 2020 Social A of TB risk with TNF inhib - Risks by country: - Worldwide - 9.62 cases/1000 pts exposed - Asia, 13.47 /1000 - S America 11.75 /1000 - Europe, 6.28 /1000 patients - North America 4.34 /1000 (low risk (USA, EU) and high risk countries (Asia, S.Amer). https://t.co/MNtnjbEuMS
15 Feb 2017 Social RT @DrRachelTate: Biosimilars - noninferior in switch trial from IFX and CT-P13 @RheumNow @RWCSmtg https://t.co/bBAaUWHGt1
30 Apr 2016 Social Metanalysis: TNFi assoc w/ increase risk of perioperative infx (SSI): BUT risk decreases >38% w/ temporary cessation https://t.co/PdZ1QLidvN
26 Jan 2018 Social RheumNow Wk in Review is up. Discussing MPO bronchiectasis, $$ biologics, comorbidity in myositis, secondary TNF failure & ADAbs. Listen here https://t.co/wmVyjrzOB1 Watch there https://t.co/32q2qojDZC
24 Jan 2019 Social Using FMF-KI knockout mice (high TNF levels) researchers find TNF signaling drives pyrin & inflammasome activation; TNF is a critical modulator of pyrin of pyrin-inflammasomopathies like FMF. This is why TNF inhib sometimes work in inflammasomopathies. https://t.co/0EvuTI57tn
01 Jul 2015 Social EMA recommends Humira for Rx of hydradenitis suppurativa based on >6000 pts. FDA granted orphan status in May 2015 http://t.co/WNn9ed3bXB
13 Nov 2019 Social RT @DrKanikaMonga: - Risk of bDMARD withdrawal higher for TNFi monotherapy compared w/ cs/bDMARD combination - If monotherapy necessary, et…
08 Nov 2015 Social RT @DrPetryna: #ACR15 #yearinreview TNFi tapering is more successful than complete TNFi withdrawal in established RA pts @RheumNow
01 Mar 2016 Social Prior hx of Cancer in IBD patients does not preclude the use of TNF inhibitors. https://t.co/D58N3Jj2cQ
10 Mar 2017 Social 2015 study of 4504 IBD pts shows TNFi use has 2 fold risk of central demyelinating Dz, w/ absolute risk 3.9/10000 PY https://t.co/v0MMvasUic
07 Nov 2017 Social RT @DrPetryna: #2453 #acr17 no difference in disease activity&PRO with ADA after MTX d/c at 6mo:LDA 42%ADAvs40%ADA+MTX @RheumNow https://t.…
22 Jul 2015 Social Comparative biologic risk of TB Among 75000 pts: 31 TB due to TNFi, 1 w/ ABA; none w/ RTX, TCZ, Tofa, ustekinumab http://t.co/cG8ranlUCN
24 Oct 2016 Social J&J will compete w/ price of Inflectra through a variety of innovative contracting options, discounts & rebates to payers, providers, & PBMs
28 Dec 2019 Social Is the Serious infection (SIE) risk different between TCZ and TNFi? Not when used after failing 1 TNFi; But for biologic initiators, SIE risk was higher in TCZ compared to TNFi or ABA (based on claims data from 16074 TCZ matched to 33109 TNFi initiators https://t.co/ZHVWF9fIHF
07 Dec 2015 Social Amgen filed its application for ABP-501 (Humira biosimilar) for approval w/ the EMA; includes Pso, RA, switch data https://t.co/Rfr6Z3XYQt