Friday, 15 Nov 2019

TNF inhibitor

Date Typesort ascending Title Save
23 Mar 2016 Social Real life H2H comparison 295 Humira & 84 Infliximab Rx Crohns showed non-significant equal failure rates (21 vs 25%)
02 Apr 2017 Social Abbvie announces that Humira is now FDA approved for use in severe finger nail psoriasis.
31 May 2016 Social Recurrent acute anterior uveitis responds to golimumab 50 mg qmo; 12/15 eyes from B27+ AS pts going into remission
06 Nov 2017 Social RT @japaoli19: Crib study shows no detectable levels of CZP on infants umbilical cords #ACR17 @RheumNow
09 Jul 2015 Social 1964 Turkish pts Rx w/ TNF inhibitors- TB rate of 466/100,000. TB risk greatest w/ Behcets; lower if PPD >10mm
18 Oct 2016 Social TNF inhibitor use in 16 renal transplant pts w/ good efficacy, no decline in GFR x2yrs, but 1/2 had Serious infxns
13 Feb 2016 Social FDA arthritis advisory votes 21-3 in favor of approving the Celltrion CT-P13 (Inflectra) a biosimilar of infliximab
03 Mar 2017 Social RT @USBiosimilars: #AAD2017 Surveyed physicians lack understanding of interchangeability. #Biosimilars Forum has info on this concept. http…
07 Apr 2016 Social Theres a new Biosimilar in the US called inflectra - some of the early talking points and issues covered @ RheumNow
12 Jan 2018 Social 188 PsA pts receive 1st TNFi, 27% D/C by 24 mos (1/3 for primary inefficacy, 22% secondary inefficacy, 43% adverse events) Predictors of failure = female or metabolic syndrome-co-morbidities (HR = 2.65).
30 Aug 2016 Social Drug retention rates are same between elderly and younger RA pts on TNFi. D/C for AE in old and efficacy in young.
21 Nov 2016 Social Retrosp study of Humira in 40 pts (66 eyes) w/ Behcets ocular dz showed signif less flares (200-->8.5/100PY) w/ ADA
21 Nov 2015 Social Do patients on TNF inhibitors become "born again"? well enough to go bungee jumping and join the marines!
24 Mar 2017 Social Amgens Amjevita (biosimilar of Humira) was approved by EMA for EU use in adult/Peds arthritis IBD, SpA & more
26 May 2016 Social TNF inhibitors & Traveling? 1 infusion or injection OK a Wk early or late 2 Forget the dry ice, keep syringe cool n dry (eg purse) on plane
04 Nov 2017 Social RT @psufka: @_connectedcare My approach: If primary nonresponse to TNFi -> IL-17. If secondary nonresponse to TNFi -> 2nd TNFi #ACR17
08 Jul 2015 Social TNF inhib use causes steatohepatitis? VA report 8 pts shows TNFi, MTX & PNPLA3 gene mutations may be risks for NAFLD
20 Feb 2018 Social PANTS study:Personalized anti-TNF Therapy in Crohn Disease tests real-world eficacy, safety & immunogenicity of infliximab vs biosimilar CT- P13 vs adalimumab. Wk 54 remission rate was 40% INFX, 40% CTP13 & 34% in ADA; immunogenicity was 26%, 28%, 11%
06 Oct 2016 Social IRAK3 rs11541076 polymorphism yields 33% increase odds of response to TNFi. NLRP3 rs461266 has 25% fewer responses.
17 Feb 2017 Social RT @DrRachelTate: Biosimilars - noninferior in switch trial from IFX and CT-P13 @RheumNow @RWCSmtg