Thursday, 20 Feb 2020

TNF inhibitor

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08 Mar 2017 Social Case and Review- Etanercept and other TNFi can be safely used to treat HIV positive patients.
28 Apr 2016 Social Metanalysis: TNFi assoc w/ increase risk of perioperative infx (SSI): BUT risk decreases >38% w/ temporary cessation
25 Oct 2018 Social RT @WIRheum: MTB screening in patients on TNFi When to re-screen? Neg to pos conversion discovered in a small number of cases Often in p…
29 Jun 2015 Social EU approves Simponi for Rx of adults with severe, non-radiographic axial spondyloarthritis, based on GO-AHEAD study.
16 Sep 2016 Social Humira price has increased 6% q 3month for 3 yrs - now $15 billion/yr in USA - what wil happen when biosimilars hi
06 Oct 2015 Social Enbrels patent (2029) being challenged by Sandoz's etanercept biosimilar recently filed w/ the FDA
23 Mar 2016 Social Real life H2H comparison 295 Humira & 84 Infliximab Rx Crohns showed non-significant equal failure rates (21 vs 25%)
02 Apr 2017 Social Abbvie announces that Humira is now FDA approved for use in severe finger nail psoriasis.
31 May 2016 Social Recurrent acute anterior uveitis responds to golimumab 50 mg qmo; 12/15 eyes from B27+ AS pts going into remission
09 Jul 2015 Social 1964 Turkish pts Rx w/ TNF inhibitors- TB rate of 466/100,000. TB risk greatest w/ Behcets; lower if PPD >10mm
18 Oct 2016 Social TNF inhibitor use in 16 renal transplant pts w/ good efficacy, no decline in GFR x2yrs, but 1/2 had Serious infxns
03 Dec 2015 Social In a placebo controlled RCT, 3 mg/kg infliximab injx fails to improve Sciatica from PostOp peridural lumbar fibrosis
12 Jan 2017 Social ARTIS #RA registry shows those initiating TNFi within 3 yrs of onset, double their odds of returning to work.
06 Nov 2017 Social RT @japaoli19: Crib study shows no detectable levels of CZP on infants umbilical cords #ACR17 @RheumNow
13 Feb 2016 Social FDA arthritis advisory votes 21-3 in favor of approving the Celltrion CT-P13 (Inflectra) a biosimilar of infliximab
03 Mar 2017 Social RT @USBiosimilars: #AAD2017 Surveyed physicians lack understanding of interchangeability. #Biosimilars Forum has info on this concept. http…
12 Jan 2018 Social 188 PsA pts receive 1st TNFi, 27% D/C by 24 mos (1/3 for primary inefficacy, 22% secondary inefficacy, 43% adverse events) Predictors of failure = female or metabolic syndrome-co-morbidities (HR = 2.65).
07 Apr 2016 Social Theres a new Biosimilar in the US called inflectra - some of the early talking points and issues covered @ RheumNow
30 Aug 2016 Social Drug retention rates are same between elderly and younger RA pts on TNFi. D/C for AE in old and efficacy in young.
17 Feb 2020 Social Slovenian National TB Registry (a non-endemic area w/ TB rate 6/100k similar to US). 2429 TNFi exposed (RA, AS, PsA)-6% required TB chemoprophylaxis; 6 RA and 2 PsA developed TB; 2 pts died. The TB incidence rate for TNF Rx pop was 45-51/100kPYs