Wednesday, 21 Aug 2019

TNF inhibitor

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09 Jul 2015 Social 1964 Turkish pts Rx w/ TNF inhibitors- TB rate of 466/100,000. TB risk greatest w/ Behcets; lower if PPD >10mm http://t.co/rWJIBKA3MO
14 Jul 2015 Social ESPGHAN cautions on biosimilar use; studies on safety & immunogenicity should be mandatory in children w/ IBD http://t.co/Gpa6HmP2U5
22 Jul 2015 Social Comparative biologic risk of TB Among 75000 pts: 31 TB due to TNFi, 1 w/ ABA; none w/ RTX, TCZ, Tofa, ustekinumab http://t.co/cG8ranlUCN
25 Jul 2015 Social Metanalysis 40 RCTs & >10K TNF its show TB risk 0.26% (OR=25), higher in TNF+MTX (OR = 58) vs TNF mono therapy (OR=4) http://t.co/tqk1ArA7uc
04 Aug 2015 Social Animal model chronic inflammation: probiotics decrease TNF, improve socialization, but no effx on liver inflammation http://t.co/gapL5A5TTM
06 Sep 2015 Social 2013 global sales: ETN $11.1 bill, INFL 9.9 bill, ADA 8.9 bill. RA sales increase from $56B in 2013 to $80B in 2020 http://t.co/2zWeVhP3XF
08 Sep 2015 Social An uncontrolled trial of ETN biosimilar ETANAR showed good safety & ACR20 90%, ACR50 86% & ACR70 65% at 12 mos http://t.co/rpl6ackVcx
14 Sep 2015 News Adalimumab FDA Approved for Hidradenitis Suppurativa
15 Sep 2015 Social Health Canada is reviewing few reports of schizophrenia & psychiatric dz associated with Enbrel use. http://t.co/pAFr2CSE1k
06 Oct 2015 Social Enbrels patent (2029) being challenged by Sandoz's etanercept biosimilar recently filed w/ the FDA http://t.co/73CDlh4l05
22 Oct 2015 Social Goofiest report of the week: Blueberries augment etanercept effects in JIA - plausible but still goofy. https://t.co/OjsAsXpDWQ
08 Nov 2015 Social RT @DrPetryna: #ACR15 #yearinreview TNFi tapering is more successful than complete TNFi withdrawal in established RA pts @RheumNow
09 Nov 2015 Social #ACR15 Abstract 550 (Buch etal) shows that TNFi related ANA positivity resolves w/ start of abatacept. (?due to d/c TNF or ?T cell affects)
16 Nov 2015 Blog The Born Again Rheumatoid
21 Nov 2015 Social Do patients on TNF inhibitors become "born again"? well enough to go bungee jumping and join the marines! https://t.co/e08St1MaIJ
30 Nov 2015 Social Amgen submits BLA application to the FDA for their version of adalimumab/HUMIRA (ABP 501) biosimilar https://t.co/KRjewSNeqf
03 Dec 2015 Social In a placebo controlled RCT, 3 mg/kg infliximab injx fails to improve Sciatica from PostOp peridural lumbar fibrosis https://t.co/4dnmhLOZ4F
04 Dec 2015 News In RA TNF-Inhibitors Prove To Be Durable Choice
07 Dec 2015 Social Amgen filed its application for ABP-501 (Humira biosimilar) for approval w/ the EMA; includes Pso, RA, switch data https://t.co/Rfr6Z3XYQt
07 Dec 2015 Social RA on TNFi: 53% nonadherent, 20% markedly so. Nonadherence assoc w/ Low dz activity, comorbidity, age, MD-Pt discord https://t.co/ixsMCYad8R