The MIRROR study, an open-label pilot trial in refractory, uncontrolled gout patients, showed that pegloticase given in combination with methotrexate was safe and effective and maintained responses for 6 months after initiation.Read Article
Dr. Rich Furie has lead a group of investIgators in reporting the significant efficacy of intravenous belimumab when added to standard of care induction therapy in patients with active lupus nephritis. This phase 3, 2-year study included 448 systemic lupus erythematosus patients with biopsy proven lupus nephritis (class III or IV +/- V) patients who required induction therapy and have a UPCR ≥1 g/g.Read Article
Data from the Framingham Heart Study has shown that hip fracture incidence has decreased over time, probably resulting from improved lifestyle changes (less smoking and heavy drinking).
The incidence of hip fracture has been shown to be decreasing in the US, presumeably attributeable to better osteoporosis treatment and care. This study examined the hip fracture incidence over the past 40 years in the US.Read Article
JAMA Internal Medicine reports on a controlled clinical trial of knee osteoarthritis patients wherein meloxicam responses were not significantly or clinically superior to placebo or CBT (after placebo).
Because of the uncertain benefits and safety of long-term NSAIDs, investigators sought to evaluate the comparative efficacy and safety of cognitive behavioral therapy (CBT) in knee osteoarthritis.Read Article