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Pirfenidone in RA-ILD, TRAIL-1 study. Long-awaited. Early termination due to COVID led to under-powering. Slowed decline in FVC, especially in UIP pattern. Seemed to have less adverse events than we see with nintedanib. Abstr#L10 #ACR21 @RheumNow https://t.co/sYRDhG3u4y
Richard Conway RichardPAConway ( View Tweet)
Artificial neural network showed good generalizability and a high specificity with acceptable sensitivity in the detection of radiographic sacroiliitis. A tool for interpretation of sacroiliac radiographs as a part of the diagnostic approach @RheumNow #ACR21 Abst#1919 #ACRbest https://t.co/SdmomEWwya
Dr. Antoni Chan synovialjoints ( View Tweet)
New dimensions in cellular immunology. Great session, some which I understood. Kids with #JIA have more cytolytic pathway missense - some leads to macrophage activation syndrome #MAS Low NK cells in Juvenile Dermatomyositis. 9T112 #ACR21 @RheumNow https://t.co/5lUkqr65UM
Janet Pope Janetbirdope ( View Tweet)
Adipokines in RA ⚡️Highest Quartile Adiponectin associated w/ ⬆️ all-cause mortality HR 1.46 ⬆️ CV mortality HR 1.85 ⚡️Highest Quartile Leptine ⬆️ 25% all-cause mortality #ACR21 #Abst1645 @RheumNow https://t.co/O1NAbfMvif https://t.co/VVdgZHP1j5

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Aurelie Najm AurelieRheumo ( View Tweet)
No clear excess risk for offspring exposed in-utero to, VED or TNFi's. UST showed infection signal BUT w/ wide CIs. We need more research re: biologics and placental transmission potential/subsequent risks. Abs 1713 #ACR21 #RheumNow #ACRbest @RheumNow https://t.co/W3K5uDyHlC

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Dr. Rachel Tate uptoTate ( View Tweet)

b/tsDMARDs + tumor response in rheum irAEs Excellent point by @CCalabreseDO @LCalabreseDO: - despite progression in 5/10, DMARD contribution uncertain (bad cancer) - without DMARD, ICI would have had to stop crucial question, prospective study needed #ACR21 ABST1519 @RheumNow https://t.co/omJnTNVscH
David Liew drdavidliew ( View Tweet)
The wave of the future? Study details immune profile which discriminates PsA from PsO using phenotyping of serum immune cell subsets & machine learning. Abs 1774 #ACR21 #RheumNow #ACRbest @RheumNow https://t.co/huNTY3IdRf https://t.co/3aW64pb9UW

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Dr. Rachel Tate uptoTate ( View Tweet)
Great case where the #COVIDvaccine was blamed, but he had a diet of doughnuts, steak&cheese sandwiches w/snack cakes, and popsicles. #ThievesMarket #ACR21 @rheumnow https://t.co/J78Nw5NhKs
TheDaoIndex KDAO2011 ( View Tweet)
The #ACR21 Playbook This playbook is designed to help you navigate a truly big meeting (with >2000 presentations and over 15,000 attendees from over 100+ countries). What follows is based on experience and the acquired insights our peers. https://t.co/GlDOnVfHsc https://t.co/RQlM2fjCzY

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Dr. John Cush RheumNow ( View Tweet)
Autoantibodies are underrated in rheumatic irAEs (?B cells in general), but probably not your usual. If Ab are of interest, suspect we're going to have to look at non-classical ones Elegant from @NilashaGhosh @MPostow @got_rheum @lovetolearn27 #ACR21 ABST1520 ABST1521 @RheumNow https://t.co/tLSJOZw1YG
David Liew drdavidliew ( View Tweet)
Great conversation with @BayviewMedicine @jhrheumatology alum Dr. Jason Liebowitz and Professor Janet Zeide on "Gift of Gab"- communications skills for the rheumatologist at #ACR21! @Rheumnow https://t.co/O1u3X8urag

Eric Dein ericdeinmd ( View Tweet)

Abst1783 #ACR21 #ACRBest @RheumNow Canadian study reports promising trends on hospitalizations for serious infections in PsA: 2012 – 2017 statist signif ⬇️ in discharges for sepsis, skin & soft tissue infect & UTI (p < 0.001 for all). no statistical difference in the trend of PNA https://t.co/lqtCzUFPAW
Olga Petryna DrPetryna ( View Tweet)
We may be getting a new urate lowering therapy. Tigulixostat is a non-purine selective xanthine oxidase inhibitor. Nothing worrying on safety. But I think febuxostat is probably more effective than this? Abstr#L05 #ACR21 @RheumNow https://t.co/Lg0slMlah2
Richard Conway RichardPAConway ( View Tweet)
Upadacitinib showed similar efficacy in AS pts compared to PsA pts with axial involvement ⭐️PsA pt w/ axial involvement and AS pts with differences in baseline characteristics #ACR21 @RheumNow Abs#1802 https://t.co/QvyayelBYU https://t.co/50dNQm30vf

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Robert B Chao, MD doctorRBC ( View Tweet)
How do RA pts go with ICI cancer therapy? @VUMCRheum audit reflects overall prev experience: - approx 50% flare (?some reflect DMARD W/H) - flares overwhelmingly managable - few (1/19 here) cease ICI due to RA flare RA pts deserve best cancer Rx too!! #ACR21 ABST1523 @RheumNow

David Liew drdavidliew ( View Tweet)

Advantages of treat to target (of serum urate) beyond less gout flares? Maybe equal to ⬇️MACE events - I hope in long term less MACE due to less ⬆️CRP w flares. Modelling observational study abst#L06 #ACR21 #ACRBest @RheumNow below is comparative safety T2T better than usual care https://t.co/95M6lNX416
Janet Pope Janetbirdope ( View Tweet)
Dr. Despotovic shares general principles about ICU admissions in patients w/ #rheumatic disease. 🔺#SLE, RA, systemic #vasculitis, SSc, IIMs 🔺serologic testing useful but interpret w/n clinical context @RheumNow #ACR21 https://t.co/jb3Mt31dZz
sheila RHEUMarampa ( View Tweet)
Abst1625 #ACR21 @RheumNow study of kids w/covid induced MIS-C: 91% w/shock & GI ax, conjunctivitis & mucocutaneous involvement. ⬆️CRP,D-Dimer, Troponin, &BNP. On ECHO, 36% had myocardial dysfunction &27% coronary artery abnormalities. 64% required ICU admiss. Rx IVIG& steroids

Olga Petryna DrPetryna ( View Tweet)

#ACR21 Thieves! TM11. Belly pain in patient with RA nodules: ⭐️ A: rheumatoid nodulosis of pancreas and duodenum. Great case! @Rheumnow https://t.co/PuO4tka3FJ
Eric Dein ericdeinmd ( View Tweet)
Excellent overview on assessment of patients with #PsA by @AlexisOgdie! Really clear and easy-to-follow slides to add structure to clinical assessment. #ACR21 @RheumNow https://t.co/XGZrCxOukm
Mrinalini Dey DrMiniDey ( View Tweet)
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