All News
#GreatDebate: add on BLMB vs. VCS to MMF for LN
Dr. Petri argues for BLMB b/c:
👉cost is less
👉better adherance
👉not good for class V
👉voclosporin had greater nephrotoxicity
👉insuff data in pregnancy, but not contraindicated like VSC #ACR21 @rheumnow https://t.co/mk2eXwkxcG
TheDaoIndex KDAO2011 ( View Tweet)
#ACR21 #GreatDebate: Dr. Rovin argues for VCS add to MMF b/c:
👉fewer side effects than legacy CNI
👉elevated in creatinine related hemodynamic reversible effect
👉did increase BP (but controllable)
@rheumnow (2/2) https://t.co/mmWp0sBveT
TheDaoIndex KDAO2011 ( View Tweet)
💻 Telemedicine: would you rather have a telephone or a video clinics? Non inferiority RCT shows 80% satisfaction rates and phone-only non-inferior to video visits. I would have expected patients to prefer video visits 🧐 #ACR21 #Abst0112
@RheumNow https://t.co/klgMJ6EthH https://t.co/17ffTAZCfv
Aurelie Najm AurelieRheumo ( View Tweet)
Data science for the dumbs. Very informative talk from Dr Jamie Collins! Surely helpful for me. A good way to decide on the best supervised methods for data analysis in machine learning is to separate according to our goal: to explain or to predict? #ACR2021 @RheumNow https://t.co/J0j6VMkoTV
Aurelie Najm AurelieRheumo ( View Tweet)
Don't forget to discuss Influenza vaccination w/ your RA patients! Higher concerns about RA medications and low necessity of vaccination beliefs associated with a ⬇️ likelihood of vaccination and suboptimal vaccine coverage.
#ACR21 @RheumNow #Abst0141 https://t.co/c5GthZxh3n https://t.co/4Nt92CHFzV
Aurelie Najm AurelieRheumo ( View Tweet)
Our Panel discussion on highlights of #ACR21 Day1 held live yesterday with great colleagues from @RheumNow faculty is now available online! 👯♀️ @RichardPAConway
@Yuz6Yusof @bella_metha @_Castillo_Pedro https://t.co/ulZTNNeqKf
Aurelie Najm AurelieRheumo ( View Tweet)
Abst#271 #ACR21. RA activity predicts left ventricular mass change in pts without CVD
⭐️35% had abnormal LV geometry at baseline TTE
⭐️55% at f/u TTE 3-6 years later
⭐️Increase in concentric remodeling on LV
@Rheumnow https://t.co/uHnqITcTy9 https://t.co/KmV8volVwd
Links:
Eric Dein ericdeinmd ( View Tweet)
#ACR21 Abst#0276:
Pulse pressure (PP) = Systolic BP - Diastolic BP, measures arterial compliance
⭐️RA: higher PP than controls
⭐️PP was independent risk factor for subclinical atherosclerosis
▶️ Look at the vitals, we have this at every pt visit!
@Rheumnow https://t.co/KZaf1AwO6Q https://t.co/kN4xGxWiV9
Links:
Eric Dein ericdeinmd ( View Tweet)
Before the Great Debate:
Next step for Lupus Nephritis?
#ACR21 @Rheumnow
Eric Dein ericdeinmd ( View Tweet)
#ACR21 Great Debate: Voclosporin vs Tacro?
⭐️Voclosporin has carbon bond extension, changing how voclosporin binds to calcineurin.
⭐️Consistent dose-response prevents need for drug monitoring
⭐️Increases potency and results in improved metabolic profile
@Rheumnow https://t.co/cY93st7754
Eric Dein ericdeinmd ( View Tweet)
Dr. Rovin at #ACR21 Great Debate:
▶️ Disagrees with Dr. Petri that GFR changes are caused by hemodynamics and is temporary, and non-nephrotoxic
▶️ Voclosporin + MMF is safe
@Rheumnow https://t.co/TxDyprnZ5u
Eric Dein ericdeinmd ( View Tweet)
Personalize decision points in belimumab vs voclosporin @jhrheumatology Dr. Petri
▶️ What is the outcome you are most interested in? GFR?
▶️ Is there extra-renal lupus
▶️ Infection risk
⭐️Ultimately, need biomarkers to know who will respond the best
@Rheumnow #ACR21 Great Debate
Eric Dein ericdeinmd ( View Tweet)
Enjoyed the @Rheumnow daily panel - #ACR21 day 3 is in the books!
https://t.co/Wp48PHRCHn
Eric Dein ericdeinmd ( View Tweet)
VEXAS plenary abst#1426 #ACR21 83 patients
🎙️vast majority mutations in p.MET41
Worse mortality when:-
▶️valine mutations on p.MET41
▶️ear chondritis
▶️being transfusion dependent https://t.co/qnA2lPn5yR
Bella Mehta bella_mehta ( View Tweet)
Pain in #spondyloarthritis is complex and multifactorial. Study of nearly 3000 patients, higher pain intensity was associated with working life impairment, spinal stiffness, education, gender, depression, anxiety and sleep @RheumNow, #ACR21 and Abst#0360 https://t.co/xEVI4L0Chw
Dr. Antoni Chan synovialjoints ( View Tweet)
There remains a need to increase knowledge and awareness of #axialspondyloarthritis in this US study of nearly 200 primary care physicians, less than half of the time were IBP symptoms, psoriasis, HLA-B27, CRP or MRI checked @RheumNow, #ACR21 Abst#0370
https://t.co/6Uyy45OEYZ
Dr. Antoni Chan synovialjoints ( View Tweet)
Abst0242 #ACR21 @RheumNow FROST: 1st line Rx of SJIA 73 pts. two study arms: biologics & GC/MTX arm. In biologic arm 14% IL-1i switched to IL-6i, 0% from IL-6i to IL-1i. 50%GC/MTX eventually initiated biologic therapy . 57% of pts d/cGC use, and 75% had cJADAS-10 score ≤ 2.5 https://t.co/vH0AnocTr2
Olga Petryna DrPetryna ( View Tweet)
Abst0357 #acr2021 @rheumnow Irish registry concludes higher level of unemployment in axSpA pts associated w/high disease activity, poor quality of life & worse spinal mobility https://t.co/GsGPLOoWsk
Olga Petryna DrPetryna ( View Tweet)
Abst0369 #acr2021 @rheumnow #acrbest ⬆️ level of pregnancy complications in axSpA in Irish registry. 41.9% complicated, 11.4% pregnan w/multiple complications. Miscarriage 20.5%. Amongst live births 10.8% c-section, preterm 11.4% . NICU admiss11.4%. ⬇️ breastfeeding rate at 33.7% https://t.co/plF8fykCKT
Olga Petryna DrPetryna ( View Tweet)
Abst0909 #ACR21 @RheumNow #acrbest real life study pinpoints higher disease burden, severity of depressed mood & higher Mean ASAS-HI in F pts w/AS. secukinumab improved disease activity, global functioning and severity of depressive mood in AS patients in both men and women https://t.co/fQycXY1aed
Olga Petryna DrPetryna ( View Tweet)