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Peripheral and axSpA pts with low Vitamin D levels (<30) had worse disease activity and functional impairment (BASDAI, ASDAS, BASFI) compared to pts with normal Vit D levels.
Abs#1316
#ACR21 @RheumNow
https://t.co/ulIqOAnWtp https://t.co/aMQaTpduJK
Robert B Chao, MD doctorRBC ( View Tweet)
@Sineadm15 @bososhea on undiagnosed depression in axSpA. Common, and associated with worse disease activity and quality of life. Abstr#1305 #ACR21 @RheumNow https://t.co/PBH1F3XEGv
Richard Conway RichardPAConway ( View Tweet)
#ACR21 Abs#1224. ⬇️ CD39 expression on B cell predicts occurrence of anti-drug Ab in RA on RTX
⭐️13/23 pts on RTX became ADAb+. No diff in concomitant MTX usage
⭐️Baseline CD73 similar, but lower CD39 predictive of ADAb
https://t.co/QzbAmXtTmZ @Rheumnow https://t.co/CLtEev69YD
Links:
Eric Dein ericdeinmd ( View Tweet)
Minimal disease activity achievement in PsA achieved by 22.8% in 6 mo of b/ts DMARD
MDA achievers were:
➡️Younger
➡️🔽 Disease duration;
➡️ Male
➡️Non-obese
➡️bDMARD-naïve at baseline
➡️🔼 probability achieving MDA components➕MCID PROMs at 6 mo
Abst# 1344 #ACR21 @Rheumnow
swethaann23 swethaann23 ( View Tweet)
Effect of BMI on PRO treatment response in PsA. Increasing BMI associated with lower response. More pronounced in TNFi than IL-17 or JAKi. Abstr#1327 #ACR21 @RheumNow https://t.co/qhgVlW72uM
Richard Conway RichardPAConway ( View Tweet)
In this study,
⭕AS pts w/>=2 #comorbidities were associated w/ poorer outcome measures after 2 yrs of ffup vs. pts w/ no comorbids
⭕Pts w/ >=2 comorbids were likely to dc 1st anti-TNF
Address comorbidities, ⬆ chances of better outcomes & QoL
@RheumNow #ACR21 abs1309 https://t.co/sTnjaC1a1l
sheila RHEUMarampa ( View Tweet)
#ACR21 Abs#1225: B/L Extracell Matrix Biomarkers predict ABA response in MTX-naive, +ACPA early RA
⭐️ECM biomarkers predict SDAI remission or DAS28 w ABA+MTX vs PBO+MTX.
⭐️⬆️CTX1 biomarker predicts efficacy endpts for ABA+MTX
https://t.co/7wHQefb5D4 @Rheumnow
Links:
Eric Dein ericdeinmd ( View Tweet)
Wk 12 disease activity predicts wk 24/26 remission/low disease activity with #upadacitinib 15mg in MTX-naïve or inadequate responders to MTX and/or TNFi pts.
≥50% improvement in SJC/TJC at Wk 12 was assoc with wk 24/26 remission/low disease activity.
Abs#1237 #ACR21 @RheumNow https://t.co/PAaCe5MAcu
Mrinalini Dey DrMiniDey ( View Tweet)
#ACR21 - Starting soon - The Gift of Gab! with @BayviewMedicine @jhrheumatology Jason Liebowitz moderating Communication for the Physician with @Wharton Janet Zeide. Learn about the RHEUM acronym for speaking! @Rheumnow https://t.co/wcgFUBcZeX
Eric Dein ericdeinmd ( View Tweet)
EULAR update on vaccines. HZ vaccine safe with csDMARDs and TNFα blockers. Reduced cell immune response after 1 year. Assess Varicella Abs if exposure unknown. Non-live recombinant subunit adjuvant zoster vaccine may be a game changer @RheumNow #ACR21 8M101 https://t.co/PTLqYGRIGf
Dr. Antoni Chan synovialjoints ( View Tweet)
Innovative!
Self-home fetal heart rate monitoring by the mother is feasible, accurate, effective for those with +anti-Ro/SSA Ab.
The study is still recruiting https://t.co/9BFihsgW5A Abst#1464 #ACR21 @rheumnow
https://t.co/ggmOpSGdZk
Links:
TheDaoIndex KDAO2011 ( View Tweet)
RheumNow’s expanded coverage of #ACR21 is sponsored in part by @Novartis. All content chosen by RheumNow & its Faculty.
Dr. John Cush RheumNow ( View Tweet)
Abs#1036: illness-related uncertainty significantly correlates with #depression, #anxiety, and sickness impact in patients with autoimmune #rheumaticdiseases.
Particularly strong associations with #AAV and #SSc.
#MentalHealth #ACR21 @RheumNow
https://t.co/SiV9fst3Bh https://t.co/w8VRQHdAJC
Mrinalini Dey DrMiniDey ( View Tweet)
⚡️A new biomarker of structural progression in RA? Plasma levels of CXCL13 ⬆️ @ baseline vs. ctrl and ⬇️ (p< 0.0001) after 1 yr treatment in a eRA cohort. Levels above 85pg/ml ⬆️ x5 risk of > severe radiographic status at 11yrs. @RheumNow #ACR21 #Abst1204 https://t.co/LnkayR1YrY https://t.co/W0xsgGuUDW
Aurelie Najm AurelieRheumo ( View Tweet)
#ACR21 Abst#1204. CXCL13 predicts long-term radiographic status in early RA
▶️ early RA has ⬆️ CXCL13, and ⬇️ w treatment
⭐️CXCL13 was best predictor of long-term radiographic destruction - better than DAS28CRP and CRP
@Rheumnow https://t.co/ydYRbKMBZ2 https://t.co/qinEFb86Az
Links:
Eric Dein ericdeinmd ( View Tweet)
Increased risk of vertebral fractures in PsA pts
OR 2.09 from meta-analysis and systematic review
Abs#1304
#ACR21
@RheumNow
https://t.co/0IazVBGHsF https://t.co/YrPMh1TZ6U
Robert B Chao, MD doctorRBC ( View Tweet)
#ACR21 Abst#1229: Does BMI influence efficacy of SC (fixed dose) vs IV (body-wt adjusted) ABA in RA?
⭐️No difference between SC and IV ABA by BMI
⭐️BMI impacts response to ABA as >2nd line therapy and retention, but no difference bw dosing
https://t.co/LqfZvLhBzU @Rheumnow
Links:
Eric Dein ericdeinmd ( View Tweet)
Is #calprotectin the new ESR/CRP?
👉🏼SLR finds calprotectin correlates w/ ultrasound synovitis in RA
👉🏼In some studies, it was a better biomarker than ESR/CRP
👉🏼It can distinguish ultrasound remission from subclinical synovitis
Abs#1207 #ACR21 @RheumNow
https://t.co/ADkRBq5KoG
Mrinalini Dey DrMiniDey ( View Tweet)
CATCH cohort: PT CDAI and MD CDAI correlate good to strongly at 3 and 6mo in patients with no non articular pain or w/regional pain but 🚨 NOT in pts w/ widespread pain! We should find alternative remote DA measures for this pop. #ACR21 @RheumNow #Abst1202 https://t.co/LsCtsfXsN1 https://t.co/gjeGxBA0HB
Links:
Aurelie Najm AurelieRheumo ( View Tweet)
My video summary on this important piece of work by @Sineadm15 is now available to watch on @RheumNow:
https://t.co/Gh64D4PADw
#ACR21 #MentalHealth #Depression #AxSpA https://t.co/EcH4VDs2Xi
Links:
Mrinalini Dey DrMiniDey ( View Tweet)