Are there people looking at steroid-sparing therapy as irAE treatment or prevention? @CCalabreseDO: are there ever #ACR21 irAE Study Group @RheumNow (also @NAbdelwahabMD @ReidMDMPH on stage) https://t.co/CLmNaLB68O

#ACR21 #Abstr1492 Could gut microbiome contribute to Anti-Ro+/autoimmunity in #lupus? Analyses of 125 stool samples from mother of children with neonatal lupus and/or heart block revealed its potential role in genetic-environment interaction @RheumNow https://t.co/FnJtZJSCRj https://t.co/ttRdP9NIrG

• A Permissive Factor of Anti-Ro+ Mothers of Neonatal Lupus Children Is Linked to…

#ACR21 Ab#1681: ATI-450- MK2 Inhibitor ⭐️Downstream MK2 mediated inflamm drive of p38. ⭐️Hope this would avoid tachyphylaxis in p38 inhibitor meds ▶️Phase2a study in 19 pts: Well-tolerated (SEs: UTI, ventricular extrasystole), good 12 week data @Rheumnow https://t.co/6lo7zPJUpx

• https://bit.ly/31M5LuT

Prof. Cornelia Weyand wonderfully summarizes the mechanisms behind the premature immune #aging phenotype in #RheumatoidArthritis leading to tissue #Inflammation 🔸defect in mitoDNA repair 🔸expanded rough ER 🔸⬇ protein myristoylation @RheumNow #ACR21 #RheumTwitter https://t.co/8cyqLscctB

Did you know?🤔Immune #aging: 🔖Begins at 20y and accelerates at 50y 🔖Species-specific 🔖The older immune system is restructured (keep that in mind when diagnosing or treating these pts) 🔖Accelerated w/ chemotx, chronic infection etc. @RheumNow #ACR21 https://t.co/bgbN3VKMCw

#ACR21 Year in Review. Caielli et al. showed in some patients with #lupus, red blood cells retained their mitochondria (Mito+ RBCs) and their frequency correlated with disease activity and blood⬆️IFN @RheumNow https://t.co/ZixgAbOWJ0 https://t.co/hkTWE4m7Ph

• DEFINE_ME

#Abstr0002 #ACR21 What drives salt in saliva in #sjogren? A study suggested Bcell cytokines mediated the epithelial Na+ Channel disruption. A case for targeting Bcell to improve oral health @RheumNow https://t.co/Bx3kBpOIFX https://t.co/YYnC6UoMJY

• Salivary Sodium Levels in the Parotid Salivary Gland of SS Patients Suggest B-c…

⭐️AxSpA pts with decrease in oral microbial diversity ⭐️Immune response to oral/fecal microbes altered in AxSpA pts. ⭐️HLA-B27 associated ⬆️IgA coated microbes, may contribute to development of AxSpA Abs#0052 https://t.co/NQgm0lpYJj #ACR21 @RheumNow

• https://bit.ly/3C2L4aB

Dr Preger report 9 novel aminoacyl tRNA synthetases in IIM patients. May these allow us to spare more patients biopsy? Abstr#0001 #ACR21 @RheumNow https://t.co/ikNXCEOeuj

apart from that, fibrosis is fascinating - as is the potential for a shared fibrotic pathway #ACR21 Antifibrotics session @RheumNow https://t.co/FXbhBx9sJ1