Skip to main content
      Recent Medscape Physician Compensation Report 2025, MD Salaries dropped by:
      Dermatology: -11%
      Neurology: -6%
      Urology: -6

      Dr. John Cush RheumNow

      3 weeks 2 days ago
      Recent Medscape Physician Compensation Report 2025, MD Salaries dropped by: Dermatology: -11% Neurology: -6% Urology: -6% Plastic surgery: -4% Cardiology: -4% Ophthalmology: -4% Gastroenterology: -3% Rheumatology: -3% https://t.co/kNKuBwbL8J https://t.co/fA7d5A3wJp
      Genetic sequencing as a research and diagnostic tool has expanded in medicine and rheumatology. An interesting review in Arthritis and Rheumatology suggests that despite currently modest use, there will be an expanded role for genetic sequencing in the field of rheumatology. 
      A national commercial claims analysis of first-line use of biologics in biologic−naive plaque psoriasis patients found a near doubling of net treatment costs from 2007 to 2021 ($21 236 to $47 125). Despite the increasing costs, the 2021 average cost could have been 44% lower if the lowest-cost drug in the same mechanistic class were chosen.
      Enzyme Porcupine inhibition of Wnt signaling is a promising treatment forsclerosteosis - rare Dz caused by SOST mutation

      Dr. John Cush RheumNow

      3 weeks 2 days ago
      Enzyme Porcupine inhibition of Wnt signaling is a promising treatment forsclerosteosis - rare Dz caused by SOST mutations & loss of functional sclerostin. Results in high bone mass & skeletal overgrowth (Sxs of facial paralysis, hearing loss, incr intracranial pressure https://t.co/9DYO82quiC
      JAMA Pt Education handout - Scleroderma https://t.co/UpK24WfyNF

      Dr. John Cush RheumNow

      3 weeks 3 days ago
      JAMA Pt Education handout - Scleroderma https://t.co/UpK24WfyNF
      Ultrasound lesions of dactylitis associ w/short-term development of PsA. Study of 64 PsO +arthralgia pts. IUS PD synovi

      Dr. John Cush RheumNow

      3 weeks 3 days ago
      Ultrasound lesions of dactylitis associ w/short-term development of PsA. Study of 64 PsO +arthralgia pts. IUS PD synovitis & B mode enthesitis predicted PsA Dx (p < .001) w/ an accuracy of 89.1 %, a sensitivity of 86.7 % and a specificity of 89.8 %. https://t.co/Ij6oYP1TuK https://t.co/55sO4uFXNI
      Phase 2, DBRPCT of nanobody anti-IL-17, izokibep in 172 Psoriatic arthritis pts, showed higher ACR50 rates for izokibep

      Dr. John Cush RheumNow

      3 weeks 3 days ago
      Phase 2, DBRPCT of nanobody anti-IL-17, izokibep in 172 Psoriatic arthritis pts, showed higher ACR50 rates for izokibep 80mg vs PBO at wk 16 (52% vs 13%; p=0.0006) w/ 40mg=48%. Other arthritis, psoriasis, enthesitis, dactylitis, QOL outcomes also improved.https://t.co/CQn9EVjr9g https://t.co/vVnTo2FPV6
      AutoAbs & protein signatures evolve as pts go from Preclinical to established RA. Pts vs controls distinguished w/in

      Dr. John Cush RheumNow

      3 weeks 3 days ago
      AutoAbs & protein signatures evolve as pts go from Preclinical to established RA. Pts vs controls distinguished w/in 5 yrs of Dx best by iCCP3, RFIgA, RFIgM; and 104 proteins differentially expressed & gene analyses showed 21 pathways enriched ≤5 years of Dx. https://t.co/u8abvqNtnX
      Daily purposeful walking assoc w/ lower risk of Knee OA (KOA). UK Biobank study of 89,969 persons, F/U 6.8 yrs - 2711 de

      Dr. John Cush RheumNow

      3 weeks 3 days ago
      Daily purposeful walking assoc w/ lower risk of Knee OA (KOA). UK Biobank study of 89,969 persons, F/U 6.8 yrs - 2711 developed KOA. HRs for incident KOA were 0.84 (0.76-0.92), 0.81 (0.71-0.90), and 0.74 (0.64-0.85) if walking ~5000, ~7000, & ≥8000 steps/d, respectively https://t.co/St9QLuOy9R
      Cardiovascular and Fracture Risk with Denosumab Versus Bisphosphonates in Dialysis Patients

      Annals of Internal Medicin

      Dr. John Cush RheumNow

      1 month 3 weeks ago
      Cardiovascular and Fracture Risk with Denosumab Versus Bisphosphonates in Dialysis Patients Annals of Internal Medicine has published a Japanese administrative claims database study showing that, compared with oral bisphosphonates (BIS), denosumab (DEN) lowered fracture risk… https://t.co/kNqGNTrsAF https://t.co/xgCeaMDT1N
      Increased Mortality In Arthritis Patients with COPD

      A new study published in the January 2025 issue of Chronic Obstruc

      Dr. John Cush RheumNow

      1 month 3 weeks ago
      Increased Mortality In Arthritis Patients with COPD A new study published in the January 2025 issue of Chronic Obstructive Pulmonary Diseases: Journal of the COPD Foundation, a peer-reviewed, open-access journal, finds that people with chronic obstructive pulmonary disease… https://t.co/6WCtfcrSaq https://t.co/ydVtBxqy37
      Congress Passes Fiscal Year 2025 Funding for Lupus Programs, including
      - $10 million Natl Lupus Patient Registry at CDC

      Dr. John Cush RheumNow

      1 month 3 weeks ago
      Congress Passes Fiscal Year 2025 Funding for Lupus Programs, including - $10 million Natl Lupus Patient Registry at CDC - $2 million Natl Lupus Training, Outreach, CTE Program - $47.08 billion for the National Institutes of Health SLE prgs https://t.co/BCs3lGdrXK https://t.co/58PkKG9ay6
      Japanese study of hip replacements (THA) - #RA pts undergoing THA at higher risk for dislocation and reoperation. Retros

      Dr. John Cush RheumNow

      1 month 3 weeks ago
      Japanese study of hip replacements (THA) - #RA pts undergoing THA at higher risk for dislocation and reoperation. Retrosp database study of THA - matching 3,951 RA vs 11,853 OA. w/ RA incr risk of dislocation (OR 2.8) & reoperation (OR: 2.25). No diff infx, Fx, VTE, death… https://t.co/Mz8niRlFaa https://t.co/mgcXTnw5Al
      Analysis of a Greek Psoriatic Arthritis (PsA) cohort shows that nearly one quarter of patients have axial involvement, and among them, ∼30% have isolated spinal axPsA and nr-axSpA, respectively.
      ×