More Rheumatology Fellow Advice from the Mentors
Aug 03, 2020
Recent News
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If you’re looking for some great advice to consider or rebuke, here is the generous guidance of nearly two dozen leaders in rheumatology who sincerely offer you their wisdom and best wishes.Read Article
Fighting Hydroxychloroquine Misinformation
Aug 03, 2020
JAMA Internal Medicine has posted an Editor's note on the use of hydroxychloroquine for COVID-19; noting the sequence of dysfunction since the president promoted its use on March 21, 2020, when he said “What do you have to lose? I’ll say it again: What do you have to lose? Take it.”.
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Retrospective study of 20 RA pts w/ resolved hepatitis B (HBcAb+; HBsAg neg). 16/20 were Rx w/ tocilizumab & 8/20 w/ tofacitinib (nearly all HBsAb+).
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Dr. John Cush @RheumNow ( View Tweet)
Aug 03, 2020
A large Latin American SLE cohort was studied; 66 (5.6%) had familial SLE & 1110 (94.4%) sporadic SLE: Familial SLE was more often associated with discoid LE (OR 1.97) & CNS dz (OR 1.65), more MSK Dz.
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Dr. John Cush @RheumNow ( View Tweet)
Aug 03, 2020
Systematic literature finds a connection between ankylosing spondylitis (AS) and dementia (RR 1.19 [95% CI 1.01‐1.41]). From a total of 6562 articles reviewed, only 4 met criteria - analysis included 156418 pts. Cause? inflammation, inactivity?
Dr. John Cush @RheumNow ( View Tweet)
Aug 03, 2020
The RheumNow Podcast is up - Top 13 Rheumatology Centers in the US; anakinra & colchicine in COVID, unload the loading dose, CB2 in Scleroderma.
Dr. John Cush @RheumNow ( View Tweet)
Aug 02, 2020
Uric Acid Targeting in Gout Management
Jul 31, 2020
A study from 2 gout clinics implementing different treatment strategies has shown that a treatment strategy that aims to strictly achieve low uric acid (UA) results in a higher a rate of targetd serum UA lowering and less gout flares.
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RheumNow Podcast - Top 13 Rheumatology Centers (7-31-20)
Jul 31, 2020
Dr. Jack Cush reviews the news and TOP 13 list of Best Rheumatology Hospitals.
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Spanish registry of 3679 SLE pts finds 13.6% had polyautoimmunity (SLE plus another autoimmune Dz), Dx as thyroiditis (8%), Sjogrens (14%) secondary APS (14%).
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Dr. John Cush @RheumNow ( View Tweet)
Jul 31, 2020
Based on a small number of studies (n = 5), there is little evidence to support the superiority (efficacy & safety) of Loading dose regimens when starting biologic (abatacept, certolizumab and secukinumab) therapy. https://t.co/0lNUzTFIOK
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Dr. John Cush @RheumNow ( View Tweet)
Jul 31, 2020
Sandoz rituximab biosimilar(SDZ-RTX; Rixathon) compared with reference rituximab (Ref-RTX) and shown to have same efficacy outcomes (DAS28 Remission, ACR20/50/70, CDAi/SDAI, HAQ), B cell depletion levels, adverse events & low level antidrug Abs https://t.co/0XWQ
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Dr. John Cush @RheumNow ( View Tweet)
Jul 31, 2020
Fracture risk & prevalence of osteoporosis is elevated in patients with idiopathic inflammatory myopathies: cross-sectional comparison of 52 myositis and 43 RA pts.
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Dr. John Cush @RheumNow ( View Tweet)
Jul 31, 2020
Colchicine Benefits COVID-19 Patients
Jul 30, 2020
A proof-of-concept study published in Annals of Rheumatic Disease suggests that colchicine significantly improves COVID-19 outcomes. Efficacy and safety must be determined in controlled clinical trials.he outbreak of COVID-19 posed the issue of urgently identifying treatment strategies. Colchicine was considered for this purpose based on well-recognised anti-inflammatory effects and potential antiviral properties.
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Safety & efficacy of rituximab in Older RA (>65; n=97) vs younger (<65yrs; n=276) showed no difference in drug survival over 2 yrs (72% vs 74%)or SDAI activity. BUT..
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Dr. John Cush @RheumNow ( View Tweet)
Jul 30, 2020
FDA recommends health care professionals discuss naloxone with all patients when prescribing opioid pain relievers or medicines to treat opioid use disorder.
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Dr. John Cush @RheumNow ( View Tweet)
Jul 30, 2020
Metanalysis of 10 studies ( p534 patients) shows that exercise in ankylosing spondylitis improves pain, function and disease activity. Statistically signif improvement in pain (P<0.0001), BASDAI (P <0.00001), and BASFI (P<0.00001), but not CRP and ESR.
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Dr. John Cush @RheumNow ( View Tweet)
Jul 30, 2020
Lenabasum (cannabinoid rcptr agonist) studied in Systemic Sclerosis - LEN (n=27) vs PBO (n=15).
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Dr. John Cush @RheumNow ( View Tweet)
Jul 29, 2020
The only thing worse than bad covid research is a meta-analysis of bad covid research
Vinay Prasad @VPrasadMDMPH ( View Tweet)
Jul 29, 2020
Important finding of marked lung fibrosis (scarring) after severe #COVID19 in 8 patients https://t.co/Akp6jVXmB9 @TheLancetInfDis
(first complete pathologic description of this finding) https://t.co/QCuri3olgs
Links:
Eric Topol @EricTopol ( View Tweet)
Jul 29, 2020
I have a rheumatology joke but it’s painful https://t.co/TUj1nY4JD4
Elizabeth Graef @SituationRheum ( View Tweet)
Jul 29, 2020
Platelet Rich Plasma Versus Hyaluronic Acid in the Treatment of Knee Osteoarthritis: a Meta-Analysis of 26 randomized controlled trials #osteoarthritis #knee #PRP #HA metanalysis favours PRP! https://t.co/Z5Olucs3ku
Peter Nash @drpnash ( View Tweet)
Jul 29, 2020
From the blog
Wisdom for New Rheumatology Fellows
Jul 30, 2020
Congratulations on choosing the greatest profession, one equally dedicated to both science and patient care. You are now part of a guild that will support you and anticipate your success. Rheumatology needs you to be a big thinking, futuristic problem-solving practitioner who will lead and learn, research and teach. Here are my words of wisdom for aspiring MSK phenoms.
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Recent Podcasts
RheumNow Podcast - Top 13 Rheumatology Centers (7-31-20)Jul 31, 2020-
RheumNow Podcast – COVID-19 Responds to Steroids (7.24.20)Jul 24, 2020
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RheumNow Podcast – LTF – Listen To Fauci (7.17.20)Jul 17, 2020
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RheumNow Podcast – Gout Guidelines (7.3.20)Jul 03, 2020
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RheumNow Podcast – Lupus Mortality Declines, But… (6.26.20)Jun 26, 2020
Therapeutic Update
Striving for Clinical Remission in Rheumatoid Arthritis
Sponsored By AbbVie Medical Affairs
Aug 01, 2020
How do you measure remission in your patients with RA? There are multiple composite measures that can be reliably utilized in clinical practice to assess disease activity and remission. This article highlights these measures and how treatment with upadacitinib, with or without MTX, was assessed across multiple measures of remission in the SELECT program.
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