Current ACR guidelines for the management of gout support anti-inflammatory prophylaxis, including colchicine, during urate lowering therapy initiation and uptitration. Aside from diarrhea, colchicine use is generally well tolerated, but its metabolism via the CYP3A4 cytochrome P450 enzyme pathway poses a potential risk of medication interaction. Statins are one of the most widely prescribed medication classes also metabolized by this pathway
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Read ArticleHallux rigidus, or osteoarthritis of the first metatarsophalangeal joint (MTPJ), is common, but the treatment options and future outcomes are poorly known.
Avacopan (Tavneos), the complement pathway inhibitor for antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), appeared strongly effective in an Italian registry study -- a step, maybe, toward setting to rest questions about its efficacy, if not its safety.
After years of inactivity, therapeutic development for dermatomyositis has begun to move forward with several new therapies and therapeutic strategies.

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