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Today is the PDUFA date wherein the FDA decides the fate of Aurinias calcineurin inhibitor, Voclosporin, use in lupus nephritis. https://t.co/6du61xGrDq https://t.co/2knPWyNmu4
Dr. John Cush @RheumNow (  View Tweet)
Jan 22, 2021
COVID Vaccine Q & A - Dr Kevin Winthrop Dr. Cush interviews Dr.
Dr. John Cush @RheumNow (  View Tweet)
Jan 22, 2021
MMWR reports 10 cases of anaphylaxis after 4 million doses of Moderna COVID-19 vaccine (2.5 cases per million doses administered). 9/10 occurred within 15 minutes of vaccination. No anaphylaxis-related deaths were reported. https://t.co/lyAVapQH6f

Dr. John Cush @RheumNow (  View Tweet)

Jan 22, 2021
Metanalysis of Rituximab use in EGPA (Churg-Strauss) found 19 cohort studies, 8 case series, 18 cases, for a total of 368 EGPA patients.
Dr. John Cush @RheumNow (  View Tweet)
Jan 22, 2021
Seronegativity in RA studied using sera and microarrays from 559 RA (283 ACPA-) found 9 autoAbs w/ >90% specificity for seroneg RA.
Dr. John Cush @RheumNow (  View Tweet)
Jan 22, 2021
Mortality Risk in Rheumatoid Lung Patients A Medicare claims analysis of rheumatoid arthritis (RA) patients showed that RA-associated interstitial lung disease (RA-ILD) was seen in nearly 5% of patients and was found to increase mortality risks. Read on: https://t
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Jan 22, 2021
Metanalysis RCTs of Antidepressants in painful conditions (LBP, sciatica, hip/knee OA) shows SNRIs (Cymbalta, Savella, Effexor etc) have a small & not clinically important for effect on back pain.
Dr. John Cush @RheumNow (  View Tweet)
Jan 22, 2021
QD Clinic - Smoking and RA: The dastardly, nastardly facts of smoking and RA https://t.co/H4jeFIXeGq https://t.co/xWxjzGZWQq
Dr. John Cush @RheumNow (  View Tweet)
Jan 22, 2021
In the UK, NICE has recommending ed (to NHS) that filgotinib (Jyseleca) be approved for use in moderate to severe active rheumatoid arthritis (RA).https://t.co/g5zLwIa3MK

Dr. John Cush @RheumNow (  View Tweet)

Jan 22, 2021

NEJM: Early Combo Monoclonal Antibody Therapy in COVID-19

Jan 21, 2021

NEJM has published the interim analysis of the REGN-COV2 trial, wherein an antibody cocktail reduced viral loads with less clinical consequences. 

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Combo Anti-Spike Protein Antibody for Mild to Moderate COVID-19

Jan 21, 2021

JAMA has published the BLAZE-1 study, showing significant SARS-CoV-2 viral load reduction at day 11 and less COVID-19 progression when combination anti-spike monoclonal antibody therapy (bamlanivimab and etesevimab) was given to mild to moderate, non-hospitalized COVID-19 patients.

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Don’t hold Benlysta for the COVID19 vaccine! Previous studies have shown that SLE pts on Benlysta (belimumab) still have good antibody response to vaccinations (including Prevnar14, PPSV23, flu and tetanus vaccines). ⁦@RheumNow⁩ https://t.co/4rFdcIKjkT

k dao @KDAO2011 (  View Tweet)

Jan 21, 2021
Canadian lupus cohort of 560 SLE pts without myositis at baseline. Over time, only 5 pts developed myositis (after mean 8.5 yrs). Incidence = 1.05 per 1000 PYs. Arthritis, Raynauds, -Sm Abs were common, but only non-Whites had increased risk of myositis.

Dr. John Cush @RheumNow (  View Tweet)

Jan 21, 2021
NEW QD Clinic Differential Dx Myalgias & Arthralgias https://t.co/ozawoe6RMO

Dr. John Cush @RheumNow (  View Tweet)

Jan 21, 2021
Denosumab inhibiting osteolysis? 22 pts undergoing revision THR surgery for osteolysis, 10 Rx w/ denosumab had 83% fewer osteoclasts @ osteolysis membrane–bone interface.

Dr. John Cush @RheumNow (  View Tweet)

Jan 21, 2021
Ehlers-Danlos Syndrome pts have higher association with GI conditions (IBS, etc OR =3.57), POTS & Autonomic dysfunction (OR=4.4), food allergy (OR= 3.9), CV complications (OR 6.1; MV dx, aortic aneurysm), longer hospitalizations (OR= 1.76) https://t.co/noobvrx0c

Dr. John Cush @RheumNow (  View Tweet)

Jan 21, 2021
Though provoking piece by Dr. Len Calabrese in Healio,He references Drs. Schett and Scher writing in Nature Reviews Rheumatology on KOLs. Both articles are about reflection on what we do, how we do it, what motivates us.

Dr. John Cush @RheumNow (  View Tweet)

Jan 21, 2021
Swedish Armed Forces study suggests the least fit are at greatest risk for developing psoriasis later inlife. From 1968 -2005 1,886,542 military recruits were followed mean 31 yrs.

Dr. John Cush @RheumNow (  View Tweet)

Jan 21, 2021
Factors Predictive of SLE Flare After HCQ Taper/Discontinuation The benefits of hydroxychloroquine in lupus are many, but what if you were to withdraw HCQ? Read more: https://t.co/r5iDXBEuQP https://t.co/LImqA9y8Dn
Dr. John Cush @RheumNow (  View Tweet)
Jan 21, 2021
Epidemiologic study of #SLE from CDC & lupus registries estimates there are 204,295 SLE pts in USA (2018).

Dr. John Cush @RheumNow (  View Tweet)

Jan 21, 2021
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