Uncommon Misdiagnosis of Rheumatoid Arthritis
Sep 28, 2022
Recent News
Read ArticleUsing long-term patient data from the BARFOT study of early rheumatoid arthritis (RA) patients, researchers at the Karolinska Institute have shown that use of the ACR-1987 classification criteria was highly precise.
US Opioid Crisis Cost $1.5 Trillion
Sep 29, 2022
Reuters has reported the results of a Congressional report showing the economic toll of the opioid addiction and overdose crisis on the United States reached nearly $1.5 trillion in 2020 alone and is likely to grow.
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#Gout Guidelines--> great outcomes! French study of 300 pts; 95% followed French Rx Guidelines, T2T SU < 6 mg/dL in 59% @6mos, 79% @24 mos & @2 yrs hald were Rx w/ allopurinol (313 mg/d) and 48% febuxostat (84 mg/d) https://t.co/iQ9NvHJXd8 https://t.co/2tkBWrHY32
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Sep 29, 2022
"Double blind" an interesting read (Ann Int Med) of early COVID w/ no known effective therapy, doctor trepidation & and the bravery/will of sick ICU COVID pts as they consent to to enroll in the blinded ACTT trial w/ remdesivir https://t.co/N2bZq0JDmn https://t.co/iPLnNtQoER
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Sep 29, 2022
New download available!
What to do about information overload in medicine.https://t.co/XtJvWOAfA1 https://t.co/RFMRz7vxMY
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Sep 29, 2022
Efficacy and Safety of JAK Inhibitors in Psoriatic Disease
Sep 28, 2022
There is a growing body of evidence demonstrating efficacy and safety of JAK inhibitors in patients with moderate-to-severe psoriasis and psoriatic arthritis, according to a systematic review in BMC Rheumatology.
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Study of 67 OA TKR pts looked for CPPD - defined as "appears as linear/punctate opacities w/in cartilage, synovium, Jt capsule or tendons/entheses". Xrays had specificity of 92%, sensitivity 54%, PPV 88%, NPV 66% (needs to be distinguished from BCP) https://t.co/Nd9FZKyOHy https://t.co/m9PYofGE04
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Sep 28, 2022
Long term results of KEEPsAKE 1 and 2, RCTS of SKYRIZI (IL-23 inhibitor) in active #PsA pts were presented at EADV mtg in Milan. At wk 100, showed more than half of PsA patients achieved PASI 90 & ACR 20 responses. https://t.co/5upWNItwGy https://t.co/RMwDYVubOk
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Sep 28, 2022
Metanalysis of 57 studies, 227,812 RA & 64,290 OP pts. Finds the OP prevalence in RA to be 27.6% (95%CI 23.9–31.3%). Despite significant advances in prevention, treatment & imaging, OP prevalence remain high. https://t.co/SxAJ8cGU8b https://t.co/91D6rtW9bF
Sep 28, 2022
NSAIDs Linked to Heart Failure in Diabetes Patients
Sep 27, 2022
Short-term use of non-steroidal anti-inflammatory drugs (NSAIDs) is associated with a first-time hospitalisation for heart failure in patients with type 2 diabetes, according to research presented at ESC Congress 2022.
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Are We Overcautious With TNF Inhibitors in Pregnancy?
Sep 27, 2022
What may seem like a prudent approach to treatment of inflammatory bowel disease (IBD) in pregnant women actually represents an overabundance of caution, suggested researchers who found no increased risk from tumor necrosis factor (TNF) inhibitors.
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3 Large cohort (OAI, MOST, CHECK) looked at 9683 knees (incidence cohort) & 6075 knees (progression cohort) showing increase in BMI assoc w/ incidence (OR 1.05) & progression (1.05). BMI also assoc w/ degeneration & JSN hip & medial knee https://t.co/VAU2UJRQ8O https://t.co/QBl2wt0FrN
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Sep 27, 2022
Is there a link between PsA & autoinflammatory disease? Dr. Cush reviews a recent study of 120 #PsA patients in our latest podcast.https://t.co/b15zmfXACa https://t.co/aCY08xXtPw
Sep 27, 2022
ASBMR 2022 study shows Patients w/ serum ferritin > 1000 µg/L or Dx hemochromatosis or thalassemia — were 60% more likely to have an osteoporotic fracture (2X risk vertebral Fx) during an up to 10-year follow-up https://t.co/uLf8zTiMml https://t.co/9KnApUxxTF
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Sep 27, 2022
VTE Risk from Swedish Rheumatology Quality Register - VTE Prevalnce/1000PY TNFi 5.15; JAKi 11.33; Gen Pop 3.3. VTE adj HR JAKi vs TNFi =1.73 (1.24, 2.42); PE HR 3.21 (2.11, 4.88) and DVT HR 0.83 (0.47,1.45) https://t.co/WclcFpX3aI https://t.co/r1FXSZNcYJ
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Sep 27, 2022
Immune Benefits to Sound Sleep
Sep 26, 2022
The revitalizing powers of sleep are numerous but what are the consequences to inadequate sleep? A current report in the Journal of Experimental Medicine shows the connection between sleep and immune function as measured in mice and humans; specifically, a good night’s sleep promotes normal production and programming of hematopoietic stem cells.
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Rheumatology Leaders and Patient Advocates Convene on Capitol Hill
Sep 26, 2022
ACR members along with rheumatology patients gathered on Capitol Hill and urged federal lawmakers to support the HELP Copays Act, Safe Step Act, and Improving Seniors’ Timely Access to Care Act.
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Analyses of data from the Nurses Health Study (1986-2016) & NHSII (1989-2017) cohorts shows chronic low sleep duration (< 5hrs/night vs >7hr/night) was assoc w/ increased SLE risk (adj HR 2.47). Low sleep also assoc w/ body pain(2.13), depression(HR 2.82) https://t.co/I9oCDQyulz https://t.co/vjRFDXf0EZ
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Sep 26, 2022
IL-18 is a proinflammatory cytokine involved in innate &adaptive immune responses. IL-18 is a key mediator in autoinflammatory diseases, MAS, Still’s disease. Serum IL-18 levels may be useful in diagnosis and monitoring of disease activity https://t.co/IB9CwbILD9 https://t.co/TWNnjJyR2Z
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Sep 26, 2022
Medicare (1,654,862 pts) cohort matched study included 3.6% w/ rheumatic IMIDs w/ MI. Rheum IMIDs were younger, women, w/ non–STEMI, less angiography/Stent/CABG & have higher mortality (aHR 1.15), CHF (1.12) & recurrent MI (1.08) https://t.co/SxemjO7GA2 https://t.co/VKg1f4yd2M
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Sep 26, 2022
Cancer Risk with Scleroderma
Spanish Scleroderma Registry examined a large cohort of systemic sclerosis (SSc) patients showing an increased cancer risk, especially breast, lung, hematologic and colorectal cancer.https://t.co/9w53NO3AsU https://t.co/bSkFhTN3v2
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Sep 26, 2022
From the blog
Still's disease: paediatrics to adults, a continuum or not?
Dr. Ilenia Di Cola and Dr. Piero Ruscitti
Jul 25, 2022
Still’s disease is a rare inflammatory disorder, affecting less than 1 person per 2000 people. This disease may occur in both children and adults, namely as systemic juvenile idiopathic arthritis (sJIA) and adult-onset Still’s disease (AOSD).
The paediatric form was described by George Still in 1896, whereas the adult variant later by Eric Bywaters in 1971. However only the adult disease is identified by the name of Still.
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Podcasts
Heavy Metal Rheumatology (9.23.2022)Sep 23, 2022- CD19 CAR T Cell Therapy In SLE (9.16.2022)Sep 16, 2022
- Does Fibromyalgia Need B12Sep 09, 2022
StillsNow Podcast August 2022 - Genetic Testing for Autoinflammatory DiseasesSep 06, 2022- Goofy But True (9.2.2022)Sep 02, 2022
Therapeutic Updates
A Rheum & Derm Perspective on Treating PsA and Moderate-to-Severe PsO
Sponsored by Lilly USA
Sep 01, 2022
Dr. Mease and Dr. Armstrong discuss a multidisciplinary approach and important considerations when treating patients with joint and skin concerns. Ages 18+; for HCPs only.
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