RheumNow Podcast – Don’t Hold the Benlysta, Take the Vaccine (1.22.2021)
Jan 22, 2021
Recent News
Dr. Jack Cush reviews the news and journal articles from the past week on RheumNow.com, with more than a dozen items to discuss on this week's podcast.Read Article
Today is the PDUFA date wherein the FDA decides the fate of Aurinias calcineurin inhibitor, Voclosporin, use in lupus nephritis. https://t.co/6du61xGrDq https://t.co/2knPWyNmu4
Dr. John Cush @RheumNow ( View Tweet)
Jan 22, 2021
COVID Vaccine Q & A - Dr Kevin Winthrop
Dr. Cush interviews Dr.
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Jan 22, 2021
MMWR reports 10 cases of anaphylaxis after 4 million doses of Moderna COVID-19 vaccine (2.5 cases per million doses administered). 9/10 occurred within 15 minutes of vaccination. No anaphylaxis-related deaths were reported. https://t.co/lyAVapQH6f
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Jan 22, 2021
Metanalysis of Rituximab use in EGPA (Churg-Strauss) found 19 cohort studies, 8 case series, 18 cases, for a total of 368 EGPA patients.
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Jan 22, 2021
Seronegativity in RA studied using sera and microarrays from 559 RA (283 ACPA-) found 9 autoAbs w/ >90% specificity for seroneg RA.
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Jan 22, 2021
Mortality Risk in Rheumatoid Lung Patients
A Medicare claims analysis of rheumatoid arthritis (RA) patients showed that RA-associated interstitial lung disease (RA-ILD) was seen in nearly 5% of patients and was found to increase mortality risks.
Read on: https://t
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Jan 22, 2021
Metanalysis RCTs of Antidepressants in painful conditions (LBP, sciatica, hip/knee OA) shows SNRIs (Cymbalta, Savella, Effexor etc) have a small & not clinically important for effect on back pain.
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Jan 22, 2021
QD Clinic - Smoking and RA: The dastardly, nastardly facts of smoking and RA
https://t.co/H4jeFIXeGq https://t.co/xWxjzGZWQq
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Jan 22, 2021
In the UK, NICE has recommending ed (to NHS) that filgotinib (Jyseleca) be approved for use in moderate to severe active rheumatoid arthritis (RA).https://t.co/g5zLwIa3MK
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Jan 22, 2021
NEJM: Early Combo Monoclonal Antibody Therapy in COVID-19
Jan 21, 2021
NEJM has published the interim analysis of the REGN-COV2 trial, wherein an antibody cocktail reduced viral loads with less clinical consequences.
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Combo Anti-Spike Protein Antibody for Mild to Moderate COVID-19
Jan 21, 2021
JAMA has published the BLAZE-1 study, showing significant SARS-CoV-2 viral load reduction at day 11 and less COVID-19 progression when combination anti-spike monoclonal antibody therapy (bamlanivimab and etesevimab) was given to mild to moderate, non-hospitalized COVID-19 patients.
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Don’t hold Benlysta for the COVID19 vaccine!
Previous studies have shown that SLE pts on Benlysta (belimumab) still have good antibody response to vaccinations (including Prevnar14, PPSV23, flu and tetanus vaccines).
@RheumNow https://t.co/4rFdcIKjkT
k dao @KDAO2011 ( View Tweet)
Jan 21, 2021
Canadian lupus cohort of 560 SLE pts without myositis at baseline. Over time, only 5 pts developed myositis (after mean 8.5 yrs). Incidence = 1.05 per 1000 PYs. Arthritis, Raynauds, -Sm Abs were common, but only non-Whites had increased risk of myositis.
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Jan 21, 2021
NEW QD Clinic
Differential Dx Myalgias & Arthralgias
https://t.co/ozawoe6RMO
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Jan 21, 2021
Denosumab inhibiting osteolysis? 22 pts undergoing revision THR surgery for osteolysis, 10 Rx w/ denosumab had 83% fewer osteoclasts @ osteolysis membrane–bone interface.
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Dr. John Cush @RheumNow ( View Tweet)
Jan 21, 2021
Ehlers-Danlos Syndrome pts have higher association with GI conditions (IBS, etc OR =3.57), POTS & Autonomic dysfunction (OR=4.4), food allergy (OR= 3.9), CV complications (OR 6.1; MV dx, aortic aneurysm), longer hospitalizations (OR= 1.76) https://t.co/noobvrx0c
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Dr. John Cush @RheumNow ( View Tweet)
Jan 21, 2021
Though provoking piece by Dr. Len Calabrese in Healio,He references Drs. Schett and Scher writing in Nature Reviews Rheumatology on KOLs. Both articles are about reflection on what we do, how we do it, what motivates us.
Dr. John Cush @RheumNow ( View Tweet)
Jan 21, 2021
Swedish Armed Forces study suggests the least fit are at greatest risk for developing psoriasis later inlife. From 1968 -2005 1,886,542 military recruits were followed mean 31 yrs.
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Dr. John Cush @RheumNow ( View Tweet)
Jan 21, 2021
Factors Predictive of SLE Flare After HCQ Taper/Discontinuation
The benefits of hydroxychloroquine in lupus are many, but what if you were to withdraw HCQ?
Read more: https://t.co/r5iDXBEuQP https://t.co/LImqA9y8Dn
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Dr. John Cush @RheumNow ( View Tweet)
Jan 21, 2021
Epidemiologic study of #SLE from CDC & lupus registries estimates there are 204,295 SLE pts in USA (2018).
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Dr. John Cush @RheumNow ( View Tweet)
Jan 21, 2021
From the blog
Zoomatology – Present in Absentia
Jan 06, 2021
Are you a zoomatologist or a doomsatologist? Zoom has replaced the meeting, the teleconference or the board meeting. If your old meetings were bad, then your replacement zoom meetings will also be bad, if not worse. Largely because you have failed to master the medium. Here are the new rules of Zoom.
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20,21 Whatever it Takes
Jan 05, 2021
Amazingly, we made it through 2020, a most forgettable year.
Life was great in the first 3 months of 2020, and then COVID hit the fan and a pandemic steamroller derailed life as we knew it.
Eventually we witnessed that lives either improved or worsened. Bartenders are out of a job, but teachers and nurses are busy morphing their skillsets. Some patients skipped out of visits, testing and medical plans. Yet, others exercised, lost 20 lbs. and signed up for telemedicine visits.
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ACR Fireside Chats - Still's disease AbstractsJan 01, 2021
Therapeutic Update
ACR Convergence 2020 Fireside Chats – Top Abstracts in nr-axSpA, AS, axial PsA and Still’s disease
Sponsored by Novartis Medical Affairs
Jan 01, 2021
