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Rethinking Treatment of EGPA

Eosinophilic granulomatosis with polyangiitis (EGPA) has long been managed by extrapolating results from microscopic polyangiitis and granulomatosis with polyangiitis clinical trials. But new insights into EGPA's has lead to advances in therapy and new treatment paradigms.

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Arrhythmias in Autoimmune Rheumatic Disease A new review in the Journal of Cardiovascular Development and Disease (Tamirisa et al) synthesizes how SLE, RA, and SSc have an increased risk of arrhythmias and SCD attributable to shared immune pathways. These facts substantiate the https://t.co/CSkRW7JRr1
Dr. John Cush @RheumNow (  View Tweet)
Best proof of difference betw Seropos vs seroneg RA from TREAT-EARLIER 12 mos study 236 clinically suspect arthralgia pts w/ subclinical Jt inflammation Rx w/ MTX vs PBO. MTX prevented RA only the seroneg RA (9 v 35%); But no protection in seropos RA (58 vs 65%) https://t.co/A5aFUgMPQR
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Keep HCQ Blood Levels Up to Avoid Cardiovascular Disease in Lupus

MedPage Today

People taking hydroxychloroquine (HCQ) for systemic lupus erythematosus (SLE) showed markedly increased risk for atherosclerotic cardiovascular disease when blood levels of the drug were low and when long-term adherence was poor, a prospective study showed.

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Top 20 Best Rheumatology Hospitals

U.S. News & World Report has published its Best Hospitals for 2026-2027, listing the best among many specialties, including rheumatology.  Each year U.S. News Best Hospitals ranked hospitals in the U.S. in 14 adult specialties and for the 9th year in a row, Johns Hopkins Hospital in Baltimore has been named the top hospital for rheumatology.

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COLIPSO prospective study of psoriasis or psoriatic arthritis adults starting ts/bDMARDs; MRI done serially. 35 pts f/u for ~29 wks - MASLD. Only Rx w/ IL-17 inhibitors improved liver fat and inflammation in psoriatic disease as well as clinical outcomes. https://t.co/uHO8ldjLKJ https://t.co/RqKK5JCANt
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Four Decades of Gout Management During this month-long campaign on Gout, we have documented many significant changes in our approach to gout, as well as many unmet needs and deficiencies that merit our continued primary attention. https://t.co/ddzj3RktDD https://t.co/x7o0HfWqHa
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JAMA Review of Hip Fracture The July 16th edition of JAMA reviews the highly prevalent problem of hip fractures - a major global health burden: 14.2 million occur worldwide annually (280,000 in the US), with global incidence higher in women (833.9/100,000) than men https://t.co/TiiCjoq2Hj
Dr. John Cush @RheumNow (  View Tweet)
New, Advanced Therapies in Gout New, Advanced Therapies in Gout explores the rapidly evolving therapeutic landscape beyond conventional urate-lowering therapy. https://t.co/0uNK0nOEp6 https://t.co/YD7tQu2QrT
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U Alberta Rheumatology study of GCAPS score in 62 new onset, suspected GCA referrals. GCA Dx in 39 pts excluded in 23. 50% had a High risk GCAPS (screening) score, 38% Intermediate & 13% had Low risk GCAPs. Intermediate or High risk GCAPS sensitivity 97%, specificity 30%, PPV 70% https://t.co/HxHL60VAuO
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In a Cohort of 410 #SLE pts, there were 37 MALES who demonstrated a high prevalence of renal (IV/V lupus nephritis 49%) and a notable incidence of Plaquenil-related retinal toxicity. 62% on HCQ, but 22% D/C HCQ due to retinal toxicity or drug intolerance. https://t.co/FcIFxRoZ6O https://t.co/7OgexLYWge
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A Tribute to Daniel L. Kastner, MD, PhD (1951–2026)

The rheumatology, genetics and NIH communities mourn for Dr. Daniel L. Kastner, who died on July 28, 2026, in Bethesda, Maryland, at age 74. The following are declarations, tributes, and memories dedicated to this mensch of a man, titan of science, memorable mentor and humble physician.

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💡 JAMA Insights: #SleepHealth and #obesity are linked, with insufficient sleep quantity and poor sleep quality associated with weight gain, less healthy diet, and incident obesity. https://t.co/SEj9dwNHiW https://t.co/JbPah4BwDr
QD Clinic: Addressing Severe Gout Flares Dr. Eric Dein, Summit, NJ, discusses a difficult-to-treat case of gout. https://t.co/tochY0BUBj https://t.co/9hQ13cDY9s
Dr. John Cush @RheumNow (  View Tweet)
Retrospective study, 41 pediatric Behcets Dz pts looked at Inflam. indices (NLR, SII, PIV, CRP/albumin) vs controls. BD systemic involvement in 68%, CNS dz in 10%, Vascular Dz in 12% & major organ dz 46%. Inflamm indices significantly higher in BD w/ systemic, CNS, & Vasc https://t.co/wHiBIaOWWU
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Gout & Metabolic Syndrome Dr. John Fitzgerald, Los Angeles, hates the expression "It's only Gout." https://t.co/0JipL3kgcM https://t.co/jszxYAfZwa
Dr. John Cush @RheumNow (  View Tweet)
Four Decades of Gout Management During this month-long campaign on Gout, we have documented many significant changes in our approach to gout, as well as many unmet needs and deficiencies that merit our continued, primary attention. https://t.co/pTcEtEfQtc https://t.co/yK79xyrEHI
Dr. John Cush @RheumNow (  View Tweet)
Treatment goals in gout: aim for remission! Rheumatologists are used to the concept of disease remission as this is a treatment goal we use for many chronic rheumatic diseases in our clinical practice. Recently, G-CAN (the Gout and Crystal Arthritis Network), endorsed a https://t.co/PP2NBqvo7E
Dr. John Cush @RheumNow (  View Tweet)
New Avacopan Analysis Sent to FDA After data manipulation allegations, the FDA has been calling for the vasculitis drug to be pulled from the market since January. Amgen has submitted a third-party review of avacopan's (Tavneos) pivotal trial data and other analyses to the FDA https://t.co/TdLWRMPvnR
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