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Vedolizumab Promising in Immune-Related GI Events

Oct 27, 2020

Vedolizumab (Entyvio) was superior to infliximab (Remicade) for treating immune-mediated diarrhea and colitis (IMDC), a researcher reported.

In a retrospective study of patients with cancer, treatment with vedolizumab led to a 13% IMDC recurrence rate versus 28% with infliximab, according to Yinghong Wang, MD, PhD, of the MD Anderson Cancer Center in Houston.

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New research shows potential utility of plasma specialized pro-resolving mediator (SPM; like RvD4, 10S, 17S-diHDPA, 15R-LXA4 and MaR1n-3 DPA) concentrations as biomarkers to predict DMARD responsiveness in #RA. https://t.co/WQb57EON10

Dr. John Cush @RheumNow (  View Tweet)

Oct 27, 2020

Immune Necrotizing Myopathy

Oct 26, 2020

A full read review of immune-mediated necrotizing myopathy is portrayed as a distinct subtype of inflammatory myopathies first described in 2004.

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Telemedicine Outcomes in RA Care

Oct 26, 2020

A new short‐term follow‐up study has shown no significant difference in outcomes and quality measures in patients with RA who were managed by telemedicine (compared to usual in-person care).

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Review of 127 pts w/ diagnostic criteria for palindromic rheumatism - Most affected JTS were wrist, knee, MCP; 34% later developed CTD (28% RA, 2% lupus 3% other CTD). Progression predicted by +RF (HR 2.9), PIP (HR 2.4), Wrist (HR 2.5) & female (HR 2.2)

Dr. John Cush @RheumNow (  View Tweet)

Oct 26, 2020
Safety of nintedinib (NIN)in PSS-ILD - 576 PSS pts given NIN 150 mg bid or PBO x52wks. Dose lowered to 100 mg bid for AE. Diarrhea seen in 76% of NIN and 32% in PBO (d/c in 6.9% & 0.3%). Dose reduction in 48% & 12%.

Dr. John Cush @RheumNow (  View Tweet)

Oct 26, 2020
PI facts: did you know that JAK inhibitors(UPA, Bari, Tofa) have a warning against use w/ severe liver problems. They have not been studied in pts w/ Hepatitis B or C.

Dr. John Cush @RheumNow (  View Tweet)

Oct 26, 2020
Listent to QD Clinics - A Podcast Weekly Compilation - Lessons from the clinic. Dr.

Dr. John Cush @RheumNow (  View Tweet)

Oct 25, 2020
RheumNow Podcast is up!

Dr. John Cush @RheumNow (  View Tweet)

Oct 25, 2020

FDA Hearing on COVID-19 Vaccines

Oct 23, 2020

Yesterday the Food and Drug Administration's (FDA) "Vaccines and Related Biological Products Advisory Committee" convened a panel of experts to assess the development of vaccines for COVID-19 infection.

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RheumNow Podcast – Back Talk: Questions from Listeners (10.23.20)

Oct 23, 2020

Dr. Jack Cush reviews the news, journal reports, survey results and "Back Talk" questions from Rheums.

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Population study of 11 million, shows incidence of OPTIC NEURITIS is 3.7 /100K Pt-Yrs. Strongest association with multiple sclerosis (MS) and weaker associations with Behçet disease, sarcoidosis, and Sjögren syndrome. https://t.co/LVw0fcq1F1

Dr. John Cush @RheumNow (  View Tweet)

Oct 23, 2020
Randomized trial of 491 probable nonhospitalized COVID-19 pts shows that HCQ (given 800 mg, followed by 600 mg in 6 -8 hrs, then 600 mg qd x 4d) or placebo shows no reduction in symptom severity in outpatients with early, mild COVID-19.https://t.co/yVWGRr6jfr

Dr. John Cush @RheumNow (  View Tweet)

Oct 23, 2020
How are you consuming Virtual CME Rheumatology conferences

Dr. John Cush @RheumNow (  View Tweet)

Oct 23, 2020
Working on an Endocarditis for the Rheumatologist podcast. fast facts!!! 1️⃣ 20% no fever 2️⃣ 20% joint pain at presentation 3️⃣ >40% splenomegly 4️⃣ 90% anemia 5️⃣ most common rash = petechiae (Osler node/janeway/Roth spots 10% combined!) #rheumatology #cleclinicrheum #immunology

Adam J Brown @AdamJBrownMD (  View Tweet)

Oct 23, 2020

High Burnout Rates Among Rheumatologists

Oct 22, 2020

Bergman and colleagues have studied a large cohort of US rheumatologists and found that nearly half meet at least one criterion defining "burnout" among physicians.

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Remdesivir FDA Approved for Hospitalized COVID-19

Oct 22, 2020

The FDA has approved Gilead Sciences Inc’s antiviral drug remdesivir for treating patients hospitalized with COVID-19, making it the first and only drug approved for the disease in the United States.

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FDA approved its 1st drug to treat COVID-19 - the antiviral drug Veklury (remdesivir) for for acute care treatment of COVID-19 requiring hospitalization. Approval based on 3 clinical trials showing clinical improvement, but no change in mortality rates.

Dr. John Cush @RheumNow (  View Tweet)

Oct 22, 2020
Study from China finds that hemophagocytic lymphohistiocytosis (HLH) was a rare (4.2%) but fatal (77.8%) complication in myositis patients (DM, PM, or CADM). Risk factors include baseline Dz activity, worsening ILD and infection https://t.co/QDN1DYzl5p

Dr. John Cush @RheumNow (  View Tweet)

Oct 22, 2020
How are you consuming Virtual CME Rheumatology conferences

Dr. John Cush @RheumNow (  View Tweet)

Oct 22, 2020
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