Skip to main content

Recent News

LRA Awards for Immune Resetting Therapies in Lupus

Lupus Research Alliance

 Lupus Research Alliance (LRA), the world’s largest private funder of lupus research, in collaboration with Genentech, a member of the Roche Group, announced the inaugural recipients of the Lupus Research Alliance-Genentech Award on Immune Resetting Therapies for Lupus (LGA-IRT). The new program aims to deepen our

Read Article
US Biobank (n=480K) study of mobile phone use. W/ 13.6 yrs F/U, 6082 new RA. Cell phone use incr incident RA 14% (HR: 1.14; 1.07–1.23); w/ 8% risk (HR: 1.08) if used >30 min/wk. Speakerphone use was NS. https://t.co/U7TcyoY5SS https://t.co/kqqnFXwaEi
Dr. John Cush @RheumNow (  View Tweet)
Population cohort study of pregnancies from UK Clinical Practice Research Datalink, 5.2 million pregnancies, ~2.5 mill births. Incr risk for miscarriage in Sjögrens (aRR 1.66), C-sect in IBD (1.27), SGA in SLE (2.45), preterm birth in RA (1.53), stillbirth in SLE (1.82) & more https://t.co/IjtRTE2t78
Dr. John Cush @RheumNow (  View Tweet)
RHEUM SURVEY> Per 2024 EULAR Guidelines, an active RA pt on MTX who fails a 1st TNFi, should next change to ?

Dr. John Cush @RheumNow (  View Tweet)

VACIMRA RCT in 249 RA pts on MTX were PCV13 vaccinated & continued or held MTX x 4wks. Best humoral responses w/ holding MTX x4wks with no clinical detriment over next 12 mos (remission, LDA, Xray outcomes) https://t.co/b6ByOYY0Fi https://t.co/XeJURKLpL8
Dr. John Cush @RheumNow (  View Tweet)
30 yr Retrospective study of 1216 SLE hospitalizations in Barcelona - SLE flares & infections were most frequent. Hosp for infections signif. increased & in last 5yrs, exceeded Dz flares (34% vs. 26%). Younger pts had more flare hosp; older more infx hosp. Over time infx have https://t.co/TkUiXaoL1R
Dr. John Cush @RheumNow (  View Tweet)

RepurpSS-II: Hydroxychloroquine plus Leflunomide in Sjögren's

A small, pilot, phase 2b trial has shown that the combination of leflunomide and hydroxychloroquine (LEF+HCQ) was effective and safe in treating patients with active Sjögren's disease.

Read Article

Trends and Innovations in Lupus Nephritis Clinical Trials

Xu et al. from Shanghai University have written an analysis of global lupus nephritis (LN) clinical trials and call for innovation.

Read Article
RHEUM SURVEY> Per 2024 EULAR Guidelines, an active RA pt on MTX who fails a 1st TNFi, should next change to ?

Dr. John Cush @RheumNow (  View Tweet)

An IL-23i through ~5 years: How did clinical manifestations of PsA and radiographic progression change during long-term treatment? 🔥View the latest long-term data from ACR to find out more. Sponsored by AbbVie Medical Affairs + Health Impact. https://t.co/jejeZwo6is https://t.co/MjceThnjnE
Dr. John Cush @RheumNow (  View Tweet)
Quiz Talk (5.22.2026) Dr. Jack Cush talks of birthdays, quizzes, and journal articles this week on the podcast. https://t.co/LwX0XxgPhn https://t.co/4uVTQo6NLG
Dr. John Cush @RheumNow (  View Tweet)
BE BOLD Week 16 data - Bimekizumab vs. Risankizumab in PsA UCB has released the Week 16 results from BE BOLD trial that will be presented at EULAR 2026 in London on Saturday, June 6. This head-to-head trial demonstrates that at week 16, bimekizumab (BKZ) yielded superior ACR50 https://t.co/VVBaNdWIuQ
Dr. John Cush @RheumNow (  View Tweet)
The safe/right choice is H. Zoster. You never fully eradicate invasive fungal or NTM infections. HBV is too risky to again use TNFi again. After H.zoster is Rx,there is evidence its safe to restart TNFi without risk of recurrence. Vagal N. Stim is the mechanistically same as

Dr. John Cush @RheumNow (  View Tweet)

Retrospective Intl SSc study of MD & PT telangiectasia counts (TC) (0, 1–6, 7–15 or > 15) of face, forearms & hands. High TC correlated w/ PAH (AUC 0.824–0.875) & digital ulcers. Moderate agreement betw MD & Pt for face & forearms TC (kappa 0.648 & 0.605, p< 0.001) https://t.co/jtHgVABFiA
Dr. John Cush @RheumNow (  View Tweet)
Case-control study of 349 autoimmune (ARD) pts (SLE, RA, SSc) & serum assays for anti-neutrophil extracellular trap (aNET)Abs. aNET in 37% SLE assoc w/ APS (OR 3.4) & arterial thrombosis (OR 5.5). aNET in 40% RA assoc w/ ACPA+ (p=0.049) https://t.co/QwvmLAVmg7 https://t.co/VJ7JV5fcZE
Dr. John Cush @RheumNow (  View Tweet)
Best JAKi? Italian Observational BIRRA Cohort study of 170 #PsA pts Rx w/ UPA or TOFA found no significance in 6 mos (86 vs 78%) or 12 mos (68 v 60%) retention. Persistence lower in pts Concomitant or later csDMARDs. https://t.co/vtSrO9orh4

Dr. John Cush @RheumNow (  View Tweet)

Canada’s Drug Agency (CDA-AMC) has recommended Gazyva (obinutuzumab) for public reimbursement. This recommendation is for the treatment of adult patients with active lupus nephritis who are receiving standard therapy https://t.co/TC1MVAShdC https://t.co/flXVmLwGtW
Dr. John Cush @RheumNow (  View Tweet)
"Courage is resistance to fear, mastery of fear, not absence of fear." - Mark Twain https://t.co/xyJqiV7biI
Dr. John Cush @RheumNow (  View Tweet)
RHEUM Survey: After treating which infection can you safely resume anti-TNF therapy?

Dr. John Cush @RheumNow (  View Tweet)

×