Hydroxychloroquine as Postexposure Prophylaxis for COVID-19 Fails
Jun 04, 2020
Recent News
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Read ArticleNEJM has reported that the use of hydroxychloroquine did not prevent symptomatic COVID-19 infection when used within 4 days after SARS-CoV-2 exposure.
Open label, uncontrolled study shows that background use of azathioprine (2mg/kg) in Pegloticase treated refractory gout patients was partly effective - 6/12 completed, 2 still on Rx, 2 PEG ineffective and 2 side effx #EULAR2020 #Gout Abst#THU0410 https://t.co/APZRP
Links:
Dr. John Cush @RheumNow ( View Tweet)
Jun 04, 2020
TNR Grand Rounds - Update on Biosimilars
Jun 03, 2020
This week's Tuesday Nite Rheumatology featured Dr Jonathan Kay (U Mass) who gave an update on Biosimilars and took questions the subject. The program was moderated by Dr. Jack Cush.
Read Article
Use of HCQ was not associated with development of ❤️Heart Failure in patients with RA. There was no statistically significant association between the cumulative dose of HCQ & HF. A good study from #MayoClinic. #EULAR2020 #eular20 https://t.co/yG03e0TAcV
Mario Pompermayer, MD @pompermarioMD ( View Tweet)
Jun 03, 2020
ILD RA has more hospital admissions. Occurs in 14% of RA. Increased mortality. Serious complication of RA @eular_org @RheumNow @CRASCRRheum @earlyarthritis #EULAR2020 OP0039 https://t.co/2N3tulzq3R
Janet Pope @Janetbirdope ( View Tweet)
Jun 03, 2020
Nice surprise as IL23 Guselkumab works not only in PsA but axial PsA. Another Rx option also presented at @eular_org #EULAR2020 @CRASCRRheum @earlyarthritis https://t.co/dUqqagzbeC
Janet Pope @Janetbirdope ( View Tweet)
Jun 03, 2020
Can machine learning/AI predict who will respond & get remission in RA prior to bDMARD? High dose steroids, older age high ESR long disease duration worse outcomes but not same for each drug.
Janet Pope @Janetbirdope ( View Tweet)
Jun 03, 2020
We're still poor at estimating the chance of remission with bDMARDs for individuals w RA - but maybe AI can help provide them with a personalised prediction of their chances of success?
David Liew @drdavidliew ( View Tweet)
Jun 03, 2020
Tocilizumab in GCA - three year data from GiACTA on steroid exposure and time to flare:
- steroid-sparing benefit persists in both new-onset and relapsing disease
- in avoiding flares, benefit for weekly dosing in both new-onset and relapsing disease
OP0027 #EULAR2020 @RheumNow
David Liew @drdavidliew ( View Tweet)
Jun 03, 2020
"It's a brave new world!" Dr. Iain McInnes, president of #EULAR2020 discussing how the pandemic has created a "technological miracle" by bringing us all virtually together! @RheumNow
Dr. Rachel Tate @uptoTate ( View Tweet)
Jun 03, 2020
Case control study to see if MTX is assoc with ILD in RA. Hypersensitivity pneumonitis pts were excluded. MTX use assoc with DELAYED onset of ILD so protective.
Janet Pope @Janetbirdope ( View Tweet)
Jun 03, 2020
#EULAR2020 OP0026. RITAZAREM. Rituximab superior to Aza 2mg/kg in maintaining remission in relapsing AAV. Flare rate 13% vs 38%. Note Ritux schedule is 1g every 4 months (x 5 infusions out to month 20).
Patrick Kiely @pkiely500 ( View Tweet)
Jun 03, 2020
Can we treat GPA /ANCA vasculitis without steroids? Apparently yes +RCT by P Merkel in #EULAR2020 plenary adding avacopan-blocks C5a. Gutsy move as No steroids in one arm!
Janet Pope @Janetbirdope ( View Tweet)
Jun 03, 2020
Dr. R Landewe highlights #EULAR2020 #COVID19 Guidelines:
1. RMD-patients do NOT have higher risk for complications 2. Rheumatologists SHOULD BE involved in management discussions 3. Potential shortages of sDMARDS and biologics
@rheumnow https://t.co/sjQubD7mJL
k dao @KDAO2011 ( View Tweet)
Jun 03, 2020
Patients with RA-ILD vs RA only: More likely to be older, male, white and RF positive.
Mario Pompermayer, MD @pompermarioMD ( View Tweet)
Jun 03, 2020
SAPHO or PsA with CASPAR criteria? 1/3 of SAPHO pts meet PsA criteria (particularly active or hx of psoriasis). Interestingly, most with osteitis did not meet CASPAR criteria while those with synovitis did. #EULAR2020 @RheumNow #AB0738 https://t.co/G4p6OiocE3
Dr. Rachel Tate @uptoTate ( View Tweet)
Jun 03, 2020
Congratulations from all of us at the BRC to Professor Paul Emery OBE for being awarded a Meritorious Award at EULAR 2020 #EULAR2020goesvirtual #EULAR2020 #FightingRMDsTogether https://t.co/z9T4AZ5P0u
NIHR Leeds BRC @LeedsBRC ( View Tweet)
Jun 03, 2020
Guselkumab improved axial symptoms, over 24 weeks in active PsA patients with radiographic sacroiliitis. Post-hoc analysis from Discover1&2 studies (Prof P Helliwell). #OP0054. #EULAR2020, >GF
ARD & RMD Open @ARD_BMJ ( View Tweet)
Jun 03, 2020
Can fatigue in RA vary by bDMARD used?
David Liew @drdavidliew ( View Tweet)
Jun 03, 2020
17,500 people connected at moment at the largest e-Congress I could imagine #EULAR2020 #EULAR2020goesvirtual
Loreto Carmona 🖖 @carmona_loreto ( View Tweet)
Jun 03, 2020
You've got at least two good reasons not to forget about cardiovascular risk in ankylosing spondylitis.
Traditional and inflammatory: it's the double whammy.
Mike Nurmohamed from @Reade_020 #EULAR2020 @RheumNow https://t.co/GLH7wzvrLN
David Liew @drdavidliew ( View Tweet)
Jun 03, 2020
Recent Podcasts
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![artworks-r4szOJTQx34Ebvpr-ClkfXw-t500x500.jpg]()
TNR Grand Rounds - Update On BiosimilarsJun 04, 2020 -
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RheumNow Podcast - Rheumatic Patients With COVID (5.29.20)May 29, 2020 -
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Virtual Video Joint Exam (Updated)May 28, 2020 -
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TNR Grand Rounds Cytokine Storm SyndromeMay 27, 2020 -
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RheumNow Podcast - Preaching To The Choir (5.22.20)May 22, 2020
From the blog
Faith
Jun 03, 2020
For Jessica, an ICU nurse, 12-hour shifts were usually fast paced, challenging and productive. But the cadence and demands of work abruptly changed mid-March when COVID-19 came.
Amongst her many ICU admissions she took care of Larry, who was instantly interesting and forever memorable. He had contracted the coronavirus less than a week before. He was a 60-ish yr. old man who tried to be humorous, but who was clearly distressed and worried. He was febrile, anxious, breathing hard and on the verge of being unstable.
Read Post
Graduation
May 19, 2020
Congratulations!
Years of training and work, all your efforts and overcoming hurdles have culminated in where you are today – on the verge of a new life, a new plan and possibly a new career.
Therapeutic Update
Treatment Switch Between a JAK Inhibitor (upadacitinib) and TNF Inhibitor (adalimumab) in Patients with RA
Sponsored by AbbVie
Jun 01, 2020
What happens when a patient doesn’t adequately respond to a JAK inhibitor or a TNF inhibitor? This video reviews data from the SELECT-COMPARE study looking at what happens when RA patients who have an insufficient response to a JAK inhibitor (upadacitinib) or TNF inhibitor (adalimumab) switch to the alternate therapy.
Read Post
