De Craemer et al. Local vs Central reading of images. Rheumatologists overcall sacroiliitis on both plain films and MRI in ?AxSpA . ? some of this out of a desire to try something to help someone who is suffering @RheumNow #ACR22 Abstr#1255 https://t.co/j89E0sUPmN https://t.co/Ez5ldSSQJl

• Rheumatologists Overcall Sacroiliitis on X-ray and MRI in Axial Spondyloarthrit…

HZ risk after each (1 of 3) BNT162b2 mRNA vaccination doses was not increased in PsA and AS patients compared to a similar time period two years prior . The risk of HZ increased with age. Abs 1489 #ACR22 @RheumNow https://t.co/YmcqDNoxya

• Incidence of Herpes Zoster Events After the Three Doses of the BNT162b2 mRNA Va…

Once again, high BMI and smoking associated with substantial decrease in TNFi response for treatment of axSpA. Easier said than done however. How are you helping pts lose weight or stop smoking? Abs#1510 @RheumNow #ACR22 https://t.co/ircLkuXhCs

Gut microbiota of axSpA pts who underwent bDMARD tx for one year more closely resembled controls. Unique enrichment of Collinsella in axSpA patients remained stable across time & tx, suggesting it may be a disease biomarker. Abs 1162 #ACR22 @RheumNow https://t.co/SjwORWp6IU https://t.co/rLlu4jGCfd

• Improvement of Gut Microbiota Dysbiosis in Patients with Axial Spondyloarthriti…

GM-CSF inc'd in active AS pts, particularly in younger ages, and strongly correlates with disease activity, but not with disease duration. TNFi tx does not affect GM-SCF levels, despite improving disease activity. Abs 1156 #ACR22 @RheumNow https://t.co/ndhBGbPsCw

• Serum Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) Is Increased in…

Nice study on referral strategies for #axSpA in pts w/ chronic LBP by Dr @Nellziade 🔸MASTER strategy-optimal reference strategy: IBP, ✅NSAID response, HLA-B27+ & +SpA family hx 🔸Clinical predictive factors: uveitis, IBP, Pso, enthesitis &🚹 #ACR22 @RheumNow ABST#1512 #ACRBest https://t.co/l6AleXX7Kt

Decreased colonic mucus production in HLA-B27 + healthy individuals and axSpA and IBD pts. Abs 1151 #ACR22 @RheumNow https://t.co/CwX4n6PJFy https://t.co/4f1Za0Qhpj

• Colonic Organoids to Study the Role of HLA-B27 in Gastrointestinal Epithelial B…

Biologics to treat gut microbiome dysbiosis?? In axSpA pts treated with bDMARDs for one year, gut microbiome resembled those of controls. Collinsella remained stable - possible biomarker? Abs#1162 @RheumNow #ACR22 #ACRBest https://t.co/vmQFJMpNPP

Abs 1153 at #ACR22 males may have a higher levels of Th17-associated transcription factors. Radiographic progression in men may be mediated by S100 proteins and prostaglandins. @RheumNow https://t.co/mWbsaB8kK8 https://t.co/IkTBZcaqa6

• Differentially Expressed Genes in Males and Females with Ankylosing Spondylitis…

Inflammation causing HTN in AS? Abstract #0384 #ACR22 @RheumNow 🫀413 patients followed for median 12 years 🫀14% developed HTN 🫀Baseline disease duration was an independent RF for HTN 🫀ESR > 20 sig. associated with HTN

Ab1011 #ACR22 @SMerjanah: Fracture rates among vets with AS Increasing fx incidence for AS and comparator groups over time There was increase in fractures during TNFi era 2004-2021 compared to pre-TNFi, does not show fx sparing effect @RheumNow https://t.co/fTSYbFcxqo

Abs 1011 examined fracture incidence rates in AS patients over time in VA cohort - Rate of fractures in AS pts 2.1 per 1000 PY --> 22.8 (1999 --> 2021) vs Comparators 0.4 --> 8.3 - Post TNF era fracture rates increased AS > comparators @RheumNow #ACR22 https://t.co/eUxoTavHGV

What delays diagnosis of AS? #ACR22 @RheumNow Abstract #0328 Diagnosed faster if: 👨‍🦳Older age at back pain onset 🧬HLA-B27+ ✋🦶peripheral arthritis 📍Higher socioeconomic vulnerability had diagnostic delay 👁 uveitis more common in patients with > 4 years dx delay

Analysis from Abs 0954 shows that mainly fatigue and back pain have an impact on the mean BASDAI during pregnancy. #ACR22 @RheumNow https://t.co/l5VGKqF2ar https://t.co/fpkl8VRRJP

• What Drives the BASDAI in Pregnant Patients with Axial Spondyloarthritis? A Poo…

Dr PMease et al looked into impact of TNFi cycling in their #axSpA cohort: 💠After 6mos on 2nd TNFi, only 15% had ASDAS-LDA, 7% MCID in ASDAS, 8% >50% improvement 💠Cycling to 2nd TNFi limited benefits ⬇️sample size, worth further investigation #ACR22 @RheumNow ABST#1499 https://t.co/OVJxezdipW