#CurbsideConsult. What would you do? 45 yo female with dSSc and ILD, had been on stable MMF 1500 mg bid. she had increased SOB, new dry cough, hand pain, stiffness.Exam noted synovitis, Labs: ESR 76, Echo RSVP 25 mmHg, HRCT increased ILD compared to a year ago. #ACR22 @rheumnow

Abdel-Wahab et al. TCZ in combo with ipilimumab/nivolumab. Very preliminary results of what will be important trial. Appears safe and well-tolerated with no increased risk cancer progression. @RheumNow #ACR22 Abstr#1670 https://t.co/uPBnHJ9BRH

• Phase II Clinical Trial to Assess the Safety and Efficacy of Tocilizumab in Com…

SAPHYR results: SAR + 14 wk GC taper showed efficacy vs comparator arm in steroid refractory PMR, including clinically meaningful improvement in QoL. No new safety signals. Plenary Abs 1676 #ACR22 @RheumNow https://t.co/mHu3e9JbCp https://t.co/93kbczSTfS

• Sarilumab in Patients with Relapsing Polymyalgia Rheumatica: A Phase 3, Multice…

Ab1672 #ACR22 SSc on Women's Health 100 pts - 75% lSSc 59% sexuality aff by SSc (vag dryness 67%, dig ulcers 37%, GI 37%, dyspnea 20%) 48 pts dx during repro ys - 73% never discuss contraception, 30% didn't reach family plan 22 pt - 43 pregn, 33 birth: C-sxn, low bth wt @Rheumnow https://t.co/JRkyCVEXLB

More than 25,000 #ACR22 tweets since November 1 - keep going strong today and we will reach 100,000,000 impressions. Congrats to @rheum_cat, @RheumNow and @CreakyJoints for having the most impact with over 10M impressions each. @ACRheum @StevenEchard https://t.co/K2Kr4sAicS

Sarilumab (SAR) + 14 wk GC taper demonstrated significant efficacy vs the comparator arm in steroid refractory PMR patients and improvement in quality of life. Sustained remission was 28.3% SAR vs 10.3% comparator arm. Spiera R Abs#1676 https://t.co/gXGJzbYLHK #ACR22 @RheumNow https://t.co/oZBsRtxMUw

• Sarilumab in Patients with Relapsing Polymyalgia Rheumatica: A Phase 3, Multice…

Very interesting Thieves Market case... which I have also seen! Don't forget mycoplasma pneumoniae-induced rash and mucositis (MIRM) when patients presen tw/oral ulceration My patient had +ANA and carried a dx of PFAPA; only responded to abx! #ACR22 @RheumNow ABSTR#TMO2 https://t.co/B9dBkZyrlN

L05 #ACR22 High-dose Denosumab in Erosive Hand OA 48Wk, Double-blind PBO Phase 2 100 patients GUSS change higher in DEN v PBO at w24, incr at w48 New erosions lower in DEN w48 (2% v 7%, OR 0.23, p<0.001) Open label extension w improvement to baseline @RheumNow https://t.co/X6MF9q2bKj

Walrabenstein et al. RCT of 16-week triple intervention - plant-based diet, exercise, stress management - vs usual care in OA. It works, but we don't know which component, or if Hawthorn effect @RheumNow #ACR22 Abstr#1644 https://t.co/p74Ptd8bZ2 https://t.co/EOg7RxRmO7

• Effect of a Lifestyle Program Based on a Whole Food Plant-based Diet, Physical …

#ACR22 #Osteoporosis Guidelines Case Example: The FRAX score needs to be adjusted (multiply by 1.15 or 1.2) in pts who are expected to have cumulative dose >5 grams/year of steroids @rheumnow https://t.co/wF8LP0iZjw

#ACR22 #GIO #Osteoporosis Guidelines Case: "Young skeletons recover bone loss rapidly after GC are discontinued." In these pts, despite daily pred 10 mg/day, they just needs Ca/Vit D, lifestyle mod, and monitoring. @rheumnow https://t.co/a5DVZoB3l8

Reproductive concerns of adolescent patients with rheumatic disease Abstract #129 #ACR22 @RheumNow 🤰Worried about effects of dx and meds on fertility and pregnancy 💊Concerns about which birth control to use 🩸Effects of dx. on menstruation

14M111 Updated ACR Guidelines for Glucocorticoid-Induced Osteoporosis #ACR22 🦴🦴 Reminder: Recalculate FRAX scores with scaling for prednisone equivalent dosing! Use other clinical fracture risk assessments @RheumNow https://t.co/qZDlb1Cij7

L09 #ACR22 MTX in Post-Roe Era 6% patients reported barrier to MTX access 1 pt noted restriction to HCQ Most delays due to pharmacy - told due to pregnancy/abortion concerns or unexplained reason Rare BUT Real Problem - shows importance of @ACRheumDC advocacy efforts @RheumNow https://t.co/8Yr7nynzN6