Joerns et al. Baseline IL-17 higher in RD-ILD vs IPF. Low IL-13 assoc shorter progression free survival HR 17.36 @RheumNow #ACR22 Abstr#1109 https://t.co/I8R3SrxNfV https://t.co/he1A3SYDp0

• High Interleukin-13 Level Is Associated with Disease Stability in Interstitial …

Does curcumin help maintain drug-free remission RA? Answer is No Single center RCT Curcumin vs PBO w/ MTX withdrawal = flare-free survival = median time to flare (219 d vs. 214 d) Serum curcuminoid levels not asso w/ flares https://t.co/3U6W0Iuqrq Abs#1587 #ACR22 @Rheumnow https://t.co/GwAsY7OKTX

• http://bit.ly/3URYakx

TOFA and MTX: which one to withdraw first? RCT in 100+ RA pts in remission after 1 yr, 1 yr follow-up Withdraw MTX grp: Remission 30% LDA 40% Withdraw TOFA grp: Remission 50% LDA 65% diff NS small sample 8 SAEs, 72% recovery https://t.co/tMnet32TWF Abs#1586 #ACR22 @Rheumnow https://t.co/PWnkWYdlGk

• Sustained Remission Following the Discontinuation of Tofacitinib in Patients wi…

What to do next? Dazodalibep Rx in bDMARDs IR #RA pts. Dazo is a novel CD40 ligand antagonist Phase II RCT. N=78, multi dose phase II RCT. All doses improved DAS28. Dosing interval may be prolonged over time. Awaiting phase 3. Abst#2008 #ACR22 @RheumNow https://t.co/IrzflycKZp

⬆️ serum anti-CCP3 Ab, absence IA 👉 StopRA trial - ironically stopped🛑 ❌ hydroxychloroquine not superior to PBO in preventing/ delaying IA 👉rate of conversion to RA in CCP3+ve ~35% @ 3yrs #ACR22 @RheumNow Abst#1604

Juge @Juge_P_A @PhilippeDieude et al Excess of rare variants in JAK-STAT genes in RA-ILD vs RA 57% vs 46%;OR=1.37 95%CI[1.12-1.69]. Elucidates pathophysiology but also possible treatment rationale @RheumNow #ACR22 Abstr#1123 https://t.co/TAA0rODSmV https://t.co/2TjSY4CXDL

• Excess of Rare Deleterious Variants Within JAK-STAT Pathway - Related Genes in …

#Abs1260 #acr22 @rheumnow #acrbest Clincial&US eval 54 RA &18 PsA pts: Tenderness aasoctd w/radiographic progress in non-swollen jnts in PsA but not in RA. In tender non-swollen jnts in RA pts, baseline erosions& sonographic synovitis had significant impact on radio progression https://t.co/iqWvHiDeq8

Uggh! What would you do if your pt gets pregnant while on MTX & loses her baby, are you liable for accidental abortion? Should you advise termination if a pregnant pt’s health is deteriorating? @GreerDonley (#law professor) on theoretical risks #ACR22 @rheumnow https://t.co/L4FBWcKZnE