Interesting data on TNFi use in ankylosing spondylitis. Early TNFi use, compared to no TNFi associated with higher CVD, stroke and MACE. @rheum_cat any thought on why? and why there were so many non-TNFi users (15k vs. 2k)? Abs#0415 @RheumNow #ACR22 https://t.co/PVkt8gPHFW

@rheum_cat et al Abs 0415 TNFi initiation early in AS dz course (compared to no initiation) showed higher risk of incident CVD, stroke & MACE individually! Residual confounding by indication cannot be excluded. Were TNFi tx pts sicker? #ACR22 @RheumNow https://t.co/ERoDhS2yOY https://t.co/8tto5AIUSP

• The Association of Early TNF Inhibitor Use with Incident Cardiovascular Events …

Another study showing treatment withdrawal does not work. Golimumab withdrawal in nr-axSpA is inferior to continued treatment or tapered treatment, leading to more disease flares. Abs#0545 @RheumNow #ACR22 https://t.co/CBRnVdxXVo

2022 ASAS-EULAR Recommendations of AxSpA management 1) NSAIDs still first line 2) Analgesics/opioids contraindicated 3) TNFi, IL-17i first line bDMARDs, followed by JAKinibs 4) Tapering but not discontinuation of bDMARDs in sustained remission Abs#0542 @RheumNow #ACR22 https://t.co/ffaN2fMc3v

Liew @rheum_cat et al. No evidence of cardioprotective effect of early initiation of TNFi in AxSpA. In fact seemed to be associated higher risk! CVD (HR 1.17), stroke (HR 1.24), and MACE (HR 1.22) @rheumnow #ACR22 Abstr#0415 https://t.co/a9lpxQuMB9 https://t.co/GdGfYxcAH6

• The Association of Early TNF Inhibitor Use with Incident Cardiovascular Events …

Therapies for AS and nr-AxSpA are coming together. Both AS and nr-AxSpA present with similar burden of disease. TNFi, IL-17i and JAKi now approved for use in nr-AxSpA. Jose U Scher, SpA Review @RheumNow #ACR22 https://t.co/vcHcd7OyAU

England et al. Influence of FVC on choice of b/tsDMARD in RA-ILD. FVC predicts hospitalisation and mortality. However, it did not appear to influence choice of b/tsDMARD. Overall 67% of RA-ILD patients initiated TNFi, weird! @rheumnow #ACR22 Abstr#245 https://t.co/swuNHv96WD https://t.co/vy5FUPnNjo

• Influence of Forced Vital Capacity Impairment on Treatment Selection and Outcom…