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Drug Safety

      Next Generation T-Cell Engager: The Future https://t.co/gcrfzV6MSJ via @YouTube

      @alhkim great to see you and hearing a

      Nouf Al hemmadi NoufAhmedAlham2

      3 months ago
      Next Generation T-Cell Engager: The Future https://t.co/gcrfzV6MSJ via @YouTube @alhkim great to see you and hearing all about new T cell Engager , feasibility and less toxicity. @RheumNow #ACR25
      #0851
      Urinary Tenascin C predicts kidney function loss in lupus nephritis
      170 AMP-LN patients: Tenascin C (from renal my

      Mrinalini Dey DrMiniDey

      3 months ago
      #0851 Urinary Tenascin C predicts kidney function loss in lupus nephritis 170 AMP-LN patients: Tenascin C (from renal myofibroblasts) was the top predictor of eGFR decline (HR 4.6) Proteomic 11-marker risk score (AUC 0.91) outperformed proteinuria for prognosis #ACR25 @RheumNow
      #0852 LEVI-04, a novel p75NTR-Fc fusion protein, significantly reduces MRI bone marrow lesions in knee #OA 🦵📉
      Phas

      Mrinalini Dey DrMiniDey

      3 months ago
      #0852 LEVI-04, a novel p75NTR-Fc fusion protein, significantly reduces MRI bone marrow lesions in knee #OA 🦵📉 Phase II RCT (n=518): dose-dependent BML reduction (p<0.001) + correlated improvement in pain & function. Promising structure-modifying OA therapy @RheumNow #ACR25 https://t.co/huA8OaFGSd
      #1614 Another SLR informing the 2025 EULAR recommendations for PMR & LVV 🧭

      Fast-track clinics cut blindness &amp

      Mrinalini Dey DrMiniDey

      3 months ago
      #1614 Another SLR informing the 2025 EULAR recommendations for PMR & LVV 🧭 Fast-track clinics cut blindness & diagnostic delays; multimodal imaging pathways outperform biopsy alone. Key data shaping future referral & diagnosis guidance. @RheumNow #ACR25
      Key slide and takeaways on the ACR 2025 extrarenal SLE guideline. Presented by Lisa Sammaritano @RheumNow #ACR25 #ACRBes

      Antoni Chan MD (Prof) synovialjoints

      3 months ago
      Key slide and takeaways on the ACR 2025 extrarenal SLE guideline. Presented by Lisa Sammaritano @RheumNow #ACR25 #ACRBest https://t.co/Xa97O6RdBY
      As the population ages globally, rheumatologists are caring for an increasingly older patient population more than ever before. In RA alone, nearly 40 percent of patients are now aged 65 years or older. Yet the evidence guiding our treatment decisions continues to come from studies that rarely include them, giving rise to a fundamental question: do we really know how best to treat older adults with rheumatic diseases?
      #ACR25 Abstr#0773 Anti-MDA5 ab is assoc. with progressive DM-ILD. But MDA5 expression is also upregulated in IPF. Any ne

      Md Yuzaiful Md Yusof Yuz6Yusof

      3 months ago
      #ACR25 Abstr#0773 Anti-MDA5 ab is assoc. with progressive DM-ILD. But MDA5 expression is also upregulated in IPF. Any new biomarker which can link these ILD? Measuring reactivity to MDA5 (aa 201-300) epitope peptide may help identify poor ILD prognostics (with/out DM) @RheumNow https://t.co/rziwihKfIr
      Is tocilizumab equally effective in ischemic vs. non-ischemic GCA?

      Ischemic = vision, jaw claudication, or CVA

      Remissi

      Brian Jaros, MD Dr_Brian_MD

      3 months ago
      Is tocilizumab equally effective in ischemic vs. non-ischemic GCA? Ischemic = vision, jaw claudication, or CVA Remission at 6 mo higher in non-ischemic group then with equalization at month 12 No major difference in GCs at month 12 @RheumNow #ACR25 #Abst0739 https://t.co/OeYggSQYx8
      We need more biomarkers in GCA - what about fibrinogen?

      Miller et al retrospectively compared CRP, ESR, and fibrinogen

      Brian Jaros, MD Dr_Brian_MD

      3 months ago
      We need more biomarkers in GCA - what about fibrinogen? Miller et al retrospectively compared CRP, ESR, and fibrinogen at different points in GCA dx Fibrinogen (and ESR/CRP) only helpful prior to initiation GC with comparable performance @RheumNow #ACR25 Abst #0750 https://t.co/q5gFxDMnTy
      Abstract 0842
      💡 Urinary biomarkers as the next frontier for monitoring lupus nephritis activity
      🔹 Proteinuria didn

      Akhil Sood MD, MS AkhilSoodMD

      3 months ago
      Abstract 0842 💡 Urinary biomarkers as the next frontier for monitoring lupus nephritis activity 🔹 Proteinuria didn’t track w/ histologic activity 🔹 IL-16 & sCD163 correlated at baseline only 🔹 Urinary Tenascin C & BAFF correlated w/ activity at 1 yr @RheumNow #ACR25
      2 year extension data from SELECT-GCA:

      Patients in remission who remained on upadacitinib 15mg daily after 1 year had 9

      Brian Jaros, MD Dr_Brian_MD

      3 months ago
      2 year extension data from SELECT-GCA: Patients in remission who remained on upadacitinib 15mg daily after 1 year had 90% reduced risk of flare compared to those who switched to placebo Higher rates zoster, CK elevation in UPA group #ACR25 @RheumNow #ACRBest https://t.co/jf8Dh2wCBj
      Could a sputum test predict risk for RA conversion in at-risk patients?

      98 at risk pts, Converters had higher

      -BL sput

      Aurelie Najm AurelieRheumo

      3 months ago
      Could a sputum test predict risk for RA conversion in at-risk patients? 98 at risk pts, Converters had higher -BL sputum CCP levels -BL Sputum nucleosome and cit-nucleosome levels !although not asso after adjusting for sputum anti-CCP-IgA level In converters, correlation of https://t.co/bqmQqS1Jz5
      More biomarkers predictive of conversion to clinical RA in at-risk pts

      Serum PAD4 & PAD 4 levels measured in CCP+ a

      Aurelie Najm AurelieRheumo

      3 months ago
      More biomarkers predictive of conversion to clinical RA in at-risk pts Serum PAD4 & PAD 4 levels measured in CCP+ at-risk individuals -PAD4 (not PAD2) increased in RA Converters vs. non converters and HC -PAD4 levels Pre-RA = RA Within high CCP+ at risk individuals, higher https://t.co/LU5zUzui1G
      CMV is a worry with high-dose steroids, especially in certain settings.

      The risk is far from universal, though: in this

      David Liew drdavidliew

      3 months ago
      CMV is a worry with high-dose steroids, especially in certain settings. The risk is far from universal, though: in this Korean cohort treated with high dose pred, almost no-one without risk factors got it. Meds are rarely the only infection risk factor #ACR25 ABST203 @RheumNow https://t.co/zLYhLVKgYL
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