RESET-RA, RCT of vagus nerve stim (device that zaps pts in neck) Marginal improvements in ACR20 at wk 12; trend in to improvement in unblinded part of study fwiw Have never seen result that is more likely to be driven by plbo effect & unblinding 🤪 @RheumNow #ACR25 Abstr#2278 https://t.co/BlR570nv7k

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MSK side effects of CAR-T, based on FAERS pharmacovigilance data (also see @DrGomezPuerta in @seminarthrheum https://t.co/LnwjU5aebs) #ACR25 ABST1731 @RheumNow https://t.co/kREEy3HLE9

• https://www.sciencedirect.com/science/article/abs/pii/S0049017224002506
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PLEX continues to be OUT for DAH in AAV Retrospective review of ~1.4k AAV-DAH pt 375 who received PLEX compared to those who did not PLEX tx patients: - higher odds of death - higher sepsis - increased LOS - increased hospitalization cost @RheumNow #ACR25 Abst 2517

Mateo Faxas et al. TriNetX study, propensity score matched. 3000 patients. Arrythmia risk is higher with IL-6i vs TNFi in diabetic RA patients. V Tachy (HR 1.4), PPM need (HR 1.4) significantly higher. AF, SVT, VF all numerically increased. @RheumNow #ACR25 Abstr#2283 https://t.co/U2Tk38Mobg

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Molina et al. 52 weeks of MANHATTAN study. Guselkumab vs second TNFi after failure 1st TNFi in PsA. MDA 52% vs 33%. Remission/LDA 67% vs 62%. @RheumNow #ACR25 Abstr#2373 https://t.co/qdtOlKLfNU

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CD19 counts during RTX maintenance therapy do NOT perform well in assessing the risk of relapse Interestingly, only younger age was associated with relapse in this retrospective study @RheumNow #ACR25 Abst 1766 https://t.co/crsFKJ0LnP

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Can AI predict who stops their RA meds? In older adults on b/tsDMARDs, interpretable ML found frailty, comorbidity & age top the list for nonadherence risk. @RheumNow #ACR25 Abstract#2287

Girolami et al. VA study. Safety of DMARDs in RA following melanoma. 644 patients. 3 year all cause mortality. No significant difference, but graph sure looks like b/tsDMARDs are better. No melanoma specific mortality/recurrence data however. @RheumNow #ACR25 Abstr#2237 #ACRBest https://t.co/IN4LDkioT7

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Is RA-ILD associated with/ higher risk of infection? Retrospective US cohort study 151 RA-ILD 980 matched controls 79% higher risk of any and pulmonary infections in RA-ILD Pathogen type: bacterial, viral and fungi Some of these infections are preventable! Take Home: https://t.co/fPmRjLL7Po

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In DISCOVER-2, male PsA patients had greater radiographic progression than females despite similar baseline scores. Early joint response (W8 cDAPSA LDA) was linked to less progression more strongly in men. Highlights the sex differences in PsA outcomes. Abstract#2345 @RheumNow https://t.co/zIo59FYPVg

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Does specific ANCA subtype inform infectious risk? Retrospective review of 270 AAV patients revealed that about 1/3 pt developed severe infections... of these: - 64.1% MPO+ - 35.9% PR3+ Most infx during year 1 of tx No difference between CYC vs. RTX @RheumNow #ACR25 abst 2510

Simulation modeling by Patel et al helps generate probability of remission, relapse, and adverse events in newly dx AAV Projected risk by model were similar to observed rates in RCTs @RheumNow #ACR25 Abst 1764 https://t.co/xevkJ2Ih0M

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HCQ weight-based dosing: out HCQ whole blood monitoring: in Whole blood levels more precisely balance risks of SLE flare (under-dosing) vs. toxicitiy (over-dosing) Many pt on <5 mg/kg had supra-therapeutic blood levels with risk for toxicity @RheumNow #ACR25 #ACRBest Abst 1722 https://t.co/qIbACxAW39

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