Friday, 17 Nov 2017

Today's Headlines

J&J Hit with a $247 Million Verdict over Metal-on-Metal Hip Replacements

Reuters reports that a federal jury has ordered Johnson & Johnson and its DePuy Orthopaedics division to pay $247 million settlment to six patients who suffered from its defective Pinnacle, metal-on-metal, hip implants. in the US. J&J says it will  appeal this decision.

These implants were associated with tissue necrosis, bone erosion and other injuries due to implant design.

Stroke Increased in Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a chronic, inflammatory disease with systemic effects beyond the joints. While RA patients are known to have signficantly higher risks for cardiovascular disease and venous thromboembolic events, an association with stroke (CVA) is unclear.

A study claims data from Israel analyzed 11,782 RA patients and 57,973 age- and gender-matched controls.

DEA Cracks Down on Illicit Fentanyl

Reuters reports that  U.S. Drug Enforcement Administration (DEA) has declaed it would classify illicit versions of fentanyl at the same level as heroin, allowing criminal prosecution of anyone who possesses, distributes or manufactures illicit versions of the drug.

Good News from ACR17 - Gout

The following is a collection of gout-specific mentions culled from RheumNow's coverage of the Annual ACR 2017 meeting in San Diego.

Thiopurines and Anti-TNF drugs in IBD Associated with Increased Lymphoma Risk

JAMA presents a French report on the cancer risk of thiopurine or tumor necrosis factor inhibitor (TNFi) use in adult patients with inflammatory bowel disease (IBD) and finds a raised risk for lymphoma in IBD compared to those not treated with these agents.  (Citation source https://buff.ly/2z04f9h)

MTX Doubles Hepatotoxicity Risk in Psoriasis Patients

A study from the University of Pennsylvania Perelman School of Medicine was published in the Journal of Investigative Dermatology showing that the risk of incident liver disease doubled when patients with psoriasis (PsO) or psoriatic arthritis (PsA) take methotrexate (MTX), but not when MTX is used in rheumatoid arthritis. (Citation source https://buff.ly/2i9qizC)

BLOG

The quality of the meeting was on par with the host city, with extensive data presented on a range of topics, from social media to drug safety. The organization committee did a great job and I got the feeling that most people felt the congress was user friendly given the magnitude of the event. During this year’s meeting, I had the privilege of working with the RheumNow team, which gave me the opportunity to hone my social media skills and get my Twitter game on. After reviewing plenty of posters and going to numerous presentations, here are my top take home messages as classified by disease state.

Last month, a momentous occurrence took place in Cleveland: after 35 years, the enoteca and restaurant, Primo Vino, closed its doors to make way for an exciting development in Cleveland’s Little Italy. Allow me to make the rheumatology connection. 

I recently had a follow up with an SLE patient who wanted to discuss sun protection options since moving to Dallas, where we have 232 days of sunshine yearly. Sun protection is important for our patients. As rheumatologists, we have an obligation to go beyond 'avoid the sun or wear sunscreen when you're out' platitudes.

The antiphospholipid syndrome (APS) is a common disorder affecting patients with and without autoimmune disease. Despite wider recognition of APS among physicians as well as the expanding research collaborations, many clinical questions are still encountered in clinical practice, which require further evidence-based studies. In this “Across the Table” edition, Drs. Cush and Erkan discuss some of these APS-related questions. Our guest expert, Dr. Doruk Erkan offers up his approach to diagnosis and management of APS.

A new patient came in today; he noted that he made an appointment with me after reading a favorab

Dr. Philip Mease: Risankizumab in Psoriatic Arthritis (Abstract 2L)
Dr. Philip Mease discusses a late-breaking abstract on risankizumabin in psoriatic arthritis at the ACR/ARHP Annual Meeting in San Diego.
/vef/load/6934380e7ad6a6101dc7419bf9367ceb?width=640&height=365

Social

Daily Download

How Rheumatologists Diagnose and Treat RA