Friday, 22 Jun 2018

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Today's Headlines

Abatacept Misses in Lupus Nephritis

Dr. Richard Furie, MD, of Northwell Health in New York, presented the findings ofa large phase III trial of abatacept (Orencia) in lupus nephritis showing the agent failed to achieve a complete renal response.

Data presented at EULAR 2018 showed that at one year, a total of 35.1% of patients receiving abatacept achieved complete renal response, as did 33.5% of those randomized to placebo (P=0.73). 

Cosentyx Gets Radiographic Protection Indication for Psoriatic Arthritis

Novartis announced today that the US Food and Drug Administration (FDA) approved the inclusion of new evidence that Cosentyx® (secukinumab) significantly slows the progression of joint structural damage at Week 24 versus placebo in those with active psoriatic arthritis (PsA).

NSAID Use Around Conception Increases Miscarriage Risk

A study from the American Journal of Obstetrics & Gynecology analyzed pregnant women from the Kaiser Permanente healthcare system and compared newly pregnant women who took non-steroidal anti-inflammatory drugs or acetaminophen or neither showed that using NSAIDs around conception carried a more than four-fold higher risk of early miscarriage. (Citation source: http://bit.ly/2tqNWN6)

The Stress - Autoimmune Disease Connection

"Can stresss be the cause of my autoimmune disease?" is an often launched question met with shrugs of uncertainty or strongly held beliefs rooted in bias moreso than fact.

Swedish investigators have analyzed a large registry cohort and shown that exposure to stress-related disorders yields a significantly increased risk of autoimmune disease. They analyzed 106,464 patients with stress-related disorders, with 126,652 full siblings, and over a million non-stressed matched controls to assess a future risk of autoimmune disease.

Seronegative and Seropositive Rheumatoids Respond Equally Well

A cohort study of 241 DMARD-naive rheumatoid arthritis (RA) patients, meeting either 1987 ACR or the 2010 ACR/EULAR  classification criteria for RA, compared the baseline status and long term outcomes of seronegative (SNRA) and seropositive (SPRA).

CDC Obesity Prevalence Higher in the Rural USA

MMWR reports that approximately 46 million persons (14%) in the United States live in nonmetropolitan counties, where there is a higher prevalence of obesity-associated chronic diseases such as diabetes, coronary heart disease, and arthritis. (Citation source: http://bit.ly/2lj5yql)

BLOG

Good News!  Your research submission has been accepted for presentation at a national congress (i.e., ACR or EULAR).  This is often a first step in the lifetime of a project – Abstract, Presentation, Full Write-up and Publication.  Instead of being enthralled or overwhelmed with the notion of doing your first abstract, review my approach to creating, presenting and reviewing abstracts for a major medical meeting.

Leadership positions in medicine are disproportionately filled by men. Although the enrollment of medical schools are equal male: female or even some have more women, 40% of American medical institutions lack programs for recruiting women, or for retention and promotion of female faculty.

This may also be true in rheumatology, which is now attracting more women than men as trainees. I recently wrote an article in the Lancet about mentoring women in medicine and suggested ideas for improving the gender gap in leadership.  

Just because it’s busted, it doesn’t mean you have to fix it.  At some point, it’s important to know when to leave “good-enough” alone. Such is the story of the "busted valise" and what to do about it.

Three years ago we published our first edition of RheumNow. We have something - and someone - to celebrate. Surprise, Dr. Jack Cush - this one’s for you! 

Everyone wonders how he does it. Vision. Drive. Determination. Unwavering resolve. Strength of purpose. Commitment - day in, day out. Willing to take risks. Unwilling to settle. All these, yes, but also this: passion, heart and soul.

In celebration, we asked a few of his colleagues to share their remarks about this important milestone. Without further ado…

The introduction of a guest or speaker should be simple, functional and respectful. In the least, it should go something like, “I have the honor of introducing our speaker, Dr. John Brown, who comes to us from Brown University, where he is the Chief of Internal Medicine. Today he’s going to lecture on “the right way to lecture”. 

However, no one does this. Instead most try to do more, usually with knowledge gaps, and end up delivering incomplete, awkward or bad introductions.   

Introductions tend to either be awkward or great.  

Dr. Philip Robinson at EULAR2018 on Gout Studies I
Dr. Philip Robinson discusses several gout-related abstracts presented at the EULAR 2018 meeting in Amsterdam.
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How to Make an ACR/EULAR Poster