Univ Toronto lupus clinic study of 165 #SLE pts w/ Bx-proven LN (age 35.3 yrs; Dz dur 6.2 years). Half on antimalarial Rx. Being on HCQ did not alter Renal Bx outcomes (prolif GN, NIH AI, NIH CI, IFTA score. (But is known to improve renal outcomes) https://t.co/oQ0CgK7rXm https://t.co/PZX31wOPmL

Can DMARD Doses Be Safely Reduced for RA Patients? Close to 90% of patients with rheumatoid arthritis (RA) well controlled on targeted therapies were able to take 50% dosage reductions without experiencing worsened disease activity in a randomized trial, South Korean https://t.co/MyjZdRaGb4

In early RA, initial b/tsDMARDs are better than MTX. Metanalysis of 29 RCTs (13387 pts), Vs MTX alone, initial b/tsDMARDs + MTX signif incr DAS28 remission 2 6 mos (RR 1.62) & 12 mos (RR 1.54). Benefits greater w/ higher baseline Dz, seropositivity https://t.co/exwVOc08xR https://t.co/00UXGTGPaH

Kenneth G. Saag, M.D., https://t.co/TJOX58X5d5., Named North American Editor-in-Chief of Osteoporosis International; Dr. Saag also will oversee Archives of Osteoporosis in collaboration with the International Osteoporosis Foundation (IOF). Ken is a professor of medicine and https://t.co/KouJoStW5C

Colchicine & Statins: A significant interaction? Colchicine is frequently used in rheumatologic practice. Current ACR guidelines for gout management support anti-inflammatory prophylaxis, including colchicine, during initiation and uptitration of urate-lowering therapy https://t.co/eyDbfpQajN

Surgery for 1st MTP Osteoarthritis Hallux rigidus, or osteoarthritis of the first metatarsophalangeal joint (MTPJ), is common, but treatment options and long-term outcomes remain poorly understood. A 12-month clinical trial showed that first MTPJ arthrodesis (compared to https://t.co/fHda4GK4vA

Single center study of Probiotics in #PsA showed no benefit. 66 moderately active PsA pts (PASDAS>3.2) on stable Tx: Rx probiotic vs PBO x 12 wks. 56 pts analyzed, PASDAS <3 responders: 43% probiotic vs 65% PBO (P 0.167), w/ no change in gut permeability markers or stool https://t.co/g6icpjuQOU

UK survey study of 6607 autoimmune dz pts (91% female) saw females had longer Dx delays, more HCP visits, & signif more often told their Dz attributed to psychiatric (43% vs 33%: OR 1.56) or psychosomatic causes (34% vs 21%; OR 1.87). Females had slightly more misdiagnoses (48% https://t.co/tGhiWCSPy9

Study of Prognostic Nutritional Index (PNI) in 984 RA pts shows PNI is independently inversely corelated w/ RA dz activity, esp. PNI <45. PNI = ser albumin & lymphocyte count calculation (10 × s albumin [g/dL]) + (0.005 × lymphocyte count/mm³]). Other studies have shown modest https://t.co/AV3AGXwSfg

French National Health System study of 214,892 #RA pts (~40K on TNFi) found 562 demyelinating events (2008-2023) w/ cumulative 10 yr incidence of 0.32% w/ csDMARDs & 0.50% w/ TNFi (HR 1.47;1.11-1.95). Demyelinating events are rare in RA, but signif higher w/ TNFi https://t.co/6vUy5nsQ27

Washington Univ Medical School has recv $17 million from Advanced Research Projects Agency for Health to develop an intraarticular therapy using nanoparticles designed to regenerate osteoarthritis damage without any surgical intervention. https://t.co/hl5i3welwS https://t.co/M7LwbIYI88

92 early (<2 yrs) systemic sclerosis pts were treated with #MTX; 79% diffuse SSc. At 3 mos, 34% of dcSSc ≥25% reduction in mRSS - increasing to 612% a@ 24 mos (29% at 24 mos ITT w/ non-responder imputation). GC did not improve skin. Dz progression seen w/ 75% of MTX monoTx D/C https://t.co/WvqyI8GKjT

Prescribing New GLP-1-Based Therapies https://t.co/naNfd7B1zA https://t.co/WIi9ZIMH2l

How well do you know the week's news in rheumatology? RheumIQ Emails are becoming opt-in only Get the quiz by email Log in to receive each new case-based quiz directly in your inbox. https://t.co/i04scCX31o https://t.co/vV88xXfQ6W