Chinese cohort of 209 AOSD pts identifed 49 (23%) w/ lung dz (by CXR), yet 69% were asymptomatic. Significcant risk factors for AOSD-LD were pleuritis, MAS (HR 2.62), & Dz relapse (HR 2.6). Imaging patterns: acute exudative pattern most prevalent, followed by interstitial and https://t.co/2IPJWRJicP

The Hidden Cost of Gout For many people, gout is viewed as an episodic disease: a painful flare, a short course of treatment, and then life returns to normal. However, as rheumatologists, we know that recurrent attacks can lead to joint damage and tophi if left untreated. https://t.co/RWTp5KKkyw

Fibromyalgia: Diagnosis and Management https://t.co/L9nA1TlJKx https://t.co/G4bkxTsXCt

QD Clinic: Gout, Sepsis… or Both? Dr. Mrinalini Dey, London, discusses a complex case. https://t.co/UtncfZgZyL https://t.co/xVTA0LnPpN

The Lancet Rheumatology has a good editorial about the avacopan bad news reports with EMA, FDA and Japan issuing negative opinions that threaten the drugs future. Yet, since approval real world data on avacopan has been favorable w/ less steroid toxicity & most hepatotoxicity https://t.co/k6ebVeWv2K

SGLT2 inhibitors lower serum urate AND reduce gout flares — and may close the mortality gap (CV mortality benefit) and offer renal protection. For more gout content, follow our Gout: More than Flares campaign at https://t.co/lQoiFjubZJ, https://t.co/QywxaTSSv6

"Leeuwenhoek (invented the microscope) examined uric acid (C5H4N4O3) crystals from gout patients and found them to resemble needles. He expounded on his observations in an 11 July 1679 letter responding to an earlier query from Mr. Lambert van Velthuysen (1622–1685), a physician, https://t.co/mY2wqYlRda

Primary biliary cholangitis is a chronic cholestatic disease characterized by autoimmune-mediated destruction of bile ducts, leading to fibrosis, cirrhosis, & liver failure. Ursodeoxycholic acid is 1st line Rx. New Rx include elafibranor & seladelpar (activates peroxisome https://t.co/EYcleKlTIB

QD Clinic: Gout, Sepsis… or Both? Dr. Mrinalini Dey, London, discusses a complex case. https://t.co/UtncfZgZyL https://t.co/81SyzpWbcl

UK primary care database (2000–21) gout study of new colchicine initiators (n 31,478) vs noninitiators (mean 60 yrs, BMI 30), follow-up of 4.5 yrs. Colchicine use had a signif. 12% lower risk of Joint Arthroplasty (HR 0.88); 23% lower TJA in knee/hip OA (HR 0.77) https://t.co/TkYFYhANuH

QD Clinic: Gout: Is it the Journey or the Destination? Dr. Arthur Kavanaugh discusses a gout patient whose frequent flares improved after lifestyle changes, despite medication not being enough on its own. https://t.co/frf4O87L0I https://t.co/cjtiYY9Ayt