Tweets
I used to think #SSc #scleroderma pts w #SjD #Sjogren’s did better as more
Mild ‘#CREST’
Nope 👎
#CSRG study N>1000 pts
showed #SjD had
=#mRSS
But
⬆️#GI #gut issues
⬆️ #ILD ? From +#Ro
⬇️worse #QoL
#0231 #ACR26 @ACRheum @RheumNow https://t.co/A4zxpc24XN
Janet Pope @Janetbirdope ( View Tweet )
40 minutes 8 seconds ago
Rx of calcinosis in #SSc is ‘hard’
Small RCT of BID topical #sodium #metabiosulfite v #PBO
neg #trial but a trend to some imaging improvement at 4 mo
Tough trial to do
?need:
Larger, longer study
Higher dose?
Try sodium #thiosulfate instead
#0226
#ACR26 @ACRheum @RheumNow https://t.co/CyA1k4rnNr
Janet Pope @Janetbirdope ( View Tweet )
40 minutes 12 seconds ago
#dcSSc active
Early allogenic #CAR-T -initial dosing had #mRSS drop of 16pts (L Chung)
Well tolerated
in vivo #CAR-T #CD19 N=3 SSc + for #skin & #lung 🫁 from China
+ in SLE NEJM just published
closer to scalable Rx vs autologous!
#ACR26 @RheumNow @ACRheum
#0223, 0225
Janet Pope @Janetbirdope ( View Tweet )
40 minutes 14 seconds ago
Use deep B cell depletion in #diffuse #scleroderma if #rituximab fails?
🤞
Small case series from France showed #obinutuzimab seemed to be well tolerated and reduced #skin #score #mRSS post #RTX which was d/c for loss of effect or infusion rx’n
Need RCT
@RheumNow #0222 #ACR26 https://t.co/iEv2T4XcYS
Janet Pope @Janetbirdope ( View Tweet )
40 minutes 17 seconds ago
There's a LOT of talk about CAR-T safety in autoimmune disease, and whether it's worth the payoff.
In amongst all the moving parts, it's not so simple.
here's my breakdown of what zola-cel has taught us so far @RheumNow #ACR26
https://t.co/mGZmOsoE8o
David Liew @drdavidliew ( View Tweet )
1 hour 51 minutes ago
Ultra-processed food & RA: In 108,886 participants, highest vs lowest intake was associated with incident RA (HR 2.58), but the association lost significance after nutrient adjustment. Findings support a potential role of dietary quality in RA development @Rheumnow #0949 #ACR26
Mrinalini Dey @DrMiniDey ( View Tweet )
1 hour 51 minutes ago
In 64 RA patients randomized to ITIS or Mediterranean diets, both groups improved over 3 months, with distinct microbiome/metabolomic response patterns. Different dietary interventions achieve clinical benefit through complementary biological mechanisms. #0948 @Rheumnow #ACR26 https://t.co/Ls1awH3pgE
Mrinalini Dey @DrMiniDey ( View Tweet )
1 hour 51 minutes ago
Low-dose naltrexone fails again :(
LoDoNaVasc blinded crossover RCT of 60 pts with remission/very low vasculitis activity. No difference in PROMIS physical or mental health
Supports results from @TheLancetRheum in fibromyalgia
Sadly, this does not seem to work
@RheumNow https://t.co/S2XRSyGvIZ
Mike Putman @EBRheum ( View Tweet )
1 hour 51 minutes ago
Hellmich et al. Avacopan real world safety. Relatively reassuring, higher rate abnormal liver tests, one serious. Only 254 patients, and European study, so may miss the rare serious liver events mainly reported from Asia. @RheumNow #ACR26 Abstr#0931 https://t.co/KLyborCIWF
Richard Conway @RichardPAConway ( View Tweet )
1 hour 51 minutes ago
MTX hold 2 wk after each RZV dose: better T-cell response
RCT substudy, n=38, stable ARD
gE CD4 responders 65→95% hold vs 61→67% continue (p=0.038)
IL-2/TNF-α driven
Reasonable in stable pts. Wait for a bigger trial.
＠RheumNow #ACR26 Abstr#0899 https://t.co/4bobGIAuZX
Henrique Dalmolin @he67407 ( View Tweet )
1 hour 51 minutes ago
Does vaccine timing matter more than dose count?
#ACR26 Abstract 0901: In 918 rheumatic disease patients hospitalized with COVID-19, longer time since the last booster was linked to higher mortality (OR 1.97), unlike vaccination status or dose count.
@RheumNow #ACR26 https://t.co/dmmuBkycmd
Licia Mota @Mota_licia_reum ( View Tweet )
1 hour 51 minutes ago
RheumNow’s expanded coverage of the #ACR26 annual meeting is sponsored by Eli Lilly and Company.
All coverage content is independently selected by RheumNow and its faculty.
Dr. John Cush @RheumNow ( View Tweet )
2 hours 27 minutes ago
ACR 2026 RheumNow Day 1 Recap https://t.co/EvcoMDycEv
Links:
Dr. John Cush @RheumNow ( View Tweet )
2 hours 27 minutes ago
‘Strong’ data in #myositis
#0904 #Efgartigimod ⬇️Igs &#Abs
LB +ph3 #RCT -👍on Wed
#0905 #nipocalimab in #IIM also #FcRn
#0906 #ruxolitinib ⬆️#survival in severe #MDA5 - but not RCT
#0907 +RCT IIM #Brepocitinib
☑️clinical remission
☑️HAQ
☑️LDA
#ACR26 #ACRbest
@RheumNow
Janet Pope @Janetbirdope ( View Tweet )
4 hours 18 minutes ago
Kim et al. Target trial emulation. Add on pulse steroids (to RTX or CYC) in AAV. No benefit and higher infection risk. @RheumNow #ACR26 Abstr#0929 https://t.co/RPtIiP0XLN
Richard Conway @RichardPAConway ( View Tweet )
4 hours 18 minutes ago