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Why does obesity worsen Rheumatic disease?

Dr. John Cush @RheumNow ( View Tweet )

4 hours 31 minutes ago
Myositis patients with anti-TIFF-1 gamma antibody positivity are at risk for what? Answers: Calcinosis; Overlap syndrome; Progressive ILD; or Malignancy. See if you got it right in this week's RheumIQ at https://t.co/UaXqHKWizt.

Dr. John Cush @RheumNow ( View Tweet )

12 hours 46 minutes ago
True or False: In a Korean National Health Insurance study, gout patients on allopurinol had a significantly higher risk of fractures, with the highest risk seen in those with low adherence. Did you get it right? Take this week's RheumIQ and see: https://t.co/UaXqHKWizt. https://t.co/7nILMVUeGw
Dr. John Cush @RheumNow ( View Tweet )
14 hours 46 minutes ago
True or False: Jaccoud's arthropathy causes joint deformities due to bone and cartilage damage, and erosions are typically visible on X-ray. Test your knowledge in this week's RheumIQ at https://t.co/UaXqHKWizt.

Dr. John Cush @RheumNow ( View Tweet )

16 hours 16 minutes ago
NEJM images: Jaccoud’s arthropathy is a chronic, deforming;from laxity of the ligaments & tendons (not damage to bone & cartilage). Deformities are reducible & no erosions on Xray. Jaccoud’s mimics RA, but most seen w/ SLE. https://t.co/99WDNcpT5c https://t.co/EdiGW1dDWY
Dr. John Cush @RheumNow ( View Tweet )
1 day ago
Novartis & BMS CAR-T Cell Trials on Hold Reuters and the Wall Street Journal report that both Novartis and Bristol Myers Squibb (BMS) have paused their autoimmune disease CAR-T cell trials due to safety concerns, including deaths. https://t.co/ffcAHhtdBh https://t.co/zKlFcBdEod
Dr. John Cush @RheumNow ( View Tweet )
1 day 10 hours ago
Chinese retrospective study of 140 Bx proven Kikuchi-Fujimoto pts shows very few evolve into #SLE. While 60% were ANA+ (11.3% other autoAbs) - none developed SLE (median F/U 39mos). KFD is benign, self limiting necrotizing lymphadenitis usually in young women. https://t.co/NjNoMOgNcC
Dr. John Cush @RheumNow ( View Tweet )
1 day 12 hours ago
FDA Approves Brepocitinib to Treat Dermatomyositis The FDA and Priovant recently announced approval of brepocitinib (Lisraya), a JAK1/TYK2 inhibitor, for the indication of adults with dermatomyositis (DM). This is the first oral (once daily) agent approved for DM. https://t.co/blsl1365XS
Dr. John Cush @RheumNow ( View Tweet )
1 day 14 hours ago
NEW FROM EULAR: A real-world analysis of predictors of IBD in PsA. 🔎 In patients with PsA, signs and symptoms of IBD may appear before diagnosis, but do we know what to look for? Explore the poster: https://t.co/JX0Y0AQ07N Sponsored by AbbVie Medical Affairs + Health Impact. https://t.co/zx9kjsiZfZ
Dr. John Cush @RheumNow ( View Tweet )
1 day ago
Necrotizing arteritis is rare w/ IgA Vasculitis (IgAV). Review compared 30 IgAV-NA to 257 adult IgAV & 196 PAN pts. Overall IgAV-NA is a severe IgAV phenotype with life-threatening complications & should prompt vascular imaging and intensified immunosuppression. IgAV-NA had more https://t.co/GRVcqRPKTL
Dr. John Cush @RheumNow ( View Tweet )
2 days ago
Novartis & BMS CAR-T Cell Trials in autoimmune diseases are put on hold with concerns about safety and 3 deaths. https://t.co/ffcAHhtdBh https://t.co/aBCcaKGlF4
Dr. John Cush @RheumNow ( View Tweet )
2 days ago
Metanalysis looked at neutrophil to Lymph ration (NLR) in SLE - 31 studies, 4,006 SLE pts. NLR signif incr in SLE worldwide. NLR was higher in Active vs inactive SLE, and showed a significant but moderate correlation w/ SLEDAI (CC=0.354, p < 0.001). https://t.co/tA6UBb1wVo https://t.co/XoXrf6HlKL
Dr. John Cush @RheumNow ( View Tweet )
2 days 12 hours ago
Small series of 5 Idiopathic inflammatory myopathy (IIM) pts Rx w/ obinutuzumab for refractory myositis (2 antisynthetase syndr, 1 DM, 2 overlap myositis). 4/5 patients achieved complete response. Lung improved/stabilized in ILD patients. Two required second obinutuzumab cycle. https://t.co/ev9qlEO04l
Dr. John Cush @RheumNow ( View Tweet )
2 days ago
Ro52 Abs in idiopathic inflammatory myopathies (IIM). From 2,126 IIM China/Japan pts, Ro52 positivity was common (46%), esp in MDA5+ DM & anti-synthetase syndr (ASyS) & was assoc w/ high freq of ILD, rapidly progressive ILD, and poor prognosis. https://t.co/TA4gSnZax1 https://t.co/riYs5YJwQV
Dr. John Cush @RheumNow ( View Tweet )
2 days ago
QD Clinic: RA, IBD and Frank's sign Daric Mueller, PA-C, St. Clair Shores, MI, presents a case called, "Rheumatoid Arthritis, IBD and Frank's Sign", as part of RheumNow's "The Obesity Imperative" campaign presented in September 2026. https://t.co/XMD0b35fiu https://t.co/9WUdZKAR0w
Dr. John Cush @RheumNow ( View Tweet )
3 days ago
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