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FDA has issued new draft guidance on the "Use of Data Monitoring Committees in Clinical Trials", updating its 2006 guidance document. "..the DMC should have access to safety results as well as comparative efficacy results." https://t.co/F0vKOxCLq9 https://t.co/xBa4Q1ukqo https://t.co/KeBUsYIl6u
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Dr. John Cush RheumNow ( View Tweet)
FDA has issued new draft guidance on the "Use of Data Monitoring Committees in Clinical Trials", updating its 2006 guidance document. "..the DMC should have access to safety results as well as comparative efficacy results." https://t.co/F0vKOxCLq9 https://t.co/xBa4Q1ukqo https://t.co/KeBUsYIl6u
Dr. John Cush RheumNow ( View Tweet)
Sarcoid arthritis (SA) seen in 19% of sarcoid pts. Metanalsysis of 49 articles (8574 pts) found Ankles most frequent (80%) followed by knees & wrists. Monoarthritis was uncommon (1%). Acute , 0-2, I2 55%). Acute SA (oligo & poly) was linked to E nodosum. https://t.co/j5toHlmyoA https://t.co/oC1yxvFHRJ
Dr. John Cush RheumNow ( View Tweet)
In 551 juvenile myositis pts, 36% had myositis assoc Abs (MAA); 13% had >1 MAA. MAA+ pts had more overlap dz (18 vs 6%, p<.001) & assoc w/ Raynauds (OR 2.44), ILD (OR 3.43), chronic Dz (OR 1.72), mortality (OR 3.76). # MAAs was assoc w/ mortality (OR 1.83) https://t.co/BXhasmel3Z
Dr. John Cush RheumNow ( View Tweet)
Study of 43 SSc patients w/ gangrene shows Smoking Hx ; positive-ACA, ANCA, APL Abs & high ESR were independent risk factors for digital gangrenes in SSc. Vasculitis and macrovascular disease may contribute to the progression of digital gangrene https://t.co/3DY2Hx19s0 https://t.co/BfXANmckwF
Dr. John Cush RheumNow ( View Tweet)
Could Weight-Loss Drug Improve Hip Replacement Outcomes?
The antidiabetic/weight-loss drug semaglutide either does or does not help patients undergoing THA avoid complications and other poor outcomes, according to 2 retrospective studies presented here.
https://t.co/bB2E4T2aiI https://t.co/EWVcQ01GuL
Dr. John Cush RheumNow ( View Tweet)
Board question/clinical pearl alert: Hairy Kidney Sign is an important indicator of Erdheim-Chester. Dr. @anisha_dua #RWCS24 @RheumNow @RWCSmtg - abnormal histiocytes now classified as malignancy - bone pain common presenting complaint - can see aorta, pleura, pericardium… https://t.co/XO5GXSNJZk https://t.co/gBn8Hii7F0
Dr. Rachel Tate uptoTate ( View Tweet)
Retrospective study of non–small cell lung cancer(NSCLC) pts Rx w/ immune checkpoint inhibitor finds that those who develop immune-related AE (irAEs) (n=803) have improved overall survival (23.7 vs 9.8 mos survival; P < .001) https://t.co/yiwJZJU10W https://t.co/fwFFlf7Q6L
Dr. John Cush RheumNow ( View Tweet)
Catastrophic APL has high mortality.. Use of triple Rx w pulse steroids, IV heparin and plasma exchange still only has 50% survival. #RWCS24 https://t.co/ycttHcpmjL
Dr. John Cush RheumNow ( View Tweet)
NJ leads on prior authorization legislation:
- Prior auth turnaround time is 24 hrs urgent requests
- Peer-to-peers for denials involves same specialty MD
- Transparency: companies have to share data on denials/reasons.
(29 states w/ active bills/reforms) https://t.co/pZlyW68DDL https://t.co/uc251qj2Gf
Dr. John Cush RheumNow ( View Tweet)
Full read overview of SJOGRENS SYNDROME, which can be Primary SS or Secondary (15% in SLE, 20% RA, & 30% systemic sclerosis). SS Organ involvement:
- CNS 2-17%
- Renal <=10%
- ILD 10-20%
-MSK 45-56%
https://t.co/RElOFfP2xr https://t.co/aJI041VCuE
Dr. John Cush RheumNow ( View Tweet)
JAMA Clinical Challenge - Recurrent Fever, Rash, and Shortness of Breath in a 69-Year-Old. Admited with fever, fatigue, rash, right periorbital swelling, SOB, Palpable purpural, Serositis previously - whats your diagnosis? https://t.co/j6aSGffpPv https://t.co/du6pEo74xp
Dr. John Cush RheumNow ( View Tweet)
Leaving Academia
Dr. Jack Cush reviews the news and journal reports from the past week on https://t.co/V10S4oVFsv. This week we discuss hipsters undergoing hip replacement, pregnancy outcomes in RA and the future of academic clinicians.
https://t.co/cuENQxlSOt https://t.co/olMihVm4bU
Links:
Dr. John Cush RheumNow ( View Tweet)
Leaving Academia
Dr. Jack Cush reviews the news and journal reports from the past week on https://t.co/V10S4oVFsv. This week we discuss hipsters undergoing hip replacement, pregnancy outcomes in RA and the future of academic clinicians.
https://t.co/cuENQxlSOt https://t.co/olMihVm4bU
Dr. John Cush RheumNow ( View Tweet)
Telemedicine in MSK - systematic review of 35 studies (2015-22); 69% of low quality. Most found telemedicine to be equal or better by PROMs (vs F2F care). All showed notably lower costs for telemedicine compared to in-person visits. https://t.co/eA8QEzhJGZ https://t.co/h65WMDXjQN
Dr. John Cush RheumNow ( View Tweet)
Since April 2017, DEA Take Back (drugs) campaign has spread to 17,000 locations where your patients can safely dispose of narcotics or unsafe drugs. Find your Everyday Drop-Off center by clicking here: https://t.co/uZPtFtXk6a https://t.co/dRalITYyfV
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Dr. John Cush RheumNow ( View Tweet)
One-Third of Physicians Intend to Leave Academia
A cross-sectional survey of academic physicians shows that approximately one-third intend to leave their institutions in the next two years.
https://t.co/Bugkjg9r9q https://t.co/PjPJi8TICz
Dr. John Cush RheumNow ( View Tweet)
Outcomes of Acute, Subacute and Persistent Low Back Pain
Low back pain is a major cause of disability around the globe, with more than 570 million people affected.
https://t.co/aIR110aEr0 https://t.co/tKPp0Un68H
Dr. John Cush RheumNow ( View Tweet)
Diet and Osteoarthritis Pain
Knee osteoarthritis (OA) pain was worse with a pro-inflammatory diet, an observational study suggested.
https://t.co/GHSd9SzNav https://t.co/MiCj9gE4Kj
Dr. John Cush RheumNow ( View Tweet)
Dead Words Eulogy
This is a bonus lecture provided to RheumNow Live 2024 registrants, and being shared with our RheumNow audience. Today is the last day to register to attend virtually (or in person); go to https://t.co/fc9DGbVDJ5 for more information.
https://t.co/d4IbIbAIX8 https://t.co/egNtTNincb
Links:
Dr. John Cush RheumNow ( View Tweet)