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Dead Words Eulogy
This is a bonus lecture provided to RheumNow Live 2024 registrants, and being shared with our RheumNow audience. Today is the last day to register to attend virtually (or in person); go to https://t.co/fc9DGbVDJ5 for more information.
https://t.co/d4IbIbAIX8 https://t.co/egNtTNincb
Links:
Dr. John Cush RheumNow ( View Tweet)
A picture paints a thousand words. One of the reasons why statistical significance is not the be all and end all. I would say severe DAH is the most likely scenario I would use PLEX, more so than severe renal disease. @EBRheum @RheumNow #RNL2024 https://t.co/GHg6t4OHxf
Richard Conway RichardPAConway ( View Tweet)
Goodbye AS.
Eric Ruderman
#RNL2024
@RheumNow https://t.co/FThKwuP3M6
Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)
Very insightful talk on Vasculitis and pregnancy by Catherine Sims.
Pregnancy compatible medications.
Remission state.
Checking antibodies ; risk of transmission, pregnancy and fetal morbidity.
#RNL2024
@RheumNow https://t.co/81NAN1ulO5
Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)
Cancer and Myositis #RNL2024 @RheumNow
@DrLisaCS on Cancer screening:
Risk stratify: dermatomyositis, NXP2, TIFy, <40yo, refractory, dysphagia, cutaneous necrosis at higher risk
Enhanced risk stratification for those at risks, versus "basic screening" for lower risks https://t.co/3yy9Fx1pk8
Eric Dein ericdeinmd ( View Tweet)
Continue to love this myositis diagram. Seems to be getting ever more complicated though! @DrLisaCS @RheumNow #RNL2024 https://t.co/eXz6144y3y
Richard Conway RichardPAConway ( View Tweet)
Cancer and Myositis #RNL2024 @RheumNow
@DrLisaCS
Dermatomyositis risks - TIF1y is highest risk, followed by NXP2
Protective features: childhood onset, ILD, arthralgias
Cancer and myositis often present w/in 1 yr before or after
Cancer is major cause of death
Eric Dein ericdeinmd ( View Tweet)
Are we overprescribing because guidelines may be skewed to favor the pharmaceutical industry? Interesting questions posed by Dr. A Kavanaugh #RNL2024 @rheumnow https://t.co/wEwHaWNY5k
TheDaoIndex KDAO2011 ( View Tweet)
Dr. A Kavanaugh discussed Ethics #RNL2024: publication bias where positive results are likely to be published compared to those with no effects -- this is a sham study with made up data submitted to 2 different ortho journals. @rheumnow https://t.co/j6gVgA67nC
TheDaoIndex KDAO2011 ( View Tweet)
Kavanaugh on Medical Ethics
#RNL2024 @RheumNow
Bias in research for ++ outcomes leads to fudging/biased interpretations of results
Fabricated study results submitted to orthopedic journals:
- 97% acceptance for positive result, 80% for no-difference result. Bias towards +outcome https://t.co/x7JJabSs4z
Eric Dein ericdeinmd ( View Tweet)
Kavanaugh on Medical Ethics
#RNL2024 @RheumNow
How do we informed consent?
- How to fully inform pts in complex research?
- Or paternalistic to not provide detailed info
- How deep to disc risk/ben?
- Easier to study in countries w/o good SoC
Prior hx: prisoners, Nazi, Tuskegee
Eric Dein ericdeinmd ( View Tweet)
Dr P Seo answers audience questions…he does not check ANCA levels regularly as results do not impact his actions but may induce anxiety #Vasculitis #RNL2024 @RheumNow https://t.co/GV62DF7s3y
TheDaoIndex KDAO2011 ( View Tweet)
Dr. P Seo's summary slide on management of #vasculitis #RNL2024 @rheumnow https://t.co/cZLI6iz1sL
TheDaoIndex KDAO2011 ( View Tweet)
How Dr. P Seo manages #vasculitis patients with nonrespiratory manifestations #RNL2024 @rheumnow https://t.co/sjTXulDZ3a
TheDaoIndex KDAO2011 ( View Tweet)
EGPA - Peanut butter and Jelly
@philseo
Respiratory symptoms and systemic disease
Respiratory: non-systemic (inhalers, steroids, irrigation) IL-5 inhibs
Non-respiratory: eosinophilic (myocarditis, urticaria, EE), vasculitis (MM, GN, DAH, purpura, arthralgias)
#RNL2024 @RheumNow https://t.co/KTlvZ1cnfH
Eric Dein ericdeinmd ( View Tweet)
Dr. P Seo's Pearls for #Vasculitis:
1. Weekly or q2weeks SC TCZ is fine for newly diagnosed patients, but if pts relapse, use weekly TCZ.
2. oral steroids perform fine (no need to do IV pulse) even in pts with vision changes
3. taper steroids over 3-4 months
@rheumnow #RNL2024
TheDaoIndex KDAO2011 ( View Tweet)
The great unknown with tocilizumab in GCA, do you stop, how do you stop, etc. @philseo approach. I'm not as brave! Usually park at every other week dosing @RheumNow #RNL2024 https://t.co/y7mg57mWND
Richard Conway RichardPAConway ( View Tweet)
How I do it, treatment of CGA with Dr. @philseo, who thoughtfully paused so everyone could take a picture of this slide knowing full well it was already at our fingertips! Such a gentleman!
#RNL2024 @RheumNow https://t.co/8kqacqkRM6
Dr. Rachel Tate uptoTate ( View Tweet)
Dr @anisha_dua's takehome points for treating GPA in 2024
*RTX and CYC are both effective followed by RTX at least 500mg q 6 mo for at least 2 years
*PLEX not generally used, but may be effective in preventing ESKD
*Rapid GC tapering may not be suitable for all pts
*Avacopan is… https://t.co/haI19Sgpmu https://t.co/jhjXLwd0Uw
Dr. Rachel Tate uptoTate ( View Tweet)
Dr @anisha_dua's takehome points for treating GPA in 2024
*RTX and CYC are both effective followed by RTX at least 500mg q 6 mo for at least 2 years
*PLEX not generally used, but may be effective in preventing ESKD
*Rapid GC tapering may not be suitable for all pts
*Avacopan is… https://t.co/haI19Sgpmu https://t.co/jhjXLwd0Uw
Dr. Rachel Tate uptoTate ( View Tweet)