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The Week in Review: 5 February 2016

  1. Pregnancy in inflammatory arthritis patients (RA, IBD, PsA, AS): non-significant trend of congenital anomalies in those exposed to TNF inhibitors.
  2. Women with JIA as a Child: First birth analyses showed an increase in congenital anomalies.
  3. Early Rheumatoid arthritis patients: high incidence of comorbidities; over 5 yrs. 4% develop comorbidities.
  4. 14-3-3η: Examined in early inflammatory arthritis and high levels found to correlate with X-ray progression and not achieving remission.
  5. TNF inhibitors and risk of Skin Cancer: RA patients have higher rates of skin cancer, TNFi exposure does not increase risk of Basal cell but may be increased risk of squamous cell cancers.
  6. Giant cell arteritis: double the rates of serious infections in the first year – especially with increasing age or steroids.
  7. Pediatric lupus, acute pancreatitis and MAS: Pediatric lupus patients have a greater risk of acute pancreatitis (more so than adults). Pediatric Lupus with acute pancreatitis has a very high risk of MAS and death.
  8. Lupus and risk of adverse pregnancy outcomes: PROMISSE study shows that only the lupus anticoagulant (not APL or B2GP1 Abs) is associated with adverse pregnancy outcomes.
  9. Stat: 44 opioid overdose deaths per day in the USA.
The author has no conflicts of interest to disclose related to this subject
Dr. Cush is the Director of Clinical Rheumatology at the Baylor Research Institute and a Professor of Medicine and Rheumatology at Baylor University Medical Center in Dallas, TX. He a Professor of Clinical Medicine at the University of Texas Southwestern Medical School.
Dr. Cush is the Executive Editor of and also Co-Edits the online textbook 
Dr. Cush's research and interests include novel drug development, rheumatoid arthritis, spondyloarthritis, drug safety, pregnancy and Still's disease/autoinflammatory syndromes. He has published over 140 articles and 2 books in rheumatology.
He can be followed on twitter: @RheumNow.

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