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1 September 2017: The RheumNow Week in Review

The RheumNow Week in Review discusses the past week's news, journal articles and highlights from This week's report includes new data on IL-1 inhibition and protection from CV events and lung cancer, baricitinib given a reprieve, and features on infections - HBV, shingles and mortality of septic arthritis.

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  1. 25 studies shows low risk of HBV reactivation (1.6%) w/ resolved HBV - not changed by TNFi, other biologics, DMARDs  
  2. 1667 geriatric pts w/ Septic arthritis matched 1:10 w/o; those w/ Septic arthritis had 50-100% increase mortality
  3. RT @NYTHealth: FDA announces crackdown on "unscrupulous" stem cell clinics.
  4. Severe (ocular) Behcets study: ~half respond to TNF inhib but only half these stay in remission w/ TNFi withdrawal
  5. Epidemiology of SLE varied but incidence appears to be increasing. Highest frequencies in AA, N America (23/100K-PY); lowest in Africa, Ukraine, N. Australia
  6. Untreated Sleep apnea increases free fatty acids, glucose, cortisol and blood pressure during sleep.
  7. FDA approves 1st gene therapy - CAR T-cell therapy approved B-cell acute lymphoblastic leukemia
  8.  FDA Approves Genentech’s Actemra (tocilizumab) for the Treatment of CAR T Cell-Induced Cytokine Release Syndrome -
  9. Turnabout for Baricitinib  
  10. Another Adalimumab Biosimilar Approved 
  11. Canakinumab Reduces CV Outcomes in High Risk Patients  
  12. Canakinumab Patients have Lower Risk of Lung Cancer
  13. Shingles Vaccine Studies in A&R  
  14. Therapeutic Update:  See what Drs. Mease, Gibofsky, Cush have to say about FDA hearing on Tofacitinib for Psoriatic Arthritis 
  15. The job is not you, nor is your income, car or good looks. You are your principles and what you do when those principles are needed.  Listen to this podcast by Malcolm Gladwell



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