Friday, 14 Feb 2020

You are here

Alcohols Net Zero Effect in Rheumatoid Arthritis

A report from The National Databank for Rheumatic Disease addressed the impact of alcohol on disease activity and mortality in rheumatoid arthritis (RA) and found that alcohol use was not associated with changes in disease activity or mortality, after addressing confounders. 

It has been reported that alcohol use in RA is associated with lower disease activity (measured by the PAS) and better quality of life measures. But is this directly attributable to an antiinflammatory effect or might the association might be explained by reverse causality.

The NDB has 16,762 RA participants who were assessed for alcohol use, disease activity, and other outcomes.

They found that there was greater alcohol discontinuation and less alcohol initiation with greater disease activity, older age, female sex, nonwhite race, obesity, greater comorbidity, low quality of life, low educational level, low income, and work disability.

While alcohol users did have lower PAS‐II scores and a lower mortality (odds ratio 0.87), these associations were not seen in after adjusting for confounders.

Higher disease activity, disability, comorbidity, and poor quality of life contribute to overall reductions in alcohol use.

Active use alcohol use should not be promoted with the aim of reducing disease activity or mortality.

Disclosures: 
The author has no conflicts of interest to disclose related to this subject

Add new comment

More Like This

DMARD Inertia by Registry Rheumatologists

A registry study of metric use (primarily RAPID3 and CDAI) in the treatment of rheumatoid arthritis (RA) patients shows that, even in the face of moderate or high disease activity, treatment changes by rheumatologists were relatively low (35.6–54.6%).

Bariatric Weight Loss Fails to Alter RA Risk

Obesity has been shown to be a risk factor for the onset of rheumatoid arthritis (RA) and also shown to affect outcomes by impairing responses to many DMARD therapies. A Swiss study of RA patients undergoing bariatric surgery failed to show that bariatric surgery and weight loss had any effect on the incidence of RA.

Limited Advantage to Very Early vs. Delayed Etanercept in RA

The VEDERA study sought to confirm whether the very early introduction of first-line etanercept+methotrexate (ETN+MTX) was superior to treat-to-target MTX (MTX-TT) in patients with early RA.

RheumNow Podcast- 2019 EULAR RA Guidelines (1.31.20)

Dr. Jack Cush reviews the news and journal articles from the past week on RheumNow.com.

Rheumatoid Arthritis Antibodies Linked With COPD

Women who were seropositive for anti-citrullinated protein antibodies (ACPA) and ultimately went on to develop rheumatoid arthritis (RA) were also at increased risk for being diagnosed with chronic obstructive pulmonary disease (COPD), analysis of data from the Nurses' Health Study showed.