Friday, 13 Dec 2019

You are here

ANCA Levels Predict Relapse in ANCA-Associated Vasculitis

A team of Japanese investigators examine 126 patients with ANCA-associated renal vasculitis to see if ANCA levels would predict disease relapse.

With a median 41 months of observation, 118 patients achieved remission, and after remission, 34 patients relapsed (21.7%). The risk of relapse was significantly associated with lung involvement (adjusted HR 2.29) and increased ANCA levels (adjusted HR 17.4). The median time from ANCA level increase to relapse was 0.6 months (IQR 0–2.1 mos).

Hence, in this study an increase in ANCA level during remission was associated with a significant risk of disease relapse and may be useful in guiding treatment decisions in patients with ANCA-associated vasculitis.

The author has no conflicts of interest to disclose related to this subject

Add new comment

More Like This

CRP in SSc: Identifying a Severe Phenotype

Patients with systemic sclerosis (SSc) who have persistent inflammation -- characterized by consistently elevated levels of C-reactive protein (CRP) -- have more severe disease and worse outcomes, a retrospective study confirmed.

Steroids Use in Lupus Linked to Damage Accural

A report from Lancet Rheumatology shows that glucocorticoid use contributes to damage accrual in systemic lupus erythematosus (SLE) independent of disease activity.

The authors undertook this study to evaluate the effects of steroid use in SLE, as it often confounds analyses of activity and damage.

Rheumatic Immune-Related Adverse Events: Not Just Another IrAE

Rheumatic immune-related adverse events can start at almost any time after the commencement after immune checkpoint inhibitor immunotherapy for cancer, and are liable to persist long after the immunotherapy has ceased, according to data presented at ACR 2019 in Atlanta, Georgia.

Part 1:  The “P” in Prednisone stands for Poison...and Other Pearls

Everyone has life hacks.  Years of experience and doing the same things repetitively allow us to figure out little tricks to make life easier. A rat in a maze, finding itself at a dead end, will back up and search for a clearing. If this rat encounters its neighbor, it will transmit that information so the second rat won’t make the same mistake.

Protective Effects of ASA and Vasodilators in Systemic Sclerosis

A large cohort study suggests that the use of vasodilators and aspirin (ASA) in systemic sclerosis (SSc) may yield favorable  cardiovascular outcomes.