Wednesday, 08 Apr 2020

You are here

Bariatric Weight Loss Fails to Alter RA Risk

Obesity has been shown to be a risk factor for the onset of rheumatoid arthritis (RA) and also shown to affect outcomes by impairing responses to many DMARD therapies. A Swiss study of RA patients undergoing bariatric surgery failed to show that bariatric surgery and weight loss had any effect on the incidence of RA. 

The study examined patients in the Swedish Obese Subjects (SOS) study, which included 2002 obese patients who underwent bariatric surgery and 2034 matched controls.  While none had RA at baseline, there were 92 incident cases of RA.

Bariatric surgery did not alter the cohort risk of incident RA by 2 different analyses (Intent to treat: HR 0.92; 95% CI 0.59, 1.46, P = 0.74; per-protocol HR 0.86; 95% CI 0.54, 1.38, P = 0.53).  The bariatric surgery group lost considerable weight that was sustained (−17% BMI at 10 years) compared to +1.7% BMI for controls.

Similarly weight changes at the 2 year follow-up failed to predict the development of RA.

Risk factors for future RA included higher CRP levels and smoking.

The author has no conflicts of interest to disclose related to this subject

Add new comment

More Like This

Need for Disruptive Innovation in Rheumatology

A full-read, novel Viewpoint article published in the Annals of Rheumatic Disease (Huizinga TWJ, et al) spotlights a recent international meeting of big thinkers, scientific collaborators and industry dedicated to innovation in rheumatology.

Airway Inflammation Drives Rheumatoid Risk

A cohort analysis of the Nurses' Health Study suggests that asthma and COPD are associated with increased risk for incident rheumatoid arthritis (RA), independent of smoking- thus airway inflammation may be an important factor in the evolution of pre-cllnical RA.

Folate Levels Protect from CV Mortality in RA

In a study of rheumatoid arthritis (RA) patients, JAMA reports that serum folate level of greater than 4.3 ng/mL was associated with lower CV mortality risk.

A cohort study from the third National Health and Nutrition Examination Survey (1988-1994) and 2011 compared assess the risk of CV mortality in 683 RA patients based on their serum folate levels.

Bariatric Surgery Improves Rheumatoid Activity

Obesity is a risk factor for the onset of rheumatoid arthritis (RA) and may also an impediment to optimal DMARD and biologic responses.  A new study has shown that after 1 year, obese RA patients undergoing bariatric surgery with weight loss had significantly lower disease activity.

Seronegativity on the Rise in RA

Although the overall incidence rates of rheumatoid arthritis (RA) have remained stable over recent decades, there has been a significant increase in seronegative cases, a retrospective study showed.