Friday, 20 Apr 2018

You are here

Cardiac Disturbances Increased in Spondyloarthritis

A prospective nationwide study from Sweden analyzed patients with AS (n=6448), PsA (n=16 063),  undifferentiated spondyloarthritis (uSpA; n=5190) and a general population controls (GP; n=2 66 435) between 2001–2009 and found a higher risk of aortic regurgitation and pacemaker use in SpA and higher risk of AV block, especially in men with AS or uSpA.

Atrial fibrillation (AF) wsa most common cardiac abnormality (5.5–7.4 events per 1000 person-years), followed by pacemaker implantation (PM) (1.0–2.0 events per 1000 person-years).

AS patients had significantly  increased hazard rations (HR) for AV block (HR 2.3), AF (1.2), PM (2.1) and aortic regurgitation (1.9). Higher  rates of all of these were seen in uSpA (HRs 2.9, 1.3, 1.9 and 2.0, respectively) and PsA (HRs 1.5, 1.5, 1.6 and 1.8, respectively) compared to controls.

The highest HRs were seen for AV block in male uSpA (HR 4.2) and AS (HR 2.5) compared with GP.

Pacemakers were higher in AS (HR 1.5) and AV blodk was also higher in uSpA (HR 1.5) when compared to PsA patients.

Conduction and valvular dysfunction is more common amongst SpA patients and should be screened for, especially in men.

Disclosures: 
The author has no conflicts of interest to disclose related to this subject

Add new comment

More Like This

Apremilast in DMARD-Naive Psoriatic Arthritis

Apremilast (Otezla) monotherapy was effective for psoriatic arthritis among patients who had not previously received disease-modifying anti-rheumatic drugs (DMARDs) or biologics, a phase III clinical trial funded by the drug's manufacturer found. 

Bone Marrow Edema Found in SI Joint of Athletes

New research shows that young elite athletes will not commonly manifest bone marrow edema in the SI joint following activity.

A study in Arthritis & Rheumatology  assessed for MRI findings commonly seen in patients with axial spondyloarthropathy (axial Spa). (Citation source: https://buff.ly/2DrlCgB)

Recurrent Uveitis Increases the Risk of Ankylosing Spondylitis

Arthritis Research and Therapy reports on the epidemiologic association between recurrent anterior uveitis and ankylosing spondylitis (AS) noting that as the number of uveitis episodes increases, so does the incidence of AS.

Opioid Use in Ankylosing Spondylitis

A prospective study has shown that ankylosing spondylitis (AS) patients often require narcotic analgesics to manage pain unresponsive to antiinflammatory therapies.

AS patients (n=706) were serially assessed (every 6 months) and outcome measures were collected, including disease activity and functional measures (BASDAI, BASFI), along with radiographic outcomes.  Investigators specifically looked at opioid usage.

Cimzia Limits Xray Progression in Axial Spondyloarthritis

The RAPID-axSpA study of ankylosing spondylitis (AS) and non-radiographic axial spondyloarthritis (nr-axSpA) patients showed that certolizumab pegol (CZP) treatment yielded rapid clinical improvement with limited radiographic progression and MRI inflammation at the sacroiliiac (SI) joint over 4 years.