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Does Cirrhosis Increase the Risk of Autoimmune Disorders?

A Danish nationwide healthcare registry was used to identify newly diagnosed alcoholic cirrhosis patients between 1977 and 2010. A matched cohort analysis compared each patient with five random individuals from the population. Of the 24,679 patients diagnosed with alcoholic cirrhosis, 532 developed an autoimmune disease, with an adjusted incidence rate ratio 1.36 (95%;CI, 1.24-1.50). The strongest associations were seen with Addison's disease (aIRR = 2.47), inflammatory bowel disease (aIRR = 1.56), celiac disease (aIRR = 5.12), pernicious anemia (aIRR = 2.35), and psoriasis (aIRR = 4.06). There was no increase noted for rheumatoid arthritis (aIRR = 0.89) and the rate was lower for polymyalgia rheumatica (aIRR = 0.47; 95% CI, 0.33-0.67).

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