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Fatigue is Driven by Inflammation, Pain, and Chronicity in Psoriatic Arthritis

Correlates with fatigue were assessed in psoriatic arthritis (PsA) patients in the DANBIO registry and found to be associated with  clinical inflammatory factors, disease duration, and chronic pain.

A toital of 2062 PsA patients in the Danish nationwide registry DANBIO were studied by cross-sectional survey from December 2013 to June 2014.

Ultimately there were into three co-variables explaining 63% of fatigue in PsA patients:

  1. 31% of fatigue was linked to inflammatory factors (swollen and tender joints, MD global assessment, elevated CRP)
  2. 17% of fatigue was related to increasing age and long disease duration
  3. 15% was associated with chronic pain variables - i.e., high PDQ score, tender joint count, etc.

Fatigue in PsA patients may be driven by clinical inflammatory factors, disease duration, and chronic pain in the absence of inflammation.

(Editors note: the primary drivers of fatigue in the vast majority of patients with musculoskeletal symptoms are a) poor sleep; b) depression; and c) inflammation)

Disclosures: 
The author has no conflicts of interest to disclose related to this subject

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