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A French retrospective study of 318 Takayasu's arteritis (TA) patients shows that 50% of patients will relapse and experience a vascular complication ≤10 years from diagnosis.
A multicenter study examined 318 TA patients meeting both ACR and and Ishikawa criteria to assess event-free survival, relapse-free survival, vascular complications and risk factors for vascular complications. At diagnosis, TA primarily affects younger (mean age 36 [25–47] years) women (86.8%).
With 6.1 years of follow-up, relapses were observed in 43%, vascular complications in 38%, and death in 5%.
Progressive disease course (P=0.018) and carotidynia (P=0.036) were independently associated with event-free survival.
|5 Year||10 Year||Associations|
|Event-Free Survival||48.2%||36.4%||Progressive disease course (P=0.018) and carotidynia (P=0.036)|
|Relapse-Free Survival||58.6%||47.7%||Male sex (P=0.048), elevated C-reactive protein (P=0.013), and carotidynia (P=0.003)|
|Complication-Free Survival||69.9%||53.7%||Progressive disease course (P=0.017), thoracic aorta involvement (P=0.009), and retinopathy (P=0.002)|
Conclusions: This nationwide study shows that 50% of patients with TA will relapse and experience a vascular complication ≤10 years from diagnosis.