Half of Takayasu's Arteritis Relapse Save
A French retrospective study of 318 Takayasu's arteritis (TA) patients shows that 50% of patients will relapse and experience a vascular complication ≤10 years from diagnosis.
A multicenter study examined 318 TA patients meeting both ACR and and Ishikawa criteria to assess event-free survival, relapse-free survival, vascular complications and risk factors for vascular complications. At diagnosis, TA primarily affects younger (mean age 36 [25–47] years) women (86.8%).
With 6.1 years of follow-up, relapses were observed in 43%, vascular complications in 38%, and death in 5%.
Progressive disease course (P=0.018) and carotidynia (P=0.036) were independently associated with event-free survival.
Outomes observed:
| 5 Year | 10 Year | Associations | |
| Event-Free Survival | 48.2% | 36.4% | Progressive disease course (P=0.018) and carotidynia (P=0.036) |
| Relapse-Free Survival | 58.6% | 47.7% | Male sex (P=0.048), elevated C-reactive protein (P=0.013), and carotidynia (P=0.003) |
| Complication-Free Survival | 69.9% | 53.7% | Progressive disease course (P=0.017), thoracic aorta involvement (P=0.009), and retinopathy (P=0.002) |
Conclusions: This nationwide study shows that 50% of patients with TA will relapse and experience a vascular complication ≤10 years from diagnosis.
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