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Hand and knee osteoarthritis are considered to be clinically and pathogenically different and distinct, but a new study suggests that Heberden's nodes (HNs) can predict MRI‐based knee osteoarthritis (OA) progression.
An NIH study of 575 subjects included clinical examination with evaluation of HNs at baseline and knee MRI at baseline and 24‐month.
Patients with HN (395) were found to have more periarticular bone area expansion in knee joint (adjusted odds ratio 1.39 (1.06 ‐ 1.83)) especially in medial femur (aOR 1.49 (1.05 ‐ 2.13)) and lateral femur (aOR 2.51 (1.58 ‐ 3.97)), femoral notch (aOR 1.37 (1.02 ‐ 1.84)) and lateral trochlea (aOR 1.44 (1.08 ‐ 1.9)) over 24‐months.
Yet less osteophyte worsening was seen HN+ subjects.
HN maybe associated with an increased OA progression of the knee. The role of therapeutics in these findings was not evaluated.