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Compliance and adherence was shown to be quite poor in fibromyalgia (FM) patients, with high rates of drug discontinuation and greater than 60% demonstrated low adherence.
Using claims data from a large, Israeli, health maintenance organization 3922 FM were assessed from 2008 through 2011; specifically looking at the following agents over a 12 month period: pregabalin, antidepressants [selective serotonin reuptake inhibitor (SSRI), serotonin/norepinephrine reuptake inhibitor (SNRI)], and tricyclic antidepressants (TCA).
The proportion of days covered (PDC) was used as a measure of drug adherence. A PDC < 20% was considered low adherence and PDC ≥ 80% was considered high adherence.
Of the 56.1% issued a qualifying prescription, 45.0% were dispensed at least 1 medication in the year following diagnosis, and only 28.8% had prescriptions filled twice within the first year from diagnosis.
The 1-year drug discontinuation was highest for TCA (91.0%) and lowest for SSRI/SNRI antidepressants (73.7%).
Over half of the patients (60.5%) had fewer than 20% of the days covered by any medication during the year and only 9.3% were very adherent (PDC ≥ 80%).
FM management may be confounded and complicated by high drug discontinuations and low adherence.