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IBD Associated with Increased risk of Autoimmune and Inflammatory Diseases

A registry based study has shown higher rates of immune mediated diseases (IMD) in patients with inflammatory bowel disease (IBD).

Researchers examined 47325 IBD patients from the Danish National Patient Registry and compared them to controls from a civilian registry and used ICD 10 codes to identify the diagnoses observed.

Overall they found 20 different IMDs were found to be significantly more frequent in the IBD group - 16 associated with ulcerative colitis (UC) and 12 with Crohns disease (CD).  Having IBD showed significantly increased ORs of having:

  • primary sclerosing cholangitis (PSC),
  • celiac disease,
  • type 1 diabetes (T1D),
  • sarcoidosis,
  • asthma,
  • iridocyclitis,
  • psoriasis,
  • pyoderma gangrenosum,
  • rheumatoid arthritis,
  • ankylosing spondylitis.

Disorders seen predominantly with UC  were autoimmune hepatitis, primary biliary cholangitis, Grave's disease, polymyalgia rheumatica, temporal arteritis , and atrophic gastritis.

Restricted to CD were psoriatic arthritis and episcleritis.

Restricted to women with UC were atrophic gastritis, rheumatoid arthritis, temporal arteritis, and polymyalgia rheumatica.

Restricted to women with CD were episcleritis, rheumatoid arthritis, and psoriatic arthritis.

The only disease restricted to men was sarcoidosis.

Considerable overlap exists between these IMDs and IBD.

Disclosures: 
The author has no conflicts of interest to disclose related to this subject

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