Friday, 20 Oct 2017

You are here

IBD Associated with Increased risk of Autoimmune and Inflammatory Diseases

A registry based study has shown higher rates of immune mediated diseases (IMD) in patients with inflammatory bowel disease (IBD).

Researchers examined 47325 IBD patients from the Danish National Patient Registry and compared them to controls from a civilian registry and used ICD 10 codes to identify the diagnoses observed.

Overall they found 20 different IMDs were found to be significantly more frequent in the IBD group - 16 associated with ulcerative colitis (UC) and 12 with Crohns disease (CD).  Having IBD showed significantly increased ORs of having:

  • primary sclerosing cholangitis (PSC),
  • celiac disease,
  • type 1 diabetes (T1D),
  • sarcoidosis,
  • asthma,
  • iridocyclitis,
  • psoriasis,
  • pyoderma gangrenosum,
  • rheumatoid arthritis,
  • ankylosing spondylitis.

Disorders seen predominantly with UC  were autoimmune hepatitis, primary biliary cholangitis, Grave's disease, polymyalgia rheumatica, temporal arteritis , and atrophic gastritis.

Restricted to CD were psoriatic arthritis and episcleritis.

Restricted to women with UC were atrophic gastritis, rheumatoid arthritis, temporal arteritis, and polymyalgia rheumatica.

Restricted to women with CD were episcleritis, rheumatoid arthritis, and psoriatic arthritis.

The only disease restricted to men was sarcoidosis.

Considerable overlap exists between these IMDs and IBD.

Disclosures: 
The author has no conflicts of interest to disclose related to this subject

Add new comment

More Like This

BSR Guidelines on Lupus Management

In the UK, NICE has accredited the British Society of Rheumatology (BSR) to develop a guidance document on the management of systemic lupus erythematosus in adults.  The last published guidelines for lupus were published in 2008 by EULAR and in 2012 by the ACR.

Primary Sjögren's Syndrome Guideline from the British Society for Rheumatology

The British Society of Rheumatology (BSR) has been accredited by NICE to develop a guidance document for the management of primary Sjögren's Syndrome intended for rheumatologists, general physicians, general practitioners, specialist nurses and other specialists (e.g. ophthalmologists, dental practitioners and ENT specialists),

Isolated SS-B Not Associated with Connective Tissue Disease

A one-year prospective study of 624 patients undergoing autoantibody testing for anti-SS-A and/or anti-SS-B autoantibodies finds that isolated anti-SS-B autoantibodies was not associated with features or the diagnosis of any specific connective tissue diseases (CTD).

Half of Takayasu's Arteritis Relapse

A French retrospective study of 318 Takayasu's arteritis (TA) patients shows that 50% of patients will relapse and experience a vascular complication ≤10 years from diagnosis. 

Past Infection, Lung Disease Raise Risk for Myopathy

Infections and noninfectious pulmonary disease were associated with an increased risk for idiopathic inflammatory myopathies (IIM), a Swedish study found.