Friday, 13 Dec 2019

You are here

IV Cyclophosphamide Equal to Mycophenolate in Lupus Nephritis

A comparison of mycophenolate mofetil (MMF) and low-dose cyclophosphamide IV (CYC) in the treatment of lupus nephritis (LN) was examined in 173 patients with class III, IV, or V LN.

In this trial, all patients received three methylprednisolone injections followed by oral corticosteroids, and then maintained on azathioprine and low-dose corticosteroid for a total of 24 weeks. The primary endpoint of treatment response at 24 weeks was assessed using the Systemic Lupus Erythematosus Disease Activity Index and adverse events.

100 patients were randomized to receive either CYC or MMF. The complete remission rate was 50% in CYC and 54% in MMF group at week 24. Gastrointestinal symptoms were significantly more frequent in patients receiving MMF (52 vs. 4%). However, other adverse events were similar.

Thus, low-dose intravenous CYC is comparable in efficacy to oral MMF in the induction treatment of less severe LN.

The author has no conflicts of interest to disclose related to this subject

Add new comment

More Like This

CRP in SSc: Identifying a Severe Phenotype

Patients with systemic sclerosis (SSc) who have persistent inflammation -- characterized by consistently elevated levels of C-reactive protein (CRP) -- have more severe disease and worse outcomes, a retrospective study confirmed.

Steroids Use in Lupus Linked to Damage Accural

A report from Lancet Rheumatology shows that glucocorticoid use contributes to damage accrual in systemic lupus erythematosus (SLE) independent of disease activity.

The authors undertook this study to evaluate the effects of steroid use in SLE, as it often confounds analyses of activity and damage.

Rheumatic Immune-Related Adverse Events: Not Just Another IrAE

Rheumatic immune-related adverse events can start at almost any time after the commencement after immune checkpoint inhibitor immunotherapy for cancer, and are liable to persist long after the immunotherapy has ceased, according to data presented at ACR 2019 in Atlanta, Georgia.

Part 1:  The “P” in Prednisone stands for Poison...and Other Pearls

Everyone has life hacks.  Years of experience and doing the same things repetitively allow us to figure out little tricks to make life easier. A rat in a maze, finding itself at a dead end, will back up and search for a clearing. If this rat encounters its neighbor, it will transmit that information so the second rat won’t make the same mistake.

Protective Effects of ASA and Vasodilators in Systemic Sclerosis

A large cohort study suggests that the use of vasodilators and aspirin (ASA) in systemic sclerosis (SSc) may yield favorable  cardiovascular outcomes.