Thursday, 21 Mar 2019

You are here

Limited Impact of Vitamin D Supplementation

A systematic review of 81 studies on vitamin D concludes that vitamin D supplementation does not prevent fractures or falls, or have clinically meaningful effects on bone mineral density.

Metanalyses specifically looked at studies addressing total or hip fractures, falls, or bone mineral density measured at the lumbar spine, total hip, femoral neck, total body, or forearm.

A total of 81 randomised controlled trials (n=53 537 participants) reported fracture (n=42), falls (n=37), or bone mineral density (n=41).

In pooled analyses, vitamin D had no effect on total fracture (36 trials; RR 1·00, 95% CI 0·93–1·07), hip fracture (20 trials; RR  1·11, 0·97–1·26), or falls (37 trials; RR 0·97, 0·93–1·02).  Results were similar with low or high dose vitamin D supplements. 

These conclusions should be reflected in clinical guidelines.

Disclosures: 
The author has no conflicts of interest to disclose related to this subject

Add new comment

More Like This

CRA Position Statement on Medical Cannabis Use

Courtesy of the Canadian Rheumatology Association (CRA) website, here are consensus guidelines on medical cannabis use.

Rheumatology patients experience prevalent pain that is only modestly controlled with current treatment strategies.

Senate Drills Drug Makers Over Price

Reuters reported that today, the US Senate Finance Committee met to question the executives from seven US pharmaceutical companies on the rising price drugs in America. 

Canadian Vaccination Guidelines for the Immunosuppressed

A multidisciplinary Canadian task force has developed guidelines for vaccination in patients receiving immunosuppressive therapies, based on the evidence that immunosuppressive use in immune-mediated disease may be  associated with an elevated risk of infections. 

No Difference in Oral or IV Antibiotics for Bone & Joint Infections

Research from the NEJM shows that oral antibiotic therapy was noninferior to intravenous antibiotic therapy when used during the first six weeks for complex orthopedic infections.

There is considerable discussion whether complex bone and joint infections must be managed with prolonged intravenous antibiotics or if oral antibiotic therapy may suffice. 

2019: the Year of Price Hikes

In 2019 there have been numerous reports of higher drug pricing for many drugs.  Yesterday it was reported that the price of insulin drugs have more than doubled from 2012 to 2016.

Reuters reports that in the United States, the pricing on more than 250 prescription drugs have gone up.